Translational Control of Cancer and Neurological Diseases via eIF4E

Dear All,

Cell Signal Unit (Yamamoto Unit) would like to inform you of a seminar by Dr. Nahum Sonenberg from McGill University.

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Date: Monday, February 4, 2019

Time: 13:30-14:30

Venue: C210, Level C, Center

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Speaker:

Dr. Nahum Sonenberg, McGill University

Title:
Translational Control of Cancer and Neurological Diseases via eIF4E

Abstract:
Translational control plays a critical role in essential cellular processes including cell growth, proliferation, development, and learning and memory.  Under most circumstances, translational control is exerted at the initiation step in which the eukaryotic translation initiation factor 4E (eIF4E) interacts with the mRNA 5’cap structure to facilitate the recruitment of ribosomes and promote translation. Importantly, eIF4E preferentially stimulates the translation of a subset of mRNAs. The activity of eIF4E is regulated chiefly by two major signalling pathways: PI3K/Akt/mTOR and Ras/MAPK/Mnk. mTOR directly phosphorylates the 4E-BPs (eIF4E-binding proteins), which are inhibitors of eIF4E, to relieve translational suppression, while Mnk phosphorylates eIF4E to stimulate translation. Aberrations in these pathways result in dysregulated eIF4E activity, which engenders cancer and neurological disorders such as autism, Fragile X Syndrome and depression.

Host:
Prof. Tadashi Yamamoto

We hope to see many of you at the seminar.

Best regards,

Yuki Nakagawa

Research Unit Administrator

Cell Signal Unit