[Seminar] 'A Journey with Semipinacol Rearrangement: From a Serendipitous Observation to Systematic Study' Prof. Yong-Qiang Tu

Title: A Journey with Semipinacol Rearrangement: From a Serendipitous Observation to Systematic Study

Speaker: Prof. Yong-Qiang Tu
                    Lanzhou University； Shanghai Jiao Tong University, P. R. China

Astract:
One of the important key points during my career is the serendipitous observation of an interesting reductive rearrangement reaction of α–hydroxy epoxides in 1995. Inspired by such a tandem reaction, we started a wonderful journey in the research field of semipinacol rearrangement related organic synthesis. After 20 years assiduous efforts, we have brought this old topic with some new contents,¹ which ranges from a series of tandem reaction modes to their application in total synthesis of bioactive molecules and asymmetric catalysis. In this lecture, a systematic introduction of our research related to the semipinacol rearrangement will be presented. We hope you will draw some inspiration and reference from it.

Reference:
[1] For selected recent reivews, see: (a) Snape T. J. Recent advances in the semi-pinacol rearrangement of α-hydroxyepoxides and related compounds, Chem. Soc. Rev., 2007, 36: 1823; (b) Wang B.-M., Tu Y.-Q. Stereoselective construction of quaternary carbon stereocenters via a semipinacol rearrangement strategy, Acc. Chem. Res., 2011, 44: 1207; (c) Song Z.-L., Fan C.-A., Tu Y.-Q. Chem. Rev., 2011, 111: 7523; (d) Wang S.-H., Li B.-S., Tu Y.-Q. Catalytic asymmetric semipinacol rearrangement, Chem. Commun., 2014, 50: 2393.

Host: Prof. Fujie Tanaka