OIST internal seminar
Date: 21st June, 2013 (Friday)
Time: 5:00 -6:00pm (refreshments will be served after the seminar)
Dr. Naosuke Hoshina (Cell Signal (Yamamoto) Unit)
Protocadherin 17 Regulates Presynaptic Assembly in Topographic Cortico-Basal Ganglia Circuits
Highly topographic organization of neural circuits exists for the regulation of various brain functions in the cortico-basal ganglia circuits. Although neural circuit-specific refinements during synapse development are essential for the establishment of particular neural functions, the molecular and cellular mechanisms for neural circuit-specific refinements of synapses are largely unknown. Here, we found that protocadherin 17 (PCDH17), one of the non-clustered δ2-protocadherin family members, is enriched along cortico-basal ganglia synapses in a zone-specific manner during early synaptogenesis stages, and regulates presynaptic assembly specifically in these synapses. PCDH17 deficiency in mice causes altered presynaptic vesicle accumulation and synaptic transmission in cortico-basal ganglia circuits. Furthermore, PCDH17－/－ mice exhibit antidepressant-like phenotype that is known to be regulated by the cortico-basal ganglia circuits. Our findings demonstrate a critical role for PCDH17 in the synaptic development of specific cortico-basal ganglia circuits and emphasize the importance of topographic cortico-basal ganglia circuitry in depressive behaviors.
Dr. Maxim Koroteev (Physics and Biology (Miller) Unit)