Seminar"Optical modulation biosensing for rapid and highly sensitive detection of biomarkers at low resource settings"Amos Danielli


Tuesday, July 23, 2024 - 16:00




Micro/Bio/Nanofluidics (Shen) Unit would like to invite you to the seminar by Prof. Amos Danielli on July 23 (Tuesday).
Date:   July 23, 2024
Time:  16:00-17:00
Venue: B503, OIST


Amos Danielli
Associate Professor
Faculty of Engineering, The Institute of Nanotechnology and Advanced Materials
Bar Ilan University, Israel


Optical modulation biosensing for rapid and highly sensitive detection of biomarkers at low resource settings


Rapid, highly sensitive, and high-throughput detection of biomarkers at low concentrations is invaluable for the early diagnosis of various diseases. In many highly sensitive immunoassays, magnetic beads are used to capture fluorescently labeled target molecules. The target molecules are then quantified by detecting the fluorescent signal from individual beads, which is time-consuming and requires a complicated and expensive detection system. Here, I provide a comprehensive overview of an innovative optical modulation biosensing (OMB) technology, which uses a small permanent magnet to aggregate the beads into a small detection volume. Additionally, to subtract background noise from unbound fluorescent molecules, a laser beam is steered back and forth between the bead aggregate and the background solution, practically eliminating the need for washing and separation steps and facilitating the use of the technology in low-resource settings. Compared with other established analytical methodologies, OMB provides improved sensitivity, shorter processing time, and simpler protocols.


Prof. Danielli is an Associate Professor and the Head of the Optical Imaging and Biosensing Lab at the Faculty of Engineering, Bar Ilan University. He received his B.Sc., M.Sc., and Ph.D. degrees in Electrical Engineering from Tel-Aviv University, Magna cum Laude, in 1997, 2002, and 2010, respectively. From 2009 to 2014, Prof. Danielli conducted postdoctoral research at Washington University in St. Louis under the supervision of Prof. Lihong Wang. He has authored numerous papers and patents in the field of biophotonics and biosensing, focusing on the development of highly sensitive detection tools for biomarkers. Currently, his research is centered on the rapid and highly sensitive detection of viruses such as SARS-CoV-2, Zika, dengue, and West Nile. Visit his webpage at for more information.

Prof. Amy Shen

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