Seminar by Dr. Atsushi Shimada. "Structural biology of clathrin-mediated endocytosis"

Cell Signal Unit(Yamamoto Unit) would like to invite you to a seminar by Dr. Atsushi Shimada.

We look forward to seeing many of you there.

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Date: Monday, July 7^th, 2014

Time: 16:00 – 17:00

Venue: C016, Lab1

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Speaker: Dr. Atsushi Shimada

Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University

Title: Structural biology of clathrin-mediated endocytosis

Abstract: Clathrin-mediated endocytosis (CME) is a process for eukaryotic cells to internalize extracellular molecules. CME plays a role in various physiological processes, such as receptor internalization, synaptic vesicle recycling, and somatic nutrient uptake. CME is also utilized as an entry portal by pathogenic viruses/bacteria and is implicated in cancer, thus is medically relevant. A number of soluble proteins, including clathrin, AP-2 complex, dynamin, and other recently identified endocytic proteins, such as the BAR-superfamily proteins, are involved in CME. We have been investigating the structural bases of protein-lipid and protein-protein interactions involved in CME by X-ray crystallography and a range of biochemical and cell biological techniques (Shimada et al., Cell, 2007). In this seminar, the functions of endocytic proteins, FCHo1/FCHo2/SGIP1 and CIP4/FBP17, which are involved in the initial clathrin-assembly and subsequent invagination steps of CME, respectively, will be discussed based on their structures.

Host: 

Tadashi Yamamoto, Cell Signal Unit