FY2015 Annual Report

Cell Signal Unit

Professor Tadashi Yamamoto



1. Staff

  • Dr.Toru Suzuki, Group leader
  • Dr.Olga Elisseeva, Group leader
  • Dr.Naosuke Hoshina, Postdoctoral Scholar
  • Dr.Yo-taro Shirai, Postdoctoral Scholar
  • Dr.Taku Kureha, Postdoctoral Scholar
  • Dr.Akinori Takahashi,  Postdoctoral Scholar
  • Dr.Kristopher Paraiso Montrose, Postdoctoral Scholar
  • Ms.Miyuki Hoshina, Technical Staff
  • Ms.Chisato Kikuguchi, Technical Staff
  • Ms.Miho Tokumasu, Technical Staff
  • Ms.Aja Sanzone, Technical Staff
  • Ms.Tiziana Paganini, Technical Staff
  • Ms.Sandrine Anne Laure  Burriel-Ha, Graduate Student
  • Mr.Haytham Mohamed Aly Mohamed, Graduate Student
  • Mr.Shohei Takaoka, Graduate Student
  • Mr.Hemanta Sarmah, Graduate Student
  • Ms.Dina Mostafa, Graduate Student
  • Ms.Kaori Yamashiro, Research Administrator

2. Collaborations


3. Activities and Findings



4. Publications

4.1 Journals

  1. Tsai H, Cheng J, Chang H, Yamamoto T, Shen A. Uniform electric field generation in circular multi-well culture plates using polymeric inserts. Sci Rep 19;6:26222,2016
  2. Chang H, Hoshina N, Zhang C, Ma Y, Cao H, Wang Y, Wu D, Bergen E, Landén M, Hultman C, Preisig M, Kutalik Z, Castelao E, Grigoroiu-Serbanescu M, Forstner A, Strohmaier J, Hecker J, Schulze T, Müller-Myhsok B, Reif A, Mitchell P, Martin N, Cichon S, Nöthen M, The Swedish Bipolar Study Group, MooDS Bipolar Consortium, Walter H, Erk S, Heinz A, Meyer-Lindenberg A, Tost H, Xiao X, Yamamoto T, Rietschel M, Li M. The Protocadherin 17 Gene Affects Cognition, Personality, Amygdala Structure and Function, Synapse Development and Risk of Major Mood Disorders. Mol Psychiatr, in press
  3. Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K, Yao I, Yamada A, Hata Y, Okumura N, Yamamoto T, Sakimura K, Takao T, and Ito S. Involvement of brain-enriched guanylate kinase-associated protein (BEGAIN) in chronic pain after peripheral nerve injury. eNeuro 10.1523/ENEURO.0110-16,2016.
  4. Ban T, Sato G R ,Nishiyama A, Akiyama A, Takasuna M, Umehara M, Suzuki S, Ichino M, Matsunaga S, Kimur A, Kimura Y, Yanai H, Miyashita S, Kuromitsu J, Tsukahara K,Yoshimatsu K, Endo I, Yamamoto T, Hirano H, Ryo A, Taniguchi T, and Tamura T. Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity. Immunity 45(2):319-32,2016.
  5. Ohashi T, Yamamoto T, Yamanashi Y, Ohsugi M. Human TUBG2 gene is expressed as two splice variant mRNAs and involved in cell growth. FEBS 590(8):1053-63,2016
  6. Zhang Q, Yan D, Guo E, Ding B, Yang W, Liu R, Yamamoto T and Bartlam M. Structural basis for inhibition of the deadenylase activity of human CNOT6L. FEBS letters 590(8):1270-9,2016
  7. Zukeran A, Takahashi A, Takaoka S, Mohamed H, Suzuki T, Ikematsu S, Yamamoto T, The CCR4-NOT deadenylase activity contributes to generation of induced pluripotent stem cells. BBRC 474(2):233-9,2016
  8. Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N,  Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, and Kano M. Emerging Roles of ARHGAP33 in Intracellular Trafficking of TrkB and Pathophysiology of Neuropsychiatric Disorders. Nat Commun 7:10594, 2016

4.2 Books and other one-time publications

Nothing to report

4.3 Oral and Poster Presentations

  1. Yamamoto T. The CCR4-NOT deadenylase: a key player of novel paradigm of gene regulation. Seminar at RIKEN Yokohama
  2. Yamamoto T. Roles of the CCR4-NOT deadenylase in regulation of energy metabolism. Tokyo Medical and Dental University
  3. Yamamoto T. Physiology and function of CCR4-NOT deadenylase complexni. BMB2015, Kobe Port Island
  4. Yamamoto T. Energy metabolism and CCR4-NOT dependent RNA degradation. Symposium for Future Drug Discovery and Medical Care Innovation, Kindai University
  5. Yamamoto T. Roles of CCR4-NOT deadenylase in regulation of energy metabolism. Akita University
  6. Yamamoto T. Roles of CCR4-NOT deadenylase in regulation of energy metabolism. Protein & Cell Symposium 2015, Institute of Biophysics, Chinese Academy of Sciences
  7. Takahashi A. Yamamoto T. Analysis of adenine nucleotide metabolism regulated by the CCR4-NOT complex. RNA Meeting 2015, Hotel Lifort Sapporo
  8. Suzuki T. Structural formation of mammalian CNOT complex and its role in liver development. The 4th CCR4-NOT meeting, Convention Hall Taizan, Akita Hotspring Satomi
  9. Takahashi A, Suzuki T, Yamamoto T. Significance of mRNA decay in maintenance of liver homeostasis. RNA Meeting 2015, Hotel Lifort Sapporo
  10. Takahashi A. Poly(A) tail length regulates mRNA expression homeostasis. The 4th CCR4-NOT meeting, Convention Hall Taizan, Akita Hotspring Satomi
  11. Suzuki T, Takahashi A, Yamamoto T. CNOT3 suppression promotes necrosis by stabilizing mRNAs for cell death-inducing proteins. RNA Meeting 2015, Hotel Lifort Sapporo
  12. Shirai Y, Yamamoto T. Functional analysis of CNOT3 in lung cancer progression. The 74th Annual Meeting of the Japanese Cancaer Association, Nagoya Congress Center
  13. Montrose K, Hoshina N, Yamamoto T. The role of LMTK3 in the CNS. BMB 2015, Kobe Port island
  14. Takahashi A, Yamamoto T. Regulation of Egfr expression by CNOT8 in the liver. RNA Meeting 2015, Hotel Lifort Sapporo
  15. Kureha T. CNOT3 is involved in the regulation of TCR signal in thymocyte. The 4th CCR4-NOT meeting, Convention Hall Taizan, Akita Hotspring Satomi
  16. Kureha T, Yamamoto T. The CCR4-NOT complex subunit CNOT3, is required for T cell maturation through dampening TCR-induced stress response. BMB2015, Kobe Port Island
  17. Kureha T, Yamamoto T. CNOT3 is important for thymocyte development through the regulation of TCR-mediated cell death signaling. East Asia joint Symposium on Biomedical Research, OIST

5. Intellectual Property Rights and Other Specific Achievements

Nothing to report

6. Meetings and Events

1. Seminar

Title: Elucidation of the molecular mechanisms of tumorigenesis by identification of novel cancer-associated genes-the PHLDA3 gene is a novel tumor suppressor gene of neuroendocrine tumors-

Date: April 8, 2016

Venue: C016, Lab1

Speaker: Prof. Rieko Ohki

Affiliation: Division of Rare Cancer Research, National Cancer Center Research Institute

2. Seminar

Title: Novel approaches to study mechanism of cytokinesis in animal cells.

Date: April 22, 2015

Venue: C016, Lab1

Speaker: Issei Mabuchi.

Affiliation: Dept. Life Science, Gakushuin University, Tokyo

3. Seminar

Title: microRNAs trigger dissociation of eIF4AI and II from target mRNAs in humans

Date: April 28, 2015

Venue: C016, Lab1

Speaker: Toshinobu Fujiwara

Affiliation: Faculty of Pharmacy, Kindai University

4. Seminar

Title: Digital counting of mRNA molecules genome-wide by molecular barcoding

Date: July 9, 2015

Venue: C016, Lab1

Speaker: Yutaka Yoshida

Affiliation: Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center

5. Seminar

Title: Translational control by poly(A)-binding protein during glucose-stimulated insulin biosynthesis in mouse pancreatic islets

Date: October 30, 2015

Venue: D015, Lab1

Speaker: Akiko Yanagiya

Affiliation: Goodman Cancer Research Centre, McGill University, Montreal, Quebec, CANADA

6. Seminar

Title: Abnormal activation of transcription factor NF-kB by oncoprotein of Human T cell leukemia Virus 1 (HTLV-1)

Date: February 24, 2016

Venue: C015, Lab1

Speaker: Jun-ichiro Inoue

Affiliation: Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo

7. Seminar

Title: Signaling by WW Domain Proteins in Hippo-YAP Tumor Suppressor Pathway, Mechanotransduction and a Genetic Disorder of the Brain

Date: March 2, 2016

Venue: C015, Lab1

Speaker: Marius Sudol.

Affiliation: Institute of Molecular and Cell Biology (IMCB) A*STAR, Mechanobiology Institute, Department of Physiology, National University of Singapore, Singapore

8. Seminar

Title: Mechanisms of androgen action in hormone-dependent and advanced hormone-refractory prostate cancer

Date: March 23, 2016

Venue: C700, Lab3

Speaker: Satoshi Inoue

Affiliation: Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo / Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University / Department of Functional Biogerontrogy, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan