4-substituted pyridine-2,6-dicarboxylic acid derivatives (No. 0071)

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4-substituted pyridine-2,6-dicarboxylic acid derivatives having potential therapeutic or preventative medicine (prophylaxis) applications.

The global therapeutic drug market size is currently about USD 285 billion and is projected to reach USD 420 billion at a CAGR of %. 4-substituted pyridine-2,6-dicarboxilic acids and their derivatives are important as building blocks in the synthesis of bioactive and biofunctional molecules, probes for visualization of cells and molecules of interest, solid-support reagents, and other functional molecules. However, previously reported methods for the synthesis of substituted pyridine-2,6-dicarboxylic acid derivatives often require long routes and severe conditions. Here, we present a promising synthesis method developed by a group of researchers led by Prof. Fujie Tanaka. The developed technology overcomes the above problems and provides a short and simple one pot method unlocking new derivatives.


Lead Researcher:
Fujie Tanaka

Faculty of Chemistry and Chemical Bioengineering Unit


Generation of bioactive compounds for multiple purposes:

  • Therapeutic drugs
  • Preventative medicine drugs
  • Probes



  • One pot synthesis
  • Mild synthesis conditions
  • Atom-economical method

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Technology's Essence

Essentially, Prof. Tanaka has developed a novel chemically and biologically important 4-substituted pyridine-2,6-dicarboxylic acid derivatives synthesis method. 4-Substituted-pyridine-2,6-dicarboxylic acid derivatives were synthesized in one pot under mild conditions via the formation of dihydropyran derivatives from pyruvates and aldehydes catalyzed by pyrrolidine-acetic acid, followed by the reaction with ammonium acetate.


Media Coverage and Presentations



  Graham Garner
Technology Licensing Section