Seminar: Microsystems for Shaping and Sensing Cellular Interactions

Dr. Alexander Revzin, Professor, Department of Physiology and Biomedical Engineering Mayo Clinic, USA.

Title: Microsystems for Shaping and Sensing Cellular Interactions
Speaker: Prof. Alexander Revzin, Department of Physiology and Biomedical Engineering Mayo Clinic, USA
Date: November 25, Friday
Time: 2pm - 3pm
Venue: C209, Level C, Centre Building

Abstract: Traditionally, cells are analyzed by collecting media for off-dish functional assays such as ELISA.  Our lab has been interested in developing assays that may be miniaturized and placed at the site of small groups of cells for on-dish detection of cell function.  In developing these assays or biosensors we strive to achieve local and continuous detection of molecules appearing in extracellular space.  Three categories of biosensors for cell secreted molecules under development in our lab will be discussed: aptamer-based sensors for protein detection, peptide-based sensors for protease activity monitoring and enzyme-based biosensors for small metabolite analysis.  Applications of these technologies for tissue injury modeling and disease diagnosis will be discussed.