1. Matsuura K, Kobayashi S, Konno K, Yamasaki M, Horiuchi T, Senda T, Hayashi T, Satoh K, Arima-Yoshida F, Iwasaki K, Negishi L, Yasui-Shimizu N, Kohu K, Kawahara K, Kirino Y, Nakamura T, Watanabe M, Yamamoto T, Manabe T, and Akiyama T.  SIPA1L1/SPAR1 interacts with the neurabin family of proteins and is involved in GPCR signaling. J. Neuroscience, in press.


  1. *Suzuki T, Hoshina M, Nishijima S, Hoshina, N, Kikuguchi C, Tomohiro T, Fukao A, Fujiwara T, and *Yamamoto T. Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2. RNA Biology, in press.
  2. Akiyama T, Yamamoto T. Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex. Front Immunol, 12:715675, 2021
  3. Takaoka S, Yanagiya A, Mohamed H, Higa R, Abe T, Inoue K, Takahashi A, Stoney P and Yamamoto T. Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis. iScience, ​24(10):103151, 2021
  4. Ban T, Kikuchi M, Sato G, Manabe A, Tagata N,  Harita K, Nishiyama A, Nishimura K, Yoshim Ri, Kirino Y, Yanai H, Matsumoto Y, Suzuki S, Hihara H, Ito M, Tsukahara K, Yoshimatsu K, Yamamoto T, Taniguchi T, Nakajima H, Ito S, and Tamura T. Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease. Nature Communications, 12:4379, 2021
  5. Minegishi K, Rothé B, Komatsu K, Ono H, Ikawa Y, Nishimura H, Katoh T, Kajikawa E, Sai X, Miyashita E, Takaoka K, Bando K, Kiyonari H, Yamamoto T, Saito H, Constam D, and Hamada H. Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex. Nature Communications, 12:4071, 2021
  6. Akiyama T, Suzuki T, Yamamoto T.  RNA decay machinery safeguards immune cell development and immunological responses. Trends Immunol., 42:447-460, 2021


  1. Suzuki T, Adachi S, Kikuguchi C, Shibata S, Nishijima S, Kawamoto Y, Iizuka Y, Koseki H, Okano H, Natsume T, Yamamoto T. Regulation of fetal genes by transitions among RNA-binding proteins during liver development. Int. J. Mol. Sci. 21(23), 9319, 2020
  2. Ito-Kureha T, Miyao T, Nishijima S, Suzuki T, Kozumi S-I, Villar-Brioness A, Takahashi A, Akinama N, Morita M, Nagura I, Ishikawa H, Ichijo H, Akinama T*, Yamamoto T*. The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression. Nature Commun., 11(1):6169, 2020
  3. Mostafa D, Yanagiya A, Georgiadou E, Wu Y, Stylianides T, Rutter GA, Suzuki T*, Yamamoto T*. Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation. Communications Biology, 3(1):476, 2020
  4. Vares G, Ahire V, Sunada S, Kim E, Sai S, Chevalier F, Romeo P, Yamamoto T, Nakajima T, Saintigny Y. A multimodal treatment of carbon ions irradiation, miRNA-34 and mTOR inhibitor specifically control high-grade chondrosarcoma cancer stem cells. Radiotherapy and Oncology, 150:253-261, 2020
  5. Otsuka H, Fukao A, Tomohiro T, Adachi S, Suzuki T, Takahashi A, Funakami Y, Natsume T, Yamamoto T, Duncan K, Fujiwara T. ARE-binding Protein ZFP36L1 Interacts With CNOT1 to Directly Repress Translation via a Deadenylation-Independent Mechanism. Biochimie, 174:49-56, 2020
  6. Sugawara S, Kanamaru Y, Sekine S, Maekawa L, Takahashi A, Yamamoto T, Watanabe K, Fujisawa T, Hattori K, Ichijo H. The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1. J Biol Chem, 295(17) 5588-5601, 2020
  7. Takahashi A, Suzuki T, Soeda S, Takaoka S, Kobori S, Yamaguchi T, Mohamed H, Yanagiya A, Abe T, Shigeta M, Furuta Y, Kuba K, and Yamamoto T. The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation. Life Science Alliance, 3(5):e201900494, 2020
  8. Mostafa D, Takahashi A, Yanagiya A, Yamaguchi T, Abe T, Kureha T, Kuba K, Kanegae Y, Furuta Y, Yamamoto T*, Suzuki T*. Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. RNA Biology, 17(3):403-416, 2020
  9. Nerome K, Ito-Kureha T, Paganini T, Fukuda T, Igarashi Y, Ashitomi H, Ikematsu S, Yamamoto T. Potent and broad anticancer activities of leaf extracts from Melia azedarach L. of the subtropical Okinawa islands. Am J Cancer Res, 10(2):581-594,2020
  10. Suzuki T, Kikuguchi C, Nishijima S, Yamamoto T. Insufficient liver maturation affects murine early postnatal hair cycle. Biochemical and Biophysical Research Communications, 521:172-177, 2020


  1. Baba M, Yokoyama K, Seiriki K, Naka Y, Matsumura K, Kondo M, Yamamoto K,  Hayashida M,  Kasai A, Ago Y, , Nagayasu K, Hayata-Takana A, Takahashi A, Yamaguchi S, Mori D,  Ozaki N, Yamamoto T, Takuma K, Hashimoto R, Hashimoto  H, Nakazawa T. Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome. Neuropsycopharacology, 44:2125-2135, 2019
  2. Takahashi A, Takaoka S, Kobori S, Yamaguchi T, Ferwati S, Kuba K, Yamamoto T*, Suzuki T*. The CCR4-NOT deadenylase complex maintains adipocyte identity. Int. J. Mol. Sci. 20: 5274, 2019
  3. Montrose K, Kobayashi S, Manabe T, Yamamoto T. Lmtk3-KO mice display a range of behavioural abnormalities and have an impairment in GluA1 trafficking. Neuroscience, 414:154-167, 2019
  4. Ashworth W, Stoney P, Yamamoto T. States of Decay: The Systems Biology of mRNA Stability. Current Opinion in Systems Biology. 15:48-57, 2019
  5. Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N. Hepatic post-transcriptional network comprising of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. Proc Nat Acad Sci USA, 116:7973-7981, 2019
  6. Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T. CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development. Oncogene, 38:2580-2594, 2019
  7. Suzuki T, Kikuguchi C, Nishijima S, Nagashima T, Takahashi A, Okada M, Yamamoto T. Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Development, 146:dev168146, 2019


  1. Chang H, Hoshina N, Zhang C, Ma Y, Cao H, Wang Y, Wu D, Bergen E, Landén M, Hultman C, Preisig M, Kutalik Z, Castelao E, Grigoroiu-Serbanescu M, Forstner A, Strohmaier J, Hecker J, Schulze T, Müller-Myhsok B, Reif A, Mitchell P, Martin N, Cichon S, Nöthen M, The Swedish Bipolar Study Group, MooDS Bipolar Consortium, Walter H, Erk S, Heinz A, Meyer-Lindenberg A, Tost H, Xiao X, Yamamoto T, Rietschel M and Li M. The Protocadherin 17 Gene Affects Cognition, Personality, Amygdala Structure and Function, Synapse Development and Risk of Major Mood Disorders. Mol Psychiatry 23:400-412, 2018
  2. Yamaguchi T, Suzuki T, Sato T, Takahashi A, Watanabe H, Kadowaki A, Miyuki N, Inagaki H, Arakawa S, Nakaoka S, Koizumi Y, Seki S, Adachi S, Fukao A, Fujiwara T, Natsume T, Kimura A, Komatsu M, Shimizu S, Ito H, Suzuki Y, Penninger JM, Yamamoto T, Imai Y and Kuba K. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Science signaling, 11:eaan3638, 2018


  1. Li T, Amari T, Semba K, Yamamoto T and Takeoka S. Construction and evaluation of pH-sensitive immunoliposomes for enhanced delivery of anticancer drug to ErbB2 over-expressing breast cancer cells. Nanomedicine 13(3):1219-1227,2017
  2. Li X, Morita M, Kikuguchi C, Takahashi A, Suzuki T and Yamamoto T. Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy. FEBS Letters 591(2):358-368,2017


  1. Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K, Yao I, Yamada A, Hata Y, Okumura N, Yamamoto T, Sakimura K, Takao T and Ito S. Involvement of brain-enriched guanylate kinase-associated protein (BEGAIN) in chronic pain after peripheral nerve injury. eNeuro 10:1523, 2016
  2. Ban T, Sato G R ,Nishiyama A, Akiyama A, Takasuna M, Umehara M, Suzuki S, Ichino M, Matsunaga S, Kimur A, Kimura Y, Yanai H, Miyashita S, Kuromitsu J, Tsukahara K,Yoshimatsu K, Endo I, Yamamoto T, Hirano H, Ryo A, Taniguchi T and Tamura T. Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity. Immunity 45(2):319-332,2016
  3. Tsai H, Cheng J, Chang H, Yamamoto T and Shen A. Uniform electric field generation in circular multi-well culture plates using polymeric inserts. Sci Rep 6:26222,2016
  4. Zukeran A, Takahashi A, Takaoka S, Mohamed H, Suzuki T, Ikematsu S and Yamamoto T. The CCR4-NOT deadenylase activity contributes to generation of induced pluripotent stem cells. BBRC 474(2):233-239,2016
  5. Ohashi T, Yamamoto T, Yamanashi Y and Ohsugi M. Human TUBG2 gene is expressed as two splice variant mRNAs and involved in cell growth. FEBS letters 590(8):1053-1063,2016
  6. Zhang Q, Yan D, Guo E, Ding B, Yang W, Liu R, Yamamoto T and Bartlam M. Structural basis for inhibition of the deadenylase activity of human CNOT6L. FEBS letters 590(8):1270-1279,2016
  7. Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N,  Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M and Kano M. Emerging Roles of ARHGAP33 in Intracellular Trafficking of TrkB and Pathophysiology of Neuropsychiatric Disorders. Nat Commun 7:10594, 2016


  1. Takahashi A , Adachi S ,Morita M , Tokumasu M , Natsume T , Suzuki T, and Yamamoto T , Post-Transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity. Cell Rep 13(12):2756-2767,2015
  2. Bai Y, Tashiro S, Nagatoishi S, Suzuki T, Yan D, Tsumoto K, Bartlam M, Yamamoto T, Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach. Protein Cell 6(12): 924–928,2015
  3. Suzuki T, Kikuguchi C, Sharma S, Sasaki T, Tokumasu M, Adachi S, Natsume T, Kanegae Y, and Yamamoto T. CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins. Sci Rep 5:14779,2015
  4. Inoue T, Morita M, Hijikata A, Fukuda-Yuzawa Y, Adachi S, Isono K, Ikawa T, Kawamoto H, Koseki H, Tohru N, Fukao T, Ohara O, Yamamoto T, Kurosaki T. CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability. J Exp Med 212:1465-79, 2015
  5. Ito-Kureha T, Koshikawa N, Yamamoto M, Semba K, Yamaguchi N, Yamamoto T, Seiki M, and Inoue J. Tropomodulin 1 expression driven by NF-κB enhances breast cancer growth. Cancer Research, 1;75(1):62-72,2015


  1. Knox R, Brennan-Milnella Angela, Lu F, Yang D, Nakazawa T, Yamamoto T, Swanson R, Ferriero D, and Jiang X, NR2B phosphorylation at Tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia. Stroke, 45(10):3040-7, 2014
  2. Shirai YT, Suzuki T, Morita M, Takahashi A, Yamamoto T, Multifunctional roles of the mammalian CCR4-NOT complex in physiological phenomena. Frontiers in Genetics,21;5:286, 2014
  3. David O, Barrera I, Adaikkan C, Kaphzan H, Nakazawa T, Yamamoto T and Rosenblum K, Dopamine-induced tyrosine phosphorylation of NR2B (Tyr1472) is essential for ERK1/2 activation and processing of novel taste information. Frontiers in Mol Neuroci, 18;7:66,2014
  4. Inoue T, Hoshina N, nakazawa T, Kiyama Y, Abe T, Yamamoto T, Manabe T, and Yamamoto T. LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking. J Neurosci 34(17): 5927-5937,2014
  5. Watanabe C, Morita M, Hayata T, Nakamoto T, Kikuguchi C, Li X, Kobayashi Y, Takahashi N, Notomi T, Moriyama K, Yamamoto T, Ezura Y, Noda M. The stability of mRNA influences osteoporotic bone mass via Cnot3. Proc Natl Acad Sci USA 111: 2692-2697, 2014


  1. Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T,and Yamamoto T. Protocadherin 17 Regulates Presynaptic Assembly in Topographic Cortico-Basal Ganglia Circuits. Neuron 78:839-54, 2013
  2. Kohda K, Kakwgawa W, Matsuda S, Yamamoto T, Hirano H, Yuzaki M. The δ2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites. Proc Natl Acad Sci U S A.  110(10):E948-57, 2013
  3. Yanagida S, Taniue K, Sugimasa H, Nasu E, Takeda Y, Kobayashi M, Ochiai K, Yamamoto T, Okamoto A, Akiyama T. ASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian clear cell carcinoma. Sci Rep.3:1305, 2013
  4. Sekino-Suzuki N, Yuyama K,Miki T, Kaneda M, Suzuki H, Yamamoto N, Yamamoto T, Oneyama C, Kasahara K. Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones. J Neurochem. 124(4):514-22, 2013


  1. Takahashi A, Morita M, Yokoyama K, Suzuki T, Yamamoto T. Tob2 inhibits PPARg2 expression by sequestering Smads and C/EBPa during adipocyte differentiation. Mol. Cell. Biol. 32: 5067-5077, 2012
  2. Suzuki T, Tsuzuku J, Hayashi A, Shiomi Y, Iwanari H, Mochizuki Y, Hamakubo T, Kodama T, Nishitani H, Masai H, Yamamoto T. Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob. J Biol Chem. 287: 40256-40265, 2012
  3. Takeshita K, Tezuka T, Isozaki Y, Yamashita E, Suzuki M, Kim M, Yamanashi Y, Yamamoto T, Nakagawa A., Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c. J Biochem. 152:487-495. 2012
  4. Ozaki Y, Matsui H, Asou H, Nagamachi A, Aki D, Honda H, Yasunaga S, Takihara Y, Yamamoto T, Izumi S, Ohsugi M, and Inaba T, Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation. Mol Cell. 2012 Sep 14;47(5):694-706.
  5. Unezaki S, Sasaki A, Mabuchi T, Matsumura S, Katano T, Nishio N, Andoh T, Nakazawa T, Yamamoto T, Nakatsuka T, Kuraishi Y, and Ito S, Involvement of Tyr1472 phosphorylation of NMDA receptor NR2B subunit in postherpetic neuralgia in model mice. Mol Pain. 21;8(1):59,2012
  6. Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Wada E, Wada K, Manabe T, Yamamoto T, and Nakazawa T. NMDAR2B tyrosine phosphorylation is involved in thermal nociception. Neurosci. Lett. 516: 270-273,2012
  7. Ohi K, Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, and Takeda M. The p250GAP gene is associated with risk for schizophrenia and schizotypal personality trait. PLoS ONE 7: e35696 ,2012
  8. Takahashi A, Kikuguchi C, Morita M, Shimodaira T, Tokai-Nishizumi N, Yokoyama K, Ohsugi M, Suzuki T, Yamamoto T.Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression. Biochem Biophys Res Commun. 419,268-73,2012
  9. Yang K, Trepanier C, Sidhu B, Xie YF, Li H, Lei G, Salter MW, Orser BA, Nakazawa T, Yamamoto T, Jackson MF, Macdonald JF. Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases. EMBO J. 31,805-16,2012
  10. Yoshikawa S, Kukimoto-Niino M, Parker L, Handa N, Terada T, Fujimoto T, Terazawa Y, Wakiyama M, Sato M, Sano S, Kobayashi T, Tanaka T, Chen L, Liu ZJ, Wang BC, Shirouzu M, Kawa S, Semba K, Yamamoto T, Yokoyama S. Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor. Oncogene ,32(1):27-38,2012


  1. Saito M., Kumazawa K, Doi A, Takebe S, Amari T, Oyama M, Semba K, Yamamoto T. ErbB2/HER2, its contribution to basic cancer biology and development of molecular targeted therapy. In "Breast Cancer Cells, Book 1" (ed. Gunduz M), INTECH, 2011
  2. Masuda N, Shimodaira T, Shiu SJ, Tokai-Nishizumi N, Yamamoto T, Ohsugi M. Microtubule stabilization triggers the plus-end accumulation accumulation of Kif18/kinesin-8. Cell Struct Funct, 2, 261-267, 2011
  3. Fabian MR, Cieplak MK, Frank F, Morita1 M, Green J, Srikumar T, Nagar B, Yamamoto T, Raught B, Duchaine TF and Sonenberg N. miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nat Struct and Mol Biol, 18,1211-7,2011
  4. Ito K, Takahashi A, Morita M, Suzuki T, and Yamamoto T, The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability. Protein & Cell, 2, 755-763, 2011
  5. Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta Y, Sudo K, Watanabe K, Iwakur Y and Yamamoto T. NYAP: a phosphoprotein family that links PI3K to WAVE1 signaling in neurons. EMBO J, 30, 4739-4754, 2011
  6. Morita M, Oike Y, Nagashima T, Kadomatsu T, Tabata M, Suzuki T, Nakamura T, Yoshida N, Okada M, and Yamamoto T. Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice. EMBO J, 30, 4678-4691, 2011
  7. Chen C, Ito K, Takahashi A, Wang G, Suzuki T, Nakazawa T, Yamamoto T, Yokoyama K. Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development. Biochem Biophys Res Commun.411:360-4. 2011
  8. Suzuki T, Kim M, Kozuka-Hata H, Watanabe M, Oyama M, Tsumoto K, Yamamoto T. Monoubiquitination of Tob/BTG family proteins competes with degradation-targeting polyubiquitination. Biochem Biophys Res Commun. 409:70-4. 2011
  9. Ito K, Inoue T, Yokoyama K, Morita M, Suzuki T, and Yamamoto T. CNOT2-depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death. Genes to Cells 4: 368-79, 2011
  10. Katano T, Nakazawa T, Nakatsuka T, Watanabe M, Yamamoto T, & Ito S. Involvement of spinal phosphorylation cascade of Tyr1472-NR2B, Thr286-CaMKII, and Ser831-GluR1 in neuropathic pain. Neuropharmacol. 60:609-16, 2011
  11. Hino N, Oyama M, Sato A, Mukai T, Iraha F, Hayashi A, Kozuka-Hata H, Yamamoto T, Yokoyama S, Sakamoto K. Genetic incorporation of a photo-crosslinkable amino acid reveals novel protein complexes with GRB2 in mammalian cells. J Mol Biol 406: 343-353, 2011


  1. Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattor S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T. NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala. Molecular Brain 3: 37, 2010
  2. Tasaki S, Nagasaki M, Kozuka-Hata H, Semba K, Gotoh N, Hattori S, Inoue J, Yamamoto T, Miyano S, Sugano S, and Oyama M. Phosphoproteomics-based modeling defines the regulatory mechanism underlyingaberrant EGFR signaling. PLoS ONE 5: e13926, 2010
  3. Chagnon MJ, Wu CL, Nakazawa T, Yamamoto T, Noda M, Blanchetot C, Tremblay ML. Receptor tyrosine phosphatase sigma (RPTPsigma) regulates, p250GAP, a novel substrate that attenuates Rac signaling. Cell Signal. 22: 1626-1633, 2010
  4. Matsumura S, Kunori S, Mabuchi T, Katano T, Nakazawa T, Abe T, Watanabe M, Yamamoto T, Okuda-Ashitaka E and Ito S. Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472. Eur J Neurosci 32: 7989-810, 2010
  5. Wang H, Morita M, Yang X, Suzuki T, Yang W, Wang J, Ito K, Wang Q, Zhao C, Bartlam M*, Yamamoto T* & Rao Z. Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity. EMBO J 29: 2566-2576, 2010
  6. Koshiba S, Li H, Motoda Y, Tomizawa T, Kasai T, Tochio N, Yabuki T, Harada T, Watanabe S, Tanaka A, Shirouzu M, Kigawa T, Yamamoto T, Yokoyama S. Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2. J Struct Funct Genomics. 11:125-141, 2010
  7. Bartlam M, Yamamoto T. The structural basis for deadenylation by the CCR4-NOT complex. Protein & Cell 1: 443-452, 2010
  8. Watanabe M, Suzuki T, Kim M, Abe Y, Yoshida Y, Sugano S and Yamamoto T. Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. FEBS Lett. 585: 65-70, 2010


  1. Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy PN, Hashimoto K, Kano M, Manabe T, Yamamoto T. Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior. EMBO J. 28: 3817-3829, 2009
  2. Futatsumori-Sugai M, Abe R, Watanabe M, Kudou M, Yamamoto T, Ejima D, Arakawa T, Tsumoto K. Utilization of Arg-elution method for FLAG-tag based chromatography. Protein Expr Purif. 67: 148-155, 2009
  3. Matsumura T, Kawamura-Tsuzuku J, Yamamoto T, Semba K and Inoue J. TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is a negative regulator of the TRAF6-induced cellular functions. J Biochem, 146: 375-381, 2009
  4. Oshimori N, Li X, Ohsugi M, Yamamoto T. Cep72 regulates localization of key centrosomal proteins and proper bipolar spindle formation. EMBO J 28: 2066-2076, 2009
  5. Kawa S, Matsushita H, Ohbayashi H, Semba K, and Yamamoto T. A novel mouse monoclonal antibody targeting ErbB2 suppresses breast cancer growth. Biochem Biophys Res Commun, 384: 329-333, 2009
  6. Horiuchi M, Takeuchi K, Noda N, Muroya N, Suzuki T, Nakamura T, Kawamura-Tsuzuku J, Takahasi T, Yamamoto T and Inagaki F. Structural basis for the antiproliferative activity of the Tob-hCaf1 complex. J Biol Chem 284:13244-13255, 2009
  7. Miyai K, Yoneda M, Hasegawa U, Toida S, Izu Y, Hiroaki H, Hayata T, Ezura Y, Mizutani S, Miyazono K, Akiyoshi K, Yamamoto T, Noda M, ANA deficiency enhances BMP-induced ectopic bone formation via transcriptional events. J Biol Chem 284: 10593-10600, 2009
  8. Kakugawa S, Shimojima M, Goto H, Horimoto T, Oshimori N, Neumann G, Yamamoto T, and Kawaoka Y. Mitogen-Activated Protein Kinase-Activated Kinase RSK2 Plays a Role in Innate Immune Responses to Influenza Virus Infection. J Virol 83: 2510?2517, 2009
  9. Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, Kakuta S, Sudo K, Iwakura Y, Shibutani M, Mitsumori K, Yokota J and Yamamoto T. Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Cancer Sci 100: 225-232, 2009
  10. Oyama M, Kozuka-Hata H, Tasaki S, Semba K, Hattori S, Sugano S, Inoue J and Yamamoto T. Temporal perturbation of tyrosine-phosphoproteome dynamics reveals the system-wide regulatory networks. Mol Cell Prot, 8:226-231, 2009
  11. Suzuki T, Tsuzuku J, Kawakami K, Miyasaka T and Yamamoto T. Proteasome-mediated degradation of Tob is pivotal for triggering UV-induced apoptosis. Oncogene 28:401-11.2009


  1. Yang X, Morita M, Wang H, Suzuki T, Yang W, Luo Y, Zhao C, Bartlam M, Yamamoto T and Rao Z. Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity. Nucl Acids Res ;36(21):6872-81, 2008
  2. Isosaka T, Hattori K, Kida S, Kohno T, Nakazawa T, Yamamoto T, Yagi T and Yuasa S. Activation of Fyn tyrosine kinase in the mouse dorsal hippocampus is essential for contextual fear conditioning. Eur J Neurosci 28(5):973-81, 2008
  3. Goto J, Tezuka T, Nakazawa T, Sagara H, and Yamamoto T. Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development. Mol Cell Neurosci 38: 203-212, 2008
  4. Nakazawa T, Kuriu T, Tezuka T, Umemori H, Okabe S, and Yamamoto T. Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP. J. Neurochem 105: 1384-1393, 2008
  5. Ajima R, Akiyama T, Usui M, Yoneda M, Yoshida Y, Nakamura T, Minowa O, Noda M, Tanaka S, Noda T, and Yamamoto T. Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation. FEBS Lett 582:1313-1318, 2008
  6. Miyasaka T, Morita M, Ito K, Suzuki T, Fukuda H, Takeda S, Inoue J, Semba K and Yamamoto T. Interaction of anti-proliferative protein Tob with the CCR4-NOT deadenylase complex. Cancer Science 99: 755-761, 2008
  7. Ohsugi M, Adachi K, Horai R, Kakuta S, Sudo K, Kotaki H, Tokai-Nishizumi N, Sagara H, Iwakura Y, and Yamamoto T. Kid-mediated chromosome compaction ensures proper nuclear envelop formation. Cell 132: 771-782, 2008
  8. Tahara K, Takagi M, Ohsugi M, Sone T, Nishiumi F, Maeshima K, Horiuchi Y, Tokai-Nishizumi N, Imamoto F, Yamamoto T, Kose S, and Imamoto N. Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid. J Cell Biol 180: 493-506. 2008
  9. Haraguchi K, Ohsugi M, AbeY, Semba K, Akiyama T, and Yamamoto T. Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3b-mediated phosphorylation of b-catenin. Oncogene 27: 274-284. 2008


  1. Hoshina N, Tezuka T, Yokoyama K, Kozuka-Hata H, Oyama M and Yamamoto T. Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth. Genes to Cells. 12: 1245-1254, 2007
  2. Kina S, Tezuka T, Kusakawa S, Kishimoto Y, Kakizawa S, Hashimoto K, Ohsugi M, Kiyama Y, Horai R, Sudo K, Kakuta S, Iwakura Y, Iino M, Kano M, Manabe T, Yamamoto T. Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. Eur J Neurosci. 26(8):2269-78. 2007
  3. Yamaguchi R, Wada E, Kamichi S, Yamada D, Maeno H, Delawary M, Nakazawa T, Yamamoto T, and Wada K. Neurotensin type 2 receptor in astrocytes is involved in fear memory in mice. J. Neurochem. 102: 1669-1676. 2007
  4. Inoue A, Yasuda T, Yamamoto T, Yamanashi Y. Dok-1 is a positive regulator of IL-4 signaling and IgE response. J Biochem. 142: 257-263, 2007
  5. Bai C, Ohsugi M, Abe Y, Yamamoto T. ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions. J. Cell Sci. 120: 2828-2837, 2007
  6. Washio-Oikawa K, Nakamura T, Usui M, Yoneda M, Ezura Y, Ishikawa I, Kazuhisa N, Noda T, Yamamoto T, and Noda M. Cnot7 null mice exhibit high bone mass phenotype and modulation of BMP action. J Borne Mineral Res, 22: 1217-23, 2007
  7. Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, & Yamamoto T. Depletion of mammalian CCR4b deadenylasetriggers increment of the p27Kip1 mRNA level and impaires cell growth. Mol. Cell. Biol. 27: 4980-4990, 2007
  8. Oyama M, Kozuka-Hata H, Suzuki Y, Semba K, Yamamoto T and Sugano S. Diversity of translation start sites may define increased complexity of the human short ORFeome. Mol. Cell. Proteomics 6: 1000-1006, 2007
  9. Delawary M, Nakazawa T, Tezuka T, Sawa M, Iino Y, Takenawa T, and Yamamoto T. Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 357:377-82, 2007
  10. Chikamori, M., Fujimoto, J., Tokai-Nishizumi, N., and Yamamoto, T. Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation. Oncogene 26:2950-2954, 2007
  11. Yasuda T, Bundo K, Hino A, Honda K, Inoue A, Masaki S, Osawa M, Tamura T, Nariuchi H, Oda H, Yamamoto T and Yamanashi Y. Dok-1 and Dok-2 are negative regulators of T cell receptor signaling. Int Immunol. 19: 487-496, 2007
  12. Saito A, Nagasaki M, Oyama M, Kozuka-Hata H, Semba K, Sugano S, Yamamoto T, and Miyano S. AYUMS: an algorithm for completely automatic quantitation based on LC-MS/MS proteome data and its application to the analysis of signal transduction. BMC Bioinformatics 8: 15, 2007


  1. Kawa, S., Ito, C., Toyama, Y., Maekawa, M., Tezuka, T., Nakamura, T., Nakazawa, T., Yokoyama, K., Yoshida, N., Toshimori, K., and Yamamoto, T. Zoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/ lemur tyrosine kinase 2) gene. Proc Natl Acad Sci USA 103: 19344-19349, 2006
  2. Yokoyama, K., Tezuka, T., Hoshina, N., Nakazawa, T., and Yamamoto, T. Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases. Biochem. Biophys. Res. Commun. 349: 1401-1405, 2006
  3. Xu F, Plummer MR, Len GW, Nakazawa T, Yamamoto T, Black IB, and Wu K. Brain-derived neurotrophic factor rapidly increases NMDA receptor channel activity throu gh Fyn-mediated phosphorylation. Brain Res. 1121: 22-34, 2006
  4. Huang L, Watanabe M, Chikamori M, Kido Y, Yamamoto T, Shibuya M, Gotoh N and Tsuchida N. Unique role of SNT-2/FRS2β/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways. Oncogene 25: 6457-6466, 2006
  5. Oshimori N, Ohsugi M and Yamamoto T. The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity. Nature Cell Biol. 8: 1095-1101, 2006
  6. Washio-Okikawa K, Nakamura T, Usui M, Yoneda M, Ezura Y, Ishikawa I, Nakashima K, Yamamoto T and Noda M. Expression Analysis of LacZ gene placed in the locus of Cnot7 exhibits its activity in osteoblasts in vivo and in mineralized nodules in vitro. J. Cell Biochem. 99: 538-544, 2006
  7. Hiramatsu Y, Kitagawa K, Suzuki T, Uchida C, Hattori T, Kikuchi H, Oda T, Hatakeyama S, Nakayama K I. , Yamamoto T, Konno H and Kitagawa M. Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination. Cancer Research 66: 8477-8483, 2006
  8. Liu H, Nakazawa T, Tezuka T and Yamamoto T. Physical and functional interaction of FYN tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP. J. Biol. Chem. 281: 23611-23619, 2006
  9. Nakazawa T, Komai S, Watabe AM, Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T and Manabe T. NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J. 25: 2867-2877, 2006
  10. Abe Y, Ohsugi M, Haraguchi K, Fujimoto J, and Yamamoto T. LATS2-Ajuba complex regulates γ-tubulin recruitment to centrosomes and spindle organization during mitosis. FEBS LETTER 580: 782-788, 2006
  11. Haraguchi K, Hayashi T, Jimbo T, Yamamoto T and Akiyama T. Role of the kinesin-2 family protein, KIF3, during mitosis. J. Biol. Chem. 281: 4094-4099, 2006


  1. Vo N, Klein ME, Varlamova O, Keller DM, Yamamoto T, Goodman RH, and Impey S. A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc. Natl. Acad. Sci. USA 102: 16426-16431, 2005
  2. Tokai-Nishizumi N, Ohsugi M, Suzuki E, and Yamamoto T. The chromokinesin Kid is required for maintenance of proper metaphase spindle size. Mol. Biol. Cell 16: 5455-5463, 2005
  3. Suzuki M, Mimuro H, Suzuki T, Park M, Yamamoto T, and Sasakawa C. Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. J. Exp. Med. 202: 1235-1247, 2005
  4. Abe T., Matsumura S., Katano T., Mabuchi T, Takagi K, Xu. L, Yamamoto A., Hattori K., Yagi T., Watanabe M., Nakazawa T., Yamamoto T., Mishina M., Nakai Y., and Ito S., Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur. J. Neurosci. 22: 1445-1454, 2005
  5. Nishida K, Yamasaki S, Ito Yukitaka, Kabu K, Hattori K, Tezuka T, Nishizumi H, Kitamura D, Goitsuka R, S.Geha R, Yamamoto T, Yagi T, and Hirano T. FcεRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J.C.B. 170: 115-126, 2005
  6. Ito Y, Suzuki T, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Yamamoto T, Miyauchi A. Phosphorylation and inactivation of Tob contributes to the progressionof papillary carcinoma of the thyroid. Cancer Lett. 220: 237-242, 2005
  7. Kitajima T. S., Hauf S., Ohsugi M., Yamamoto T., Watanabe Y. Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization. Current Biology 15: 353-359, 2005
  8. Shinohara H, Inoue A, Toyama-Sorimachi N, Yasuda T, Suzuki H, Horai R, Iwakura Y, Yamamoto T, Karasuyama H, Miyake K and Yamanashi Y. Dok-1 and Dok-2 are negative regulators of LPS-induced signaling. J. Exp. Med. 201: 333-339, 2005
  9. Okochi, K., Suzuki, T., Inoue, J., Matsuda, S., and Yamamoto, T. Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control. Genes to Cells. 10: 151-163, 2005


  1. Yasuda T, and Yamamoto T. Analysis of B-cell signaling using DT40 B-cell line. Methods Mol Biol. 271: 261-270, 2004
  2. Yasuda T, Shirakata M, Iwama A, Ishii A, Ebihara Y, Osawa M, Honda K, Shinohara H, Sudo K, Tsuji K, Nakauchi H, Iwakura Y, Hirai H, Oda H, Yamamoto T and Yamanashi Y. Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J. Exp. Med. 200: 1681-1687, 2004
  3. Ogawa T, Ito C, Nakamura T, Tamura Y, Yamamoto T, Noda T, Kubota Y, Toshimori K. Abnormal sperm morphology caused by defects in Sertoli cells of Cnot7 knockout mice. Archives of Histology and Cytology 67: 307-314, 2004
  4. Suetsugu S, Tezuka T, Morimura T, Hattori M, Mikoshiba K, Yamamoto T, Takenawa T: Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1. Biochem J. 384: 1-8, 2004
  5. Huang L, Goto N, Zhang S, Shibuya M, Yamamoto T, and Tsutida N. SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. BBRC 324: 1011-1017, 2004
  6. Kawamura-Tsuzuku J, Suzuki T, Yoshida Y and Yamamoto T. Nuclear localization of Tob is important for regulation of its anti-proliferative activity. Oncogene 23: 6630-6638, 2004
  7. Motegi A, Fujimoto J, Kotani M, Sakuraba H, and Yamamoto T. ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth. J Cell Sci. 117: 3319-3329, 2004
  8. Nakamura T, Yao R, Ogawa T, Suzuki T, Ito C, Tsunekawa N, Inoue K, Ajima R, Miyasaka T, Yoshida Y, Ogura A, Toshimori K, Noce T, Yamamoto T, and Noda T. Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nature Genetics 36: 528-533, 2004
  9. Usui M, Yoshida Y, Tsuji K, Oikawa K, Miyazono K, Ishikawa I, Yamamoto T, Nifuji A, and Noda M. Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. Proc Nat Acad Sci USA. 101: 6653-6658, 2004
  10. Moon B, Takaki S, Nishizumi H, Yamamoto T, and Takatsu K. Abrogation of autoimmune disease in Lyn-deficient mice by the deletion of IL-5 receptor α chain gene. Cellular Immunology 228: 110-118, 2004
  11. Kawa S, Fujimoto J, Texzuka T, Nakazawa T, and Yamamoto T. Involvement of BREK, a novel dual-specificity kinase enriched in brain, in NGF signaling. Genes to Cells 9: 219-232, 2004
  12. Kim M, Tezuka T, Tanaka K, and Yamamoto T. Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. Oncogene. 23: 1645-1655, 2004
  13. Goto J, Tezuka T, Nakazawa T, Tsukamoto N, Nakamura T, Ajima R, Yokoyama K, Ohta T, Ohki M, and Yamamoto T. Altered gene expression in the adult brain of fyn-deficient mice. Cell. Mol. Neurobiol. 24: 149-159, 2004


  1. Iwanaga K, Sueoka N, Sato A, Sakuragi T, Sakao Y, Tominaga M, Suzuki T, Yoshida Y, K-Tsuzuku J, Yamamoto T, Hayashi S, Nagasawa K, and Sueoka E. Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer. Cancer Lett. 202: 71-79, 2003
  2. Nakazawa T, Watabe AM, Tezuka T, Yoshida Y, Yokoyama K, Umemori H, Inoue A, Okabe S, Manabe T, and Yamamoto T. p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the NMDA receptor signaling. Mol. Biol. Cell 14 : 2921-2934, 2003
  3. Taniguchi S, Liu H, Nakazawa T, Yokoyama K, Tezuka T, and Yamamoto T. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. Biochem. Biophys. Res. Commun. 306: 151-155, 2003
  4. Shiroguchi K, Ohsugi M, Edamatsu M, Yamamoto T, Toyoshima YY. The second microtubule-binding site of monomeric kid enhances the microtubule affinity. J Biol Chem. 278: 22460-22465, 2003
  5. Yoshida Y, Nakamura T, Komoda M, Sato H, Tsuzuku JK, Miyasaka T, Yoshida EH, Umemori H, Kunisaki RK, Tani K, Ishii S, Mori S, Suganuma M, Noda T, and Yamamoto T. Mice lacking a transcriptional corepressor Tob are predisposed to cancer. Genes & Dev. 17: 1201-1206, 2003
  6. Ohsugi M, Nishizumi NT, Shiroguchi K, Toyoshima YY, Inoue J, and Yamamoto T. Cdc2-mediated phosphorylation of chromokinesin Kid controls its distribution to spindle and chromosomes. EMBO J. 22: 2091-2103, 2003
  7. Yoshida Y, von Bubnof A, Ikematsu N, Blitz IL, Tsuzuku JK, Yoshida EH, Umemori H, Miyazono K, Yamamoto T, and Cho KWY. Tob proteins enhance inhibitory-smad-receptor interaction to repress BMP signaling. Mech Dev. 120: 629-637, 2003
  8. Umemori H, Ogura H, Tozawa N, Mikoshiba K, Nishizumi H, and Yamamoto T. Impairment of N-methyl-D-aspartate receptor-controlled motor activity in Lyn-deficient mice. Neurosci .118: 709-713, 2003
  9. Kuo ML, Duncavage EJ, Mathew R, den Besten W, Pei D, Naeve D, Yamamoto T, Cheng C, Sherr CJ, Roussel MF; Arf induces p53-dependent and independent anti-proliferative genes. Cancer Res. 63: 1046-1053, 2003
  10. Alvestad RM, Grosshans DR, Coultrap SJ, Nakazawa T, Yamamoto T, and Browning MD, Tyrosine dephosphorylation and ethanol inhibition of NMDA receptor function. J Biol Chem. 278: 11020-11025, 2003
  11. Yajima J, Edamatsu M, Watai-Nishi J, Tokao-Nishizumi N, Yamamoto T, Toyoshima YY, The human chromokinesin Kid is a plus-end directed microtubule-based motor. EMBO J. 22 5: 1067-1074, 2003


  1. Suetsugu S, Hattori M, Miki H, Tezuka T, Yamamoto T, Mikoshiba K, Takenawa T. Sustained activation of N-WASP through phosphorylation is essential for neurite extension. Dev Cell. 5:645-658, 2002
  2. Gurd JW, Bissoon N, Beesley PW, Nakazawa T, Yamamoto T, and Vannucci SJ. Differential effects of hypoxia-ischemia on subunit expression and tyrosine phosphorylation of the NMDA receptor in 7- and 21-day-old rats. J. Neurochem. 82: 848-856, 2002
  3. Yasuda T, Tezuka T, Maeda A, Inazu T, Yamanashi Y, Gu H, Kurosaki T, and Yamamoto T. Cbl-b positively regulates Btk-mediated activation of phospholipase C-γ2 in B cells. J. Exp. Med. 196: 51-63, 2002
  4. Kono H, Suzuki T, Yamamoto K, Okada M, Yamamoto T, and Honda Z. Spatial raft coalescence represents an initial step in Fc gamma R signaling. J. Immunol 169: 193-203, 2002
  5. Suzuki T, K-Tsuzuku J, Ajima R, Nakamura T, Yoshida Y, and Yamamoto T. Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation. Genes & Dev 16: 1357-1370, 2002
  6. Naito A, Yoshida H, Nishioka E, Satoh M, Azuma S, Yamamoto T, Nishikawa S, and Inoue J. TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. Proc Natl Acad Sci U S A. 99:8766-71, 2002.
  7. Usui M, Yoshida Y, Yamashita T, Tsuji T, Ishikawa I, Yamamoto T, Nifuji A, and Noda M. Enhancing dfect of Tob deficiency on bone formation is spesific to BMP-induced osteogenesis. J. Bone Miner. Res. 17:1026-33, 2002
  8. Hashimoto R, Hough C, Nakazawa T, Yamamoto T, and Chuang De-Maw. Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: Involvement of NMDA receptor inhibition by decreasing NR2B tyrosine phosphorylation. J. Neurochem. 80:589-97, 2002
  9. Kitagawa D, Tanemura S, Ohata S, Shimizu N, Seo J, Nishitani G, Watanabe T, Nakagawa K, Kishimoto H, Wada T, Tezuka T, Yamamoto T, Nishina H and Katada T. Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation. J. Biol. Chem. 277:366-71, 2002
  10. Yokoyama K, Su I-hsin, Tezuka T, Yasuda T, Mikoshiba K, Tarakhovsky A, and Yamamoto T. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor. EMBO J. 21:83-92, 2002
  11. Kohno M, Hasegawa H, Miyake M, Yamamoto T, and Furuta S. CD151 Enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase. Int. J. Cancer 97:336-343, 2002


  1. Akiyama T, Gohda J, Shibata S, Nomura Y, Azuma S, Ohmori Y, Sugano S, Arai H, Yamamot T, and Inoue J. Mammalian homologue of E. coli ras-like GTPase (ERA) is a possible apiptosis regulator with RNA binding activity. Genes Cells 6: 987-1001, 2001
  2. Della Ragione F, Criniti V, Della Pietra V, Borriello A, Oliva A, Indaco S, Yamamoto T, Zappia V.   Genes modulated by histone acetylation as new effectors of butyrate activity. FEBS Lett 499: 199-204, 2001
  3. YoshidaY, Hosoda E, Nakamura T, and Yamamot T. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. Jpn. J. Cancer Res. 92: 592-596, 2001
  4. Rascan I M, and Yamamoto T. B cell receptor signaling involves physical and functional association of FAK with Lyn and IgM. FEBS Letters 498: 26-31, 2001
  5. Kobayashi N, Kadono Y, Naito A, Matsumoto K, Yamamoto T, Tanaka S, and Inoue J. Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J. 20:1271-80, 2001
  6. Suzuki T, Matsuda S, Tsuzuku J. K, Yoshida Y, and Yamamoto T. A serine/threonine kinase p90rsk1 phosphorylates the antiproliferative protein Tob. Genes Cells 6:131-138, 2001
  7. Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, Mishina M, Manabe T, Yamamoto T. Characterization of Fyn-mediated tyrosine phosphorylation sites on GluRε2 (NR2B) subunit of the N-methyl-D-aspartate receptor. J Biol Chem. 276, 693-699, 2001
  8. Miki S, Horikawa K, Nishizumi H, Sato B, Yamamoto M, Takatsu K, Yamamoto T, and Miki Y. Reduction of artherosclerosis despite hypercholestrolemia in lyn-deficient mice fed a high-fat-diet. Genes Cells 6: 37-42, 2001


  1. Yoshida Y, Sakae T, Umemori H, Minowa O, Usui M, Ikematsu N, Hosoda E, Imamura T, Kuno J, Yamashita T, Miyazono K, Noda M, Noda T, and Yamamoto T. Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell 103, 1085-1097, 2000
  2. Sein T. T, Thant A. A, Hiraiwa Y, Amin A. R, Sohara Y, Liu Y, Matsuda S, Yamamoto T, and Hamaguchi M. A role of FAK in the concanavalin A-dependent secretion of matrix metalloproteinase-2 and-9. Oncogene 19: 5539-5542, 2000
  3. Ajima R, Ikematsu N, Ohsugi M, Yoshida Y, and Yamamoto T. Cloning and characterization of the mouse tob2 gene. Gene 253: 215-220, 2000
  4. Suzuki T, Kono H, Hirose N, Okada M, Yamamoto T, Yamamoto K, and Honda Z. Differential involvement of Src family kinases in Fcγ receptor-mediated phagocytosis. J. Immunol. 165: 473-482, 2000.
  5. M. Sharma K, S. Garg B, Kurosaki H, Goto M, Otsuka M, Yamamoto T, and Inoue J. Aurine Tricarboxylic Acid, a potent metal-chelating inhibitor of NFκB-DNA binding. Bioorg. Med. Chem. 8:1819-1823, 2000
  6. Hironaka K, Umemori H, Tezuaka T, and Yamamoto T. The protein-tyrosine phosphatase PTPMEG interacts glutamate receptor delta 2 and epsilon subunits. J. Biol. Chem. 275:16167-16173, 2000.
  7. Honda Z, Suzuki T, Kono H, Okada M, Yamamoto T, Ra C, Morita Y, and Yamamoto K. Sequential requirements of the N-Terminal palmitoylation site and SH2 comain of Src family kinases in the initiation and progression of FcεRI signaling. Mol. Cel. Biol. 20:1759-1771, 2000.
  8. Martins-Green M, L. Bixby J, Yamamoto T, Graf T, and Sudol M. Tissue specific expression of Yrk kinase: implications for differentiation and inflammation. Int’l. J. Biochem. and Cell Biol. 32: 351-364, 2000.
  9. Yasuda T, Maeda A, Kurosaki M, Tezuka T, Hironaka K, Yamamoto T, and Kurosaki T. Cbl suppresses B cell receptor-mediated phospholipase c-g2 activation by regulating BLNK-PLC-g2 binding. J. Exp. Med. 191:641-650, 2000.
  10. Inoue J, Ishida T, Tsukamoto N, Kobayashi N, Naito A, Azuma S, and Yamamoto T. Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediated cytokine signaling. Exp. Cell Res. 254: 14-24, 2000.
  11. Yamanashi Y, Tamura T, Kanamori T, Yamane H, Nariuchi H, Yamamoto T and David B. Role of the rasGAP-associated docking protein p62dok in negative regulation of B cell receptor-mediated signaling. Genes & Dev. 14:11-16, 2000.


  1. Umemori H, Hayashi T, Inoue T, Nakanishi S, Mikoshiba K, and Yamamoto T. Involvement of protein tyrosine phosphatase in activation of the trimeric G protein Gq/11. Oncogene 18: 7399-7402 1999.
  2. Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Fujimoto J, and Yamamoto T. Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. Oncogene 18: 7432-7441, 1999.
  3. Hisatsune C, Umemori H, Mishina M, and Yamamoto T. Phosphorylation-dependent interaction of the N-methyI-D-aspartate receptor e2 subunit with phosphatidylinositol 3-kinase. Genes Cells 4: 657-666 1999.
  4. Fujimoto J, Sawamoto K, Okabe M, Takagi Y, Tezuka T, Yoshikawa S, Ryo H, Okano H, and Yamamoto T. Cloning and characterization of dfak56, a homolog of focal adhesion kinase, in drosophila melanogaster. J. Biol. Chem. 274: 29196-29201, 1999.
  5. Kim M, Tezuka T, Suzuki Y, Sugano S, Hirai M, and Yamamoto T. Molecular cloning and characterization of a novel cbl-family gene, cbl-c. Gene 239: 145-154, 1999.
  6. Horikawa K, Nishizumi H, Umemori H, Aizawa S, Takatsu K, and Yamamoto T. Distinctive roles of Fyn and Lyn in IgD- and IgM-magma-Mediated signaling. Int’l Immunol. 11: 1441-1449, 1999.
  7. Muto Y, Hayashi T, Higashi Y, Endo T, Yamamoto T, and Sato K. Age-related decrease in brain-derived neurotrophic factor gene expression in the brain of the zitter rat with genetic spongiform encephalophathy. Neuroscience Letters 271:69-72, 1999
  8. Naito A, Azuma S, Tanaka S, Miyazaki T, Takaki S, Takatsu K, NakaoK, Nakamura K, Katsuki M, Yamamoto T, and Inoue J. Severe osteopetrosis, devective interleukin-1 signaling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4: 353-362, 1999.
  9. J. Caughey D, O. Narhi L, Kita Y, Y. Meng S, Wen D, Chen W, J. Ratzkin B, Fujmoto J, Iwahara T, Yamamoto T, and Arakawa T. Fractionation of polyclonal antibodies to fragments of a neuroeceptor using three increasingly chaotropic solvents. J. Chromatogr. B. Biomed. Sci. Appl. 728: 49-57, 1999.
  10. Narisawa-Saito M, J. Silva A, Yamaguchi T, Hayashi T, Yamamoto T, and Nawa H. Growth factor-mediated Fyn signaling regulates AMPA receptor expression in rodent neocortical neurons. Proc. Natl. Acad. Sci. USA 96: 2461-2466 1999
  11. Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Proc. Natl. Acad. Sci. USA 96: 1234-1239, 1999.
  12. Umemori H, Kadowaki Y, Hirosawa K, Yoshida Y, Hironaka K, Okano H, and Yamamoto T. Stimulation of Myelin Basic Protein Gene Transcription by Fyn Tyrosine Kinase for Myelination. J. Neuroscience 19: 1393-1397, 1999.
  13. Tezuka T, Umemori H, Akiyama T, Nakanishi S, and Yamamoto T. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc. Natl. Acad. Sci. USA 96: 435-440, 1999
  14. Hayashi T, Umemori H, Mishina M, and Yamamoto T. The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn. Nature 397: 72-76, 1999


  1. Li T, O. Narhi L, Wen J, S. Philo J, Sitney K, Inoue J, Yamamoto T, and Arakawa T. Interactions between NFkB and its inhibitor ikB: biophysical characterization of a NFkB/ikB-a complex. Protein Chem. 17: 757-763, 1998.
  2. Sano Y, Tokitou F, Dai P, Maekawa T, Yamamoto T, and Ishii S. CBP activates the intramolecular inhibition of ATF-2 function. J. Biol. Chem. 273: 29098-29105, 1998
  3. Suzuki T, Shoji S, Yamamoto K, Nada S, Okada M, Yamamoto T, and Honda Z. Essential roles of Lyn in fibronectin-meiated filamentous-actin assembly and cell motility in mast cells. J. Immunol. 161: 3964-3701, 1998.
  4. Miyatake A, Nakaseko C, Umemori H, Yamamoto T, and Saito T. Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152), Biochem Biophys Res Commun. 249, 444-448, 1998
  5. Kametani Y, Goto H, Kobori A, Sato T, Ando K, Hozumi K, Nishimura T, Saito T, Yamamoto T, and Habu S. Ex vivo evidence for asymmetric tyrosine phosphorylation of ZAP-70 on double-positive thymocytes in the positive selection process. Int’l Immunol. 10:1203-1210, 1998
  6. Takeda H, Matozaki T, Fujioka Y, Takeda T, Noguchi T, Yamao T, Tsuda M, Ochi F, Fukunaga K, Narumiya S, Yamamoto T, and Kasuga M. Lysophosphatidic acid-induced association of SHP-2 with SHPS-1: roles of RHO, FAK, and a SRC family kinase. Oncogene 16: 3019-3027, 1998.
  7. Tsuda M, Matozaki T, Fukunaga K, FujiokaY, InamotoA, Noguchi T, Takada T, Yamao T, Takeda H, Ochi F, Yamamoto T, and Kasuga M. Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. J. Biol. Chem. 273: 13223-13229, 1998.
  8. YoshidaY, Matsuda S, K-Tsuzuku J, Ikematsu N, Inzawa J, Umemori H, and Yamamoto T. ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system. Oncogene 16: 2687-2693, 1998.
  9. Nishizumi H, Horikawa K, Mlinaric-Rascan I, and Yamamoto T. A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals. J. Exp. Med. 187: 1343-1348, 1998.
  10. KohnoT, Kawanishi M, Matsuda S, Ichikawa H, Takada M, Ohki M, Yamamoto T, and Yokota J. Homozygous Deletion and Frequent Allelic loss of the 21q11.1-q21.1 region including the ANA gene in human lung carcinoma. Gene, Chromosomes & Cancer 21:236-243, 1998.
  11. Suzuki K, Tsuchida J, Yamamoto T, and Inoue J. Identification and expression of the Xenopus homolog of mammalian p100-NFkB2. Gene 206: 1-9, 1998
  12. Mizushima S, Fujita M, Ishida T, Azuma S, Kato K, Hirai M, Otsuka M, Yamamoto T, and Inoue J. Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). Gene 207: 135-140, 1998
  13. Kashiwada M, Shirakata Y, Inoue J, Nakano H, Okazaki K, Okumura K, Yamamoto T, Nagaoka H, and Takemori T. Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-negulated kinase (ERK) activity in CD40 signaling along a Ras-independent pathway. J. Exp. Med. 187: 237-244, 1998.


  1. Ohsugi M, Kuramochi S, Matsuda S, and Yamamoto T. Molecular cloning and characterization of a novel cytoplasmic protein-tyrosine phosphatase that is specifically expressed in spermatocytes. J. Biol. Chem. 272: 33092-33099, 1997
  2. Kasahara K, Watanabe Y, Yamamoto T, and Sanai Y. Association of Src family tyrosine kinase Lyn with ganglioside GD3 in rat brain. J. Biol. Chem. 21: 29947-29953, 1997
  3. Baba M, Kikuchi Y, Mori S, Kimoto H, Inui S, Sakaguchi N, Inoue J, Yamamoto T, Takemori T, Howard M, and Takatsu K. Mouse germinal center B cells with the xid mutation retain responsiveness to anti-mouse CD40 antibodies but diminish IL-5 responsiveness. Int. Immunol. 9: 1463-1473, 1997
  4. Yasue T, Nishizumi H, Miyake K, Aizawa S, Yamamoto T, Uehara S, Kikuchi Y, and Takatsu K. IgG1 production induced by CD38 ligation and IL-5 require activation of Fyn and Lyn kinases. Proc. Natl. Acad. Sci. USA 94: 10307-10312, 1997
  5. Hisatsune C, Umemori H, Inoue T, Michikawa T, Kohda K, Mikoshiba K and Yamamoto T. Phosphorylation-dependent regulation of NMDA receptors by calmodulin. J. Biol. Chem. 272:20805-20810, 1997
  6. Ilic D, Kanazawa S, Nishizumi H, Aizawa S, Kuroki T, Mori S, and Yamamoto T. Skin abnormality in aged fyn-1- fak+/- mice. Carcinogenesis 18:1473-1476, 1997
  7. Fujimoto-Nishiyama A, Ishii S, Matsuda S, Inoue J, and Yamamoto T. A novel zinc finger protein Finb is a trascriptional activator and localized in nuclear bodies. Gene 195: 267-275, 1997
  8. Umemori H, Inoue T, Kume S, Sekiyama N, Nagao M, Itoh H, Nkanishi S, Mikoshiba K, and Yamamoto T. Activation of the G protein Gq/11 through tyrosine phosphorylation of the a subunit. Science 276:1878-1881, 1997
  9. Yoshida Y, Matsuda S, and Yamamoto T. Cloning and characterization of the mouse tob gene. Gene 191:109-113, 1997
  10. Yamanashi Y, Fukuda T, Nishizumi H, Inazu T, Higashi K, Kitamura D, Ishida T, Yamamura H, Watanabe T, and Yamamoto T. Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis. J. Exp. Med. 185:1387-1392, 1997
  11. Nishizumi H, and Yamamoto T. Impaired Ca2+ mobilization but not degranulation in Lyn deficient bone marrow-derived mast cells. J. Immunol. 158:2350-2355, 1997
  12. Matsuda Y, Saito T, Fujimoto J, and Yamamoto T. Chromosomal mapping of the mouse and rat brt genes. Genomics 40: 181-184, 1997
  13. Ilic D, H. Damsky C, and Yamamoto T. Focal adhesion kinase at the crossroads of signal transduction. J.Cell Sci. 110: 401-407, 1997
  14. Iwahara T, Fujimoto J, Wen D, Cupples R, Bucay N, Arakawa T, Mori S, Ratzkin B, and Yamamoto T. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene 14: 439-449, 1997
  15. Saito T, Matsuda Y, Ito H, Fusaki N, Hori T, and Yamamoto T. Localization of ZAP-70, the gene for a T cell-specific protein tyrosine kinase, to mouse and rat chromosomes by fluorescence in situ hybridization and molecular genetic linkage analyses. Mammalian Genome 8:45-66, 1997
  16. Otsuka M, Fujita M, Sugiura Y, Yamamoto T, Inoue J, Maekawa T, and Ishii S. Synthetic inhibitors of regulatory proteins involved in the signaling pathway of the replication of human immunodeficiency virus 1. Bioorg. Med. Chem. 5:205-215, 1997