Oligosaccharide C-glycoside Derivatives For Drug Discovery (No. 0139)

Summary

A novel method to synthesize C-glycoside derivatives.

The global drug discovery market size is anticipated to reach USD 110 billion by 2025, expanding at a CAGR of 9.6% over the forecast period. Carbohydrates play important roles in biological systems and thus the synthesis of carbohydrate derivatives is of interest in drug discovery. Such derivatives can be produced by C-glycosidation of carbohydrates under various reactions. However, the most direct C-glycosidation reactions of unprotected carbohydrates are technically difficult because of the presence of certain chemical groups and structural forms in the carbohydrates. Here we present a promising C-glycoside synthesis method developed by a group of researchers led by Prof. Fujie Tanaka. The method allows for direct synthesis of c-glycoside derivatives at low temperature.

Applications

• Therapeutic Pharmaceuticals
• Diagnostic Reagents and Probes
• Drug Discovery

Advantages

• New C-Glycoside Derivatives
• Direct Synthesis at low temperature
• High Stereoselectivity