Amphipol Symposium 2016

Date

2016年2月15日 (月) 9:00 〜 2016年2月17日 (水) 17:00

Location

OIST Seaside House & Main Campus (Teaching Lab)

Description

Summary

Amphipols are an innovative class of surfactants developed with the view of improving the stability of membrane proteins in aqueous solutions. They are short and flexible amphipahtic polymers that carry many alkyl chains. They can substitute for detergents at the transmembrane surface of membrane proteins and stay associate to them even at extreme dilutions. After trapping in amphipols, membrane proteins are as a rule more stable biochemically than in detergent solutions, which increases the lifetime of fragile membrane proteins for the purpose of proteomics, structural and functional studies, and therapeutics. The rich chemistry of amphipols also allows modifications and labelling, generating a library of molecules that expand the scope of applications. This mini symposium will introduce the theory and practice for a good use of these unusual surfactants with the expertise of internationally highly regarded speakers.

Invited Speakers

Shin-ichi Aizawa (Hiroshima Pref. University): https://hiris.pu-hiroshima.ac.jp/profile/en.UPo9e3KJ6JT3p.3QSwwyoA==.html

Alison Ashcroft (University of Leeds, UK): http://www.astbury.leeds.ac.uk/people/staff/staffpage.php?StaffID=AEA

Melanie Cocco (University of California Irvine, USA): http://www.faculty.uci.edu/profile.cfm?faculty_id=4947

Jörg Kleinschmidt (University of Kassel, Germany): http://www.uni-kassel.de/fb10/institute/biologie/fachgebiete/biophysik/prof-dr-joerg-h-kleinschmidt.html
Werner Kühlbrandt (Max Plant Institute of Biophysics, Germany): http://www.biophys.mpg.de/de/kuehlbrandt.html

Martin Picard (CRP2, France): http://lcrbw.pharmacie.univ-paris5.fr/spip.php?article61&lang=fr

Jean-Luc Popot (IBPC, France): http://www.ibpc.fr/UMR7099

Manuela Zoonens (IBPC, France): http://www.ibpc.fr/UMR7099

(This list is subject to change. Thank you in advance for your understanding.)

Main organizer

Prof. Matthias Wolf, Molecular Cryo-Electron Microscopy Unit, OIST

Co-organizers