Seminar"Magnetic wires for active micro-rheology: applications to intra- and extra-cellular body fluids" Jean-Francois Berret


Monday, November 11, 2019 - 11:00


D015 (Level D, Lab1)


Micro/Bio/Nanofluidics (Shen) Unit would like to invite you to the seminar by Prof. Jean-Francois Berret on November 11 (Monday).
Date: Monday, November 11, 2019
Time: 11:00-12:00
Venue: D015 (Level D, Lab 1)


Prof. Jean-Francois Berret
CNRS (Centre national de la recherche scientifique)


Magnetic wires for active micro-rheology: applications to intra- and extra-cellular body fluids


In living environments, biological materials are often in a crowded state. Crowding has a strong impact on biological functions, as it restrains molecular motion, affects the flow and induces viscoelasticity. Here we address the question of the mechanical properties of living cells using a microrheology platform based on the video-microscopy tracking of magnetic wires. Wires are submitted to an external magnetic field of increasing frequencies. Extensive measurements performed on three cells lines confirm the viscoelastic character of the cytoplasm. With this microrheology platform, we also study on the effect of inhaled nanoparticles on extracellular body fluids, in particular on lung fluids and show that their bulk viscosity can be strongly affect-ed by nanomaterials. The present work demonstrates the potential of this microrheology tech-nique as an accurate tool to explore biological soft matter dynamics.

Related References
J.-F. Berret, Local viscoelasticity of living cells measured by rotational magnetic spectroscopy, Nat. Commun., 7 (2016) 10134
F. Mousseau et al., Supported pulmonary surfactant bilayers on silica nanoparticles: formulation, stability and impact on lung epithelial cells, Nanoscale, 9 (2017) 14967-14978.
F. Mousseau and J.F. Berret, The role of surface charge in the interaction of nanoparticles with model pulmo-nary surfactants, Soft Matter, 14 (2018) 5764-5774.
C. Puisney et al., Brake wear (nano)particle characterization and toxicity on airway epithelial cells in vitro, Environmental Science-Nano, 5 (2018) 1036-1044.
M. Falahati et al., A health concern regarding the protein corona, aggregation and disaggregation, Biochimica and Biophysica Acta - General Subjects 1863 (2019) 971–991
L.P.A. Thai et al., On the rheology of pulmonary surfactant: Effects of concentration and consequences for the surfactant replacement therapy, Colloids and Surfaces B: Biointerfaces, 178 (2019) 337-345.


Prof. Amy Shen

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