Seminar "Long-read de novo genome assembly of Xenopus species: A practical introduction" by Jessen V. Bredeson


Thursday, March 29, 2018 - 14:30 to 15:30


C210, Center Building


Molecular Genetics Unit (Rokhsar Unit) would like to invite you to a seminar by Jessen V. Bredeson from University of California, Berkeley

Title: Long-read de novo genome assembly of Xenopus species: A practical introduction

Genome assemblies are invaluable as platforms for enabling a wide array of biologically and agriculturally important analyses, including gene discovery and functional genomics, trait (including disease) mapping, population genetics, and genomic selection. The development of long-read sequencing technologies and chromosome conformation capture (Hi-C) techniques have alleviated the difficulties, and reduced the cost, of generating high-quality, near-finished chromosome-scale genome assemblies. Using Western Clawed Frog (Xenopus tropicalis) and African Clawed Frog (Xenopus laevis) PacBio datasets as examples, this talk will give an introduction to long-read assembly and the integration of Hi-C data, the benefits of combining multiple assemblies for improved overall contiguity, and publicly-available tools to facilitate the assembly process. Common obstacles encountered, prior to and after assembly, will be presented with practical advice offered to overcome them.

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