A Recipe for Scientific Synergy Series 1 by Dr. Svante Pääbo and Dr. Hisashi Arase


2021年11月10日 (水) 16:00 17:00





OIST and Osaka University have been building a healthy relationship.

Osaka University, values its relationship with the free and unfettered civic society of Osaka and nurturing the spirit of a "university in society, for society."  OIST will learn from Osaka about symbiotic relationships with society and the surrounding community.  OIST, in turn, would like to share our world-leading research with Osaka University.  Through these exchanges, we hope to establish synergistic relationships to achieve scientific breakthroughs that to contribute to society.

Speaker, Title and Abstract:

Dr. Svante Pääbo, OIST

Title:"Archaic Genomics"

Our laboratory works on methods to retrieve DNA from ancient bones and other tissue remains. We take a particular interest in Denisovans and Neandertals, extinct human forms. We have shown that gene flow occurred among modern human ancestors and these archaic hominins. As a consequence, about 2.0% of the genomes of people living outside Africa come from Neandertals while about 4.0% of the genomes of people living in Oceania come from Denisovans. These genetic contributions have numerous physiological and medical consequences today. I will discuss recent insights into archaic genetic variants affect pain sensitivity, the risk for miscarriages, and the risk to develop severe disease when infected by SARS-CoV-2.



Dr. Hisashi Arase, Osaka University

Title:"Neutralizing and enhancing and antibodies against SARS-CoV-2 virus"

Neutralizing antibodies against the SARS-CoV-2 spike protein play an important role in preventing SARS-CoV-2 infection. However, some antibodies were found to change the conformation of the spike protein, and thus enhance the SARS-CoV-2 infectivity. Therefore, it is important to consider the balance of the enhancing antibodies and neutralizing antibodies in SARS-CoV-2 infection. In this talk, I will discuss on the function of neutralizing and infectivity-enhancing antibodies on SARS-CoV-2 infection as well as effect on the mutations on the spike protein observed in SARS-CoV-2 variants.




Dr. Matthias Wolf, OIST

Professor, Molecular Cryo-Electron Microscopy Unit



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