Novel Synthesis of 4-Substituted Pyridine-2,6-Dicarboxylic Acid Derivatives (No. 0071)
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4-Substituted pyridine-2,6-dicarboxilic acids and their derivatives are important building blocks in the synthesis of bioactive molecules, chemical probes for biological research, solid-supported reagents and other functional molecules. However, known methods for the synthesis of 4-substituted pyridine-2,6-dicarboxylic acids derivatives often require long synthetic routes and harsh conditions. A team of OIST researchers led by Prof. Fujie Tanaka has developed a new synthetic protocol that overcomes the above problems and provides a simple one-pot method to unlock new derivatives.
- Therapeutic and preventative medicine
- Drug development
- Chemical probes for biological research
- Mild conditions
- One-pot reaction
- High atom economy
This is a novel method to synthesize chemically and biologically important 4-substituted pyridine-2,6-dicarboxylic acid derivatives, whereby pyruvates and aldehydes are reacted with a pyrrolidine-acetic acid catalyst to form dihydropyran derivatives, which are further reacted with ammonium acetate in one pot under mild conditions to yield the desired products.
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