Members

Faculty Member

Dr. Paola Laurino

Unit members

Dr. Saacnicteh Toledo Patino, Postdoctoral Scholar

Email: saacnicteh.toledo[at]oist.jp

I was born on May 28th, 1984 in Morelia, Mexico where I studied Chemical Pharmacobiology at UMSNH University (2002-2006). I studied Biochemistry at Eberhard-Karls University of Tuebingen (2008-2013), where I obtained my Masters degree in Protein Design (2013). I obtained my PhD in Biochemistry at the Max Planck Institute for Developmental Biology in the same city (2014-2019). During my doctoral studies I joined the University of Bayreuth as a scientific employee (2016-2019). Since December 2019 I work in Prof. Laurino's unit for Protein Design and Evolution where I carry out projects on the emergence of the Rossmann fold and its ligand diversification.

Dr. Benjamin Clifton, JSPS Postdoctoral Fellow

Email: benjamin.clifton[at]oist.jp

I was born in Sydney, Australia and completed an undergraduate degree in chemistry (PhB (Sci) Hons) and PhD degree in protein biochemistry (2013-2016) at the Australian National University in Canberra. Protein evolution has been a longstanding interest for me, in particular, understanding how complex and functionally diverse proteins evolve through a simple process of mutation and selection, and how we can use this knowledge practically for protein engineering purposes.

During my PhD research in Prof. Colin Jackson's group, I studied the evolution of new protein functions in the solute-binding protein superfamily using ancestral protein reconstruction, a technique that allows extinct proteins to be recreated so that their evolutionary history can be studied in the lab. I then worked in a research role at Affinity Bio (Melbourne, Australia, 2017-2019), where I contributed to the development of antibodies against challenging targets for use in cancer immunotherapy. I joined the Protein Engineering and Evolution Unit at OIST in January 2020 to study how cellular tRNA modifications affect the outcome of protein evolution by controlling the error rate of protein synthesis. I'm also interested in developing new methods for functional annotation of solute-binding proteins for use in biosensor applications.

Dr. Prashant Jain, Postdoctoral Scholar

Email: prashant.jain[at]oist.jp

I am Prashant, born and brought up in the capital of India, Delhi. After completing my bachelor's in 2014 from my hometown, I moved to Pune for higher studies. I joined the Indian Institute of Science Education and Research (IISER), Pune, under an integrated Ph.D. program. After completing my master's (2014-2016), I obtained my Ph.D. in organic chemistry under Dr. Raghavendra Kikkeri in 2021. I joined OIST as a postdoctoral fellow in May 2021 in Prof Laurino's unit. Here, I am looking forward to playing with RNAs to unravel fundamental questions surrounding the RNA universe.

Dr. Yusran Abdillah Muthahari, Postdoctoral Scholar

Email: yusran.muthahari[at]oist.jp

Hi all! My name is Yusran; was born in Garut, Indonesia. I completed my undergraduate and master's degree in Chemistry at Institut Teknologi Bandung, Indonesia (2010-2015). I acquired my double Ph.D. degree from the University of Groningen (the Netherlands) and KU Leuven (Belgium) in 2021. I then continued the research of my thesis for one year at IMBB-FORTH, Greece in Prof. Gkouridis Lab before joining the Protein Engineering and Evolution Unit of Prof. Laurino at OIST in July 2022.

I have a massive interest in protein evolution, specifically in how protein could acquire/delete modular structural elements to evolve distinct functions. Such may lead us on understanding why nature performs addition/deletion besides mutation during evolution. For that, we need to uncover the relationship between the structure, dynamics, energetics, and functions of the protein. In my previous study, I tested such a concept using solute binding proteins (SBPs). With Prof. Laurino, I would like to explore if such is also applicable to enzymes! I will mainly work on modular enzymes and see how similar cores can adapt to various modular elements during evolution. Besides, I am also interested in how life could emerge, and adapt from so simple a beginning. Personally, I truly hope that understanding the origin of life would help me to deepen my understanding of the meaning of life.

Dr. Gen-ichiro Uechi, Technician

Email: Gen-ichiro.Uechi[at]oist.jp

I'm Uechi. I joined in Apr. 2019. I was born in Okinawa and got a Ph.D. at the University of the Ryukyus.  I want to spread the beauty of Okinawa and want to be a bridge with younger generation

Mr. Stefano Pascarelli, PhD Student

Email: stefano.pascarelli1[at]oist.jp

I have always been fascinated by is evolution, and how it is able to explain how complex life developed from a simple mixture of atoms. It takes place in so many scales, from proteins to populations. Exploring evolution means understanding the forces involved in developing complexity, and who knows, maybe even being able to reproduce them. I want evolution to be a prominent topic during my time at OIST. Specifically, protein evolution and the different levels of complexity a protein can achieve in evolve.

OIST is a place that really represents my ideologies in science. It is a peaceful place where collaborate with each other towards a common goal is possible. It is the best environment for scientists to make a difference in their field.

We must never forget that science is a community. On one side, it allows the knowledge to be accessible and shared, like a magic wallet that makes everyone that possess it equally richer by anyone’s contribution. On the other side, a community of humans is not new to mistakes, but in this case, the history of the past can help us correct them. I believe in a borderless scientific community, if not the whole Earth’s community, without discriminations. The instinct of segregating in small, aggressive groups served us well during evolution. Now, it is a dangerous remain of the past, that might annihilate Humanity. I am considerate towards tolerating the differences, learning from another culture, respecting other ideals up to the limit of rationality. The only way to do so is to dive deep in the melting pot. To be an experience to the others as much as they are to you. Static environments more hardly lead to progress.

Mr. Alessandro Bevilacqua, PhD Student

Email: alessandro.bevilacqua[at]oist.jp

I was born in Milan (Italy) where I obtained a master's degree in Plant Biotechnology at University of Milan. During my master's thesis I worked on protein expression and purification; since that experience, I have been interested in proteins' world.
I started my PhD here at OIST in January 2020 and I am really enjoying my stay here in Okinawa, both for the amazing places around and for how OIST do science: by promoting inclusion, equity, know-how sharing between different fields. 
I feel I am in a community that is working together to promote a better future and, in my opinion, this is what science should be about. In fewer word: sow science to harvest future!

Mr. Yoshiki Ochiai, PhD Student

Email: yoshiki.ochiai[at]oist.jp

I was born and grew up in Osaka, Japan. I studied in molecular biology, biochemistry, and biophysics at Soka University, Tokyo. I got my master degree in Saitama university, and, at the same time, I worked in RIKEN Center for Sustainable Resource Center (CSRS) and The University of Tokyo. I joined in Protein Engineering and Evolution Unit from May 2020. Here I have engaged in designing novel enzymes for solving biological problems.

 

 

Mr. Dan Kozome, PhD Student

Email: dan.kozome2[at]oist.jp

I was born and raised in Tokyo and moved to Okinawa in 2013. I obtained a bachelor's and master's degree in Agriculture at the University of the Ryukyus, where I was engaged in thermostabilizing an enzyme and in creating chimera enzymes by protein engineering (2013-2019). After internship and Gap program research at this Unit, I finally joined the Protein Engineering and Evolution Unit as a PhD student to start research focusing on how proteins acquire the function.  I am so happy to come back here to work with wonderful members and in a fascinating environment.

 

 

Ms. Amy Gooch, PhD Student

Email: amy.gooch[at]oist.jp

I graduated from Durham University (in the UK) with a Joint Honours degree in Biology and Chemistry. My background is in organic chemistry and biochemistry, and I have a keen interest in the sophisticated chemistry carried out by enzymes. During my masters, I used the nickel-responsive regulator (NikR) as a model protein to probe the mechanisms by which proteins are loaded with their cognate metal(s). I joined the Protein Engineering and Evolution Unit so that I may investigate fascinating new topics related to proteins. Whilst carrying out my rotation in this unit, I hope to develop new skills and techniques, and learn a lot from the other members!

Ms. Lilian Magnus, PhD Student

Email: lilian.magnus[at]oist.jp

I was born in Düsseldorf, Germany but spent most of my childhood in Belgium, after which I completed my bachelors and Masters degree at Imperial College London. It was there that I studied cellular biology and developed a real passion for science. During my undergraduate studies I was also able to complete an internship in Mishima, Shizuoka which sparked my interest in potentially returning to Japan for my phd studies. 

Originally I had joined the Laurino Lab as my out of field rotation, but I quickly fell in love with my project. As someone who really loves exploring the newer areas of science, this lab allows me to use cutting edge techniques to pursue questions at the forefront of the field, while working on becoming a better scientist!

Ms. Erika Fukuhara, PhD Student

Email: erika.fukuhara[at]oist.jp

I was born in Okinawa but grew up mostly outside of Japan - in Germany and in the United States. I graduated from the University of Georgia with a bachelor's in Biology. During my undergraduate studies, I developed a growing interest in proteins, particularly protein interactions and their associated mechanisms. 

Having roots in Okinawa, starting my PhD studies at OIST has not only allowed me to pursue a graduate education but also has provided me an opportunity to reconnect with my Okinawan family. I joined the Protein Engineering and Evolution Unit from May 2022 as a rotation student. I am looking forward to gaining new skills and exploring the world of proteins during my rotation.

Ms. Adriana Hernández González, Research Intern

Email: adriana.hernandez[at]oist.jp

I was born in Mexico City, I recently graduated from the BSc. in Basic Biomedical Research at Universidad Nacional Autónoma de México (UNAM). I have had the opportunity to be in different laboratories and I found that my greatest interest is in Evolutionary and Structural Biology. I am grateful and happy to be in the Laurino Unit where I can learn more about the evolution of proteins.

 

Ms. Mika Uehara, Research Unit Administrator

Email: mika.uehara[at]oist.jp