Oligosaccharide C-glycoside Derivatives For Drug Discovery (No. 0139)

 
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Summary

A novel method to synthesize C-glycoside derivatives.

The global drug discovery market size is anticipated to reach USD 110 billion by 2025, expanding at a CAGR of 9.6% over the forecast period. Carbohydrates play important roles in biological systems and thus the synthesis of carbohydrate derivatives is of interest in drug discovery. Such derivatives can be produced by C-glycosidation of carbohydrates under various reactions. However, the most direct C-glycosidation reactions of unprotected carbohydrates are technically difficult because of the presence of certain chemical groups and structural forms in the carbohydrates. Here we present a promising C-glycoside synthesis method developed by a group of researchers led by Prof. Fujie Tanaka. The method allows for direct synthesis of c-glycoside derivatives at low temperature.

 

Lead Researcher:
Fujie Tanaka

Faculty of Chemistry and Chemical Bioengineering Unit

Applications

  • Therapeutic Pharmaceuticals
  • Diagnostic Reagents and Probes
  • Drug Discovery

 

Advantages

  • New C-Glycoside Derivatives
  • Direct Synthesis at low temperature
  • High Stereoselectivity

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Technology's Essence

The technology is based on a new synthetic method for direct C-glycosidation reactions of unprotected di- and trisaccharides with ketones at low temperature. In the method, a substrate carbohydrate is mixed with a substrate ketone in the presence of a reaction catalyst acid. The direct reaction products of this reaction are functionalized di- and trisaccharide C-glycoside derivatives.

 

Media Coverage and Presentations

 

CONTACT FOR MORE INFORMATION

  Graham Garner
Technology Licensing Section

  tls@oist.jp
  +81(0)98-966-8937