Seminar by Prof. Aikichi Iwamoto. "Chasing a single amino acid substitution in HIV-1 circulating among Japanese population."

Dear all,

Cell Signal Unit(Yamamoto Unit) would like to invite you to a seminar by Prof. Aikichi Iwamoto.

We look forward to seeing many of you there.

Speaker: Prof. Aikichi Iwamoto

The University of Tokyo The Institute of Medical Science

Advanced Clinical Research Center Division of Infectious Diseases,

Research Hospital Division of Infectious Diseases and Applied Immunology

Title: Chasing a single amino acid substitution in HIV-1 circulating among Japanese population.

Abstract: Cytotoxic T lymphocytes (CTLs) are key players in the immune control of Human Immunodeficiency Virus 1 (HIV-1), as they recognize virally-derived peptide epitopes presented by HLA class I molecules on the infected cell surface (pHLA). The genetic hypermutability of HIV-1 can interfere with immune surveillance by CTL by introducing amino acid changes that allow the virus to “escape” immune recognition. Escape phenomena may occur at different steps during the process of antigen presentation and recognition. Mutations can result in changes in processing the viral proteins or in the way such that the processed peptides cannot bind to the HLA molecules or the pHLA cannot interact properly with TCR. HLA molecules are highly polymorphic, therefore, escape mutations put fingerprints on HIV-1 in infected individuals but also in the population that shares the same HLA. I would like to present our data initiated from the clinical observation.

Host: 

Tadashi Yamamoto, Cell Signal Unit

Cell Signal Unit (Yamamoto Unit)