山本 雅

  教授                     

理学博士 (大阪大学)

国籍

日本

受賞学術賞

研究経歴

• 米国ＮＩＨ 癌研究所 研究員   (1977年9月-1981年2月)
• 東京大学医科学研究所 助手    (1980年9月-1986年4月)
• 東京大学医科学研究所 助教授　(1986年4月-1911年11月)
• 東京大学医科学研究所 教授    (1991年11月-2012年3月)
• 東京大学医科学研究所 所長    (2003年4月-2007年3月)
• 東京大学評議員                         (2003年4月-2007年3月)
• 日本学術会議会員                     (2006年10月-2011年9月)
• 東京大学医科学研究所　癌・細胞増殖部門部門長　(2007年4月-2011年3月)
• 沖縄科学技術大学院大学 教授　(2012年4月-現在)
• 理化学研究所 統合生命医科学研究センター センター長　(2015年10月-2020年3月)
• 理化学研究所 統合生命医科学研究センター チームリーダー（2016年4月-現在）
• 沖縄科学技術大学院大学 副学長研究担当ディーン　(2019年4月-現在)

主要業績

• Yamaguchi T, Suzuki T, Sato T, Takahashi A, Watanabe H, Kadowaki A, Miyuki N, Inagaki H, Arakawa S, Nakaoka S, Koizumi Y, Seki S, Adachi S, Fukao A, Fujiwara T, Natsume T, Kimura A, Komatsu M, Shimizu S, Ito H, Suzuki Y, Penninger JM, Yamamoto T, Imai Y and Kuba K. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Science signaling 11(516):eaan3638. doi.10.1126/scisignal.aan3638, 2018.
• Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T. (2013) Protocadherin 17 Regulates Presynaptic Assembly in Topographic Cortico-Basal Ganglia Circuits. Neuron 78:839-854. (IF 14.318)
• Morita M, Oike Y, Nagashima T, Kadomatsu T, Tabata M, Suzuki T, Nakamura T, Yoshida N, Okada M, and Yamamoto T, Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice. EMBO J 30: 4678-4691, 2011
• Ohsugi M, Adachi K, Horai R, Kakuta S, Sudo K, Kotaki H, Tokai-Nishizumi N, Sagara H, Iwakura Y, and Yamamoto T. Kid-mediated chromosome compaction ensures proper nuclear envelop formation. Cell 132: 771-782, 2008
• Oshimori N, Ohsugi M and Yamamoto T. Kizuna, a new PLK1 target, stabilizes mitotic centrosomes to ensure spindle bipolarity. Nature Cell Biol 8:1095-1101, 2006
• Nakamura T, Yao R, Ogawa T, Suzuki T, Ito C, Tsunekawa N, Inoue K, Ajima R, Miyasaka T, Yoshida Y, Ogura A, Toshimori K, Noce T, Yamamoto T and Noda T, Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta, Nature Genetics 36: 528-533, 2004
• Yoshida Y, Nakamura T, Komoda M, Satoh H, Suzuki T, Kawamura-Tsuzuku J, Miyasaka T, Yoshida EH, Umemori H, Kunisaki RK, Tani K, Ishii S, Mori S, Suganuma M, Noda T, and Yamamoto T, Mice lacking a transcriptional corepressor Tob are predisposed to cancer, Genes & Dev. 17: 1201-1206, 2003
• Suzuki T, Kawamura-Tsuzuku J, Ajima R, Nakamura T, Yoshida Y, and Yamamoto T, Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation Genes & Dev 16: 1357-1370, 2002
• Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N, Hosoda E, Imamura T, Kuno J, Yamashita T, Miyazono K, Noda T, Noda M, and Yamamoto T. Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell 103: 1085-1097, 2000
• Hayashi T, Umemori H, Mishina M and Yamamoto T, The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn, Nature 397: 72-76, 1999
• Umemori H, Inoue T, Kume S, Sekiyama N, Nagao M, Itoh H, Nakanishi S, Mikoshiba K and Yamamoto T. Activation of the G protein Gq/11 through tyrosine phosphorylation of the a subunit. Science 276:1878-1881, 1997
• Nishizumi H, Taniuchi I, Yamanashi Y, Kitamura D, Ilic D, Mori S, Watanabe T and Yamamoto T, Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity 3: 549-560, 1995
• Ilic D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Nakatsuji N, Nomura S, Fujimoto J, Ikawa Y, Okada M, Yamamoto T, and Aizawa S, Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377: 539-544, 1995
• Umemori H, Sato S, Yagi T, Aizawa S, and Yamamoto T, Initial events of myelination involve Fyn tyrosine kinase signaling. Nature 367: 572-576, 1994
• Yamanashi Y, Kakiuchi T, Mizuguchi J, Yamamoto T and Toyoshima K, Associations of B cell antigen receptor and protein-tyrosine kinase p56lyn. Science 251: 192-194, 1991
• Miyajima N, Horiuchi R, Shibuya Y, Fukushige S, Matsubara K, Toyoshima K, and Yamamoto T, Two erbA homologs encoding proteins with different T3- binding capacities are transcribed from the opposite strands of the same genetics locus. Cell 57: 31-39, 1989
• Akiyama T, Sudo C, Ogawara H, Toyoshima K and Yamamoto T, The product of the human c-erbB-2 gene ; A 185,000 dalton glycoprotein associated with tyrosine kinase activity. Science 232: 1644-1646, 1986
• Yamamoto T, Ikawa S, Akiyama T, Semba K, Nomura N, Miyajima N, Saito T, and Toyoshima K, Similarity of protein encoded by the human c-erbB-2 gene to epidermal growth factor receptor. Nature 319: 230-234, 1986
• Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K. Location of the c-yes gene on the human chromosome and its expression in various tissues. Science 227:1038-1040, 1985
• Merlino GT, Xu Y-H, Ishii S, Clark AJL, Semba K, Toyoshima K, Yamamoto T and Pastan I, Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science 224: 417-419, 1984
• Yamamoto T, Nishida T, Miyajima N, Kawai S, Ooi T, and Toyoshima K, The erbB gene of avian erythroblastosis virus is a member of the src gene family. Cell 35: 71-78, 1983
• Yamamoto T, Hihara H, Nishida T, Kawai S, and Toyoshima K, A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erythroblastosis and sarcomas. Cell 34: 225-232, 1983
• Yamamoto T, de Crombrugghe B and Pastan I, Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus. Cell 22: 787-797, 1980

全発表論文

https://groups.oist.jp/ja/csu/full-publications-tadashi-yamamoto