"Recent advances in rapid and highly sensitive detection of proteins and specific DNA sequences using a magnetic modulation biosensing system"Amos Danielli

Micro/Bio/Nanofluidics (Shen) Unit would like to invite you to the seminar by Prof. Amos Danielli on September 21st (Wednesday).
 
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Date: Wednesday, September 21, 2022
Time: 11:00-12:00
Venue: C700 (Lab 3)
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Speaker:
Amos Danielli
Professor
Faculty of Engineering, The Institute of Nanotechnology and Advanced Materials,
Bar-Ilan University, Israel

Title:
Recent advances in rapid and highly sensitive detection of proteins and specific DNA sequences using a magnetic modulation biosensing system

Abstract:

In early disease stages, biomolecules of interest exist in very low concentrations, presenting a significant challenge for analytical devices and methods. Here, we provide a comprehensive overview of an innovative optical biosensing technology, termed magnetic modulation biosensing (MMB), its biomedical applications, and its ongoing development. In MMB, magnetic beads are attached to fluorescently labeled target molecules. A controlled magnetic force aggregates the magnetic beads and transports them in and out of an excitation laser beam, generating a periodic fluorescent signal that is detected and demodulated. MMB applications include rapid and highly sensitive detection of specific nucleic acid sequences, antibodies, proteins, and protein interactions. Compared with other established analytical methodologies, MMB provides improved sensitivity, shorter processing time, and simpler protocols.

Biography:

Dr. Danielli is a senior lecturer and the head of the Optical Imaging and Biosensing lab at the Faculty of Engineering in Bar Ilan University. In 1997, 2002, and 2010, Dr. Danielli received his B.Sc., M.Sc., and Ph.D degrees in Electrical Engineering from Tel-Aviv University, Magna cum Laude. In 2009–2014, Dr. Danielli worked as a post-doctoral researcher at Washington University in St. Louis under the supervision of Prof. Lihong Wang. Dr. Danielli published multiple papers and patents in the field of biophotonics and biosensing. His research includes development of highly sensitive detection tools for biomarkers. Currently, he focuses on rapid and highly sensitive detection of viruses, such as SARS-CoV-2, Zika, dengue, and West-Nile. In addition, Dr. Danielli is the founder of MagBiosense, a medical device company that commercializes the technology that he developed.

Host:
Prof. Amy Shen