Synthesis of Novel Pharmaceutical Synthons (Spirooxindoles) (No. 0023)

 
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Summary

Spirooxindoles having potential pharmaceutical applications.

The global drug discovery market size is anticipated to reach USD 110 billion by 2025, expanding at a CAGR of 9.6% over the forecast period. Spirooxindole, a unique and versatile scaffold, has been widely studied in some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the application of medicine, quite a few compounds featuring spirooxindole motif have displayed excellent and broad pharmacological activities. Many identified candidate molecules have been used in clinical trials, showing promising prospects. However, previously known synthesis methods are very time consuming and involve complicated pathways. Here, we present a promising spirooxindole synthesis method developed by a group of researchers led by Prof. Fujie Tanaka. The developed technology overcomes the above problems and provides a method to concisely and stereoselectively synthesize novel spirooxindole derivatives from easily accessible starting materials under mild conditions (low temperature).

 

Lead Researcher:
Fujie Tanaka

Faculty of Chemistry and Chemical Bioengineering Unit

Applications

  • Pharmaceutical Compound Synthons
  • Diagnostic Compounds
  • Probe Molecules For Investigating Bio-Functions

 

Advantages

  • Synthesis of novel spirooxindole derviatives at low temperature
  • Asymmetric synthesis of spirooxindole derivatives
  • Transformation of synthesized sirooxindole derivatives into new products

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Technology's Essence

Essentially, Prof. Tanaka has developed a novel chemically and biologically important spirooxindole synthesis method. Specifically, a method is provided to concisely and stereoselectively synthesize novel spirooxindole derivatives from easily accessible starting materials under mild conditions (low temperature).

 

Media Coverage and Presentations

 

CONTACT FOR MORE INFORMATION

  Graham Garner
Technology Licensing Section

  tls@oist.jp
  +81(0)98-966-8937