Rapid Nano-Flow Cytometry for Virus Detection (No. 0192)

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A novel nano-flow cytometry approach that can detect very small bio-particles such as viruses.

The global flow cytometry market size is projected to grow at a CAGR of 8.3%. Market growth is largely driven by factors such as technological advancements in flow cytometers, the increasing adoption of flow cytometry techniques in research activities and clinical trials, and the growing focus on immunology and immuno-oncology research. Flow cytometry is a general method for rapidly analyzing large numbers of cells individually using light-scattering, fluorescence, and absorbance measurements. However, the size measurements are highly influenced by the refraction index, and thus practically limited to larger sized particles. For very small particles, the scattering light intensity drops quickly and thus it becomes rather difficult to determine the size of virus and other small important biological particles. Here we present a promising flow cytometry approach proposed by a group of researchers led by Prof. Tsumoru Shintake. The novel approach is based on using an interference fringe to rapidly detect nano sized biological particles such as viruses.


Lead Researcher:
Tsumoru Shintake

Faculty of Quantum Wave Microscopy Unit


  • Biological analytics
  • Virus detection



  • Nano particle detection range
  • Absolute size measurement
  • Rapid analysis


This novel flow cytometry technology is based on a system where two laser beams overlap, creating interference fringe (like Young's experiment), whose pitch becomes a smaller wavelength. As a result of the interference fringe, this novel approach can detect scattering light from particles and measure modulation depth (Fourier component of particle shape), which gives particle size for smaller virus and other biological particles.


Media Coverage and Presentations

 JST Technology Showcase Presentation (JP Only)

 JST Technology Showcase Presentation Slides (JP Only)



  Graham Garner
Technology Licensing Section