Seminar 'Diversity Generation in Immune Receptor Repertoires' by Prof. Aleksandra Walczak, Mon 27th July 14:00-15:00
Biological Physics Theory Unit would like to invite you to a seminar by Prof. Aleksandra Walczak on Monday, 27th July.
Date/Time: Monday 27 July 2015 at 14:00-15:00
Venue: Seminar Room C209, Level/Floor C, Centre Bldg.
Speaker: Prof. Aleksandra Walczak, Département de Physique, École Normale Supérieure, France
Title: Diversity Generation in Immune Receptor Repertoires
Recognition of pathogens relies on the diversity of immune receptor proteins. Recent experiments that sequence the entire immune cell repertoires provide a new opportunity for quantitative insight into naturally occurring diversity and how it is generated. I will describe how we can use statistical inference to quantify the origins of diversity in these sequence and characterize selection in the somatic evolutionary process that leads to the observed receptor diversity. A well-adapted repertoire should be tuned to the pathogenic environment to reduce the cost of infections. I will finish by discussing the form of the optimal repertoire that minimizes the cost of infections contracted from a given distribution of pathogens.
We look forward to seeing you at the seminar.
HR Management Section・Biological Physics Theory Unit
Okinawa Institute of Science and Technology Graduate University
1919-1 Tancha, Onna-son, Okinawa 904-0495 JAPAN
Tel: +81-98-966-2116 (Direct) +81-98-966-8711 (Main)
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