Implications of ERBB2 amplification


Wednesday, February 27, 2019 - 13:00 to 14:00


C016 (Lab1, Level C)


Dear All,

Cell Signal Unit (Yamamoto Unit) would like to inform you of a seminar by Dr. Kentaro Semba from Waseda University.



Date: Wednesday, February 27, 2019

Time: 13:00-14:00

Venue: C016, Level C, Lab 1



Dr. Kentaro Semba, Waseda University

Implications of ERBB2 amplification

Gene amplification is one of major genetic alterations in human cancers. Amplified genomic regions, called amplicons, usually contain “driver” genes that are responsible for tumorigenesis, for example, EGFR, ERBB2, or MYC. Co-amplified genes in the same amplicon as a driver gene  have been thought to be “passenger” genes that do not play important roles in cancer cells, therefore, they have not been studied extensively so far. Previously we reported that an adaptor protein-encoding gene GRB7 was coamplified with ERBB2 gene in the same amplicon and cooperatively transformed NIH3T3 cells with ERBB2. In this talk I will about another example, HNF-1B in the same amplicon as a putative oncogenic and metastatic-promoting gene.

Prof. Tadashi Yamamoto


We hope to see many of you at the seminar.


Best regards,

Yuki Nakagawa

Research Unit Administrator

Cell Signal Unit

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