Seminar 'Diversity Generation in Immune Receptor Repertoires' by Prof. Aleksandra Walczak, Mon 27th July 14:00-15:00

Dear all,

Biological Physics Theory Unit would like to invite you to a seminar by Prof. Aleksandra Walczak on Monday, 27^th July. 

Date/Time:   Monday 27 July 2015 at 14:00-15:00
Venue:          Seminar Room C209, Level/Floor C, Centre Bldg.
Speaker:       Prof. Aleksandra Walczak, Département de Physique, École Normale Supérieure, France

Title:             Diversity Generation in Immune Receptor Repertoires

Abstract:

Recognition of pathogens relies on the diversity of immune receptor proteins. Recent experiments that sequence the entire immune cell repertoires provide a new opportunity for quantitative insight into naturally occurring diversity and how it is generated. I will describe how we can use statistical inference to quantify the origins of diversity in these sequence and characterize selection in the somatic evolutionary process that leads to the observed receptor diversity. A well-adapted repertoire should be tuned to the pathogenic environment to reduce the cost of infections. I will finish by discussing the form of the optimal repertoire that minimizes the cost of infections contracted from a given distribution of pathogens.
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We look forward to seeing you at the seminar.

Best regards,
Momoko Zamami
 
HR Management Section・Biological Physics Theory Unit 
Okinawa Institute of Science and Technology Graduate University 
1919-1 Tancha, Onna-son, Okinawa 904-0495 JAPAN 
Tel: +81-98-966-2116 (Direct) +81-98-966-8711 (Main)  
E-mail: momoko.zamami@oist.jp 
http: //www.oist.jp