Virtual Seminar"Design and Development of MXene-Nanohybrid based Electrochemical biosensors for Bioanalytical applications"Y. Veera Manohara Reddy

Micro/Bio/Nanofluidics (Shen) Unit would like to invite you to the virtual seminar by Dr. Y. Veera Manohara Reddy on July 21  (Thursday).
 
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Date: July 21, 2022
Time: 10:00-10:30AM
**Zoom session
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*Zoom information

Join Zoom Meeting
https://oist.zoom.us/j/93726729386?pwd=Y3NmSFVuM3lmN3pDanJkKzZFMnZhdz09

Meeting ID: 937 2672 9386
Passcode: 452972

Speaker:

Dr. Y. Veera Manohara
Food-Biosensor & Theranosis Laboratory
Department of Food Science and Technology
Chung-Ang University, South Korea

Title:

Design and Development of MXene-Nanohybrid based Electrochemical biosensors for
Bioanalytical applications

Abstract:

MXene-Nanohybrid biosensors offer significant advantages for bioanalysis such as tiny reagent
and sample requirement, point-of-care, and high throughput analysis. These biosensors are
extremely useful in pathogens detection. The inclusion of MXenes and graphene during the
fabrication of immunosensors is expected to increase the surface area as well as the bioactivity of
immobilized antibodies/peptides on the electrode surfaces thereby improving detection sensitivity.
The presence (-OH) moieties on the surface of MXenes favors the functionalization by employing
silylation reagents. As a result, we employ such modification to the Ti3C2-MXene nanosheets to
uniformly pattern aminosilane moieties followed by NHS/EDC Coupling for the covalent
immobilization of bioreceptors for sensing applications such as virus detection.
My previous work focused on the evolution of an electrochemical sensor to detect various
biomolecules using rGO films incorporated with bimetallic nanoparticles and nanoparticles of
metal oxides as electrocatalysts. My results demonstrate that it is believed that the metal structure
would affect detection performance in terms of sensitivity, selectivity, stability, and
reproducibility. This is due to the different surfaces area, sizes and electronic properties that have
different metal particle structures. Therefore, future efforts should focus on the synthesis of rGO
@metal nanohybrids with various metallic nanostructures such as flowers, cubes, rods, and other
structures. The different structure metal control synthesis can be prepared by manipulating the pH
and introducing the surfactant and coating agent into the reaction mixture before undergoing a
hydrothermal process. It will be advantageous to discover how the anchoring of other materials,
such as metal oxides and bimetallic/monometallic nanoparticles, would affect the electrocatalytic
reaction with respect to the target analytes. Taking advantage of both materials in terms of
ecological and simple preparation protocol, will reduce production costs and could therefore be an
alternative material for the manufacture of the electrochemical biosensors

Host:

Prof. Amy Shen