Seminar"Exploring the potential applications of cell membrane in biohybrid devices"Emilio Satoshi Hara

Micro/Bio/Nanofluidics (Shen) Unit would like to invite you to the seminar by Prof. Emilio Satoshi Hara on June 19 (Wednesday).
 
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Date:   June 19, 2024
Time:  13:30-14:30
Venue: L5D23, OIST
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Speaker:

Emilio Satoshi Hara
Research Associate Professor
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Advanced Research Center for Oral and Craniofacial Sciences (ARCOCS), Okayama, Japan

Title:

Exploring the potential applications of cell membrane in biohybrid devices

Abstract:

The cell (plasma) membrane is composed of a phospholipid bilayer that forms a dynamic and flexible barrier essential for maintaining the structural integrity of cells and regulating their internal microenvironment. Numerous transmembrane or membrane-bound molecules, such as receptors, ligands, and enzymes, are attached to or integrated into the plasma membrane and play crucial roles in cell sensing and signaling; enabling the cells to detect and respond to external stimuli through signal transduction pathways. Therefore, the plasma membrane can be potentially exploited as a biofunctional membrane in diverse platforms.

We previously showed that plasma membrane nanofragments (PMNFs) act as nucleation sites for bone formation in vivo, and induce in vitro mineralization within 1 day (while live cells require at least 2 to 3 weeks) (ACS Biomater Sci & Eng, 2018; J Mater Chem B, 2018). Combining these PMNFs with electronically conducting polymers, we developed soft actuators that self-create bones (Adv Mater, 2022; Adv Mater Technol, 2023). We also exploited the application of PMNFs as core material to develop bone-on-chip platforms (Sci Technol Adv Mater, 2023; IEEE Biosensors, 2023).

In this talk, I will present these data and the concept behind the design and potential applications of using PMNFs in biohybrid materials/devices, including biosensors.

Host:
Prof. Amy Shen