Seminar"Exploring the potential applications of cell membrane in biohybrid devices"Emilio Satoshi Hara


2024年6月19日 (水) 13:30




Micro/Bio/Nanofluidics (Shen) Unit would like to invite you to the seminar by Prof. Emilio Satoshi Hara on June 19 (Wednesday).
Date:   June 19, 2024
Time:  13:30-14:30
Venue: L5D23, OIST


Emilio Satoshi Hara
Research Associate Professor
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Advanced Research Center for Oral and Craniofacial Sciences (ARCOCS), Okayama, Japan


Exploring the potential applications of cell membrane in biohybrid devices


The cell (plasma) membrane is composed of a phospholipid bilayer that forms a dynamic and flexible barrier essential for maintaining the structural integrity of cells and regulating their internal microenvironment. Numerous transmembrane or membrane-bound molecules, such as receptors, ligands, and enzymes, are attached to or integrated into the plasma membrane and play crucial roles in cell sensing and signaling; enabling the cells to detect and respond to external stimuli through signal transduction pathways. Therefore, the plasma membrane can be potentially exploited as a biofunctional membrane in diverse platforms.

We previously showed that plasma membrane nanofragments (PMNFs) act as nucleation sites for bone formation in vivo, and induce in vitro mineralization within 1 day (while live cells require at least 2 to 3 weeks) (ACS Biomater Sci & Eng, 2018; J Mater Chem B, 2018). Combining these PMNFs with electronically conducting polymers, we developed soft actuators that self-create bones (Adv Mater, 2022; Adv Mater Technol, 2023). We also exploited the application of PMNFs as core material to develop bone-on-chip platforms (Sci Technol Adv Mater, 2023; IEEE Biosensors, 2023).

In this talk, I will present these data and the concept behind the design and potential applications of using PMNFs in biohybrid materials/devices, including biosensors.

Prof. Amy Shen

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