Publications

Shindou, T., Shindou, M., Watanabe, S., Wickens, J.R. "A silent eligibility trace enables dopamine dependent synaptic plasticity for reinforcement learning in the mouse striatum" European Journal of Neuroscience (In Press).

Zucca, S, Zucca, A, Nakano, T, Aoki, S., Wickens, J.R. 2018, Pauses in cholinergic interneuron firing exert an inhibitory control on striatal output in vivo” eLife (in press)

Aoki, S, Liu, AW, Akamine, Y, Zucca,  A, Zucca, S, Wickens, J.R., (2018), "Cholinergic interneurons in the rat striatum modulate substitution of habits", European Journal of Neuroscience. pp. 1-12, 2018. doi:10.1111/ejn.13820.

Aoki S, Liu AW, Zucca A, Zucca S, Wickens JR., 2017, New variations in strategy set-shifting in the rat. Journal of Visualized Experiments (119) e55005.

​Liu, A.W., Aoki, S., Wickens, J.R., 2017, "A Streamlined Method for the Preparation of Gelatin Embedded Brains and Simplified Organization of Sections for Serial Reconstructions".  bio-protocol. Vol 7, Iss 22, Nov 20, 2017. DOI: 10.21769/bioProtoc.2610

Aoki, S., Liu, A.W., Zucca, A., Zucca, S., Wickens, J.R. (2016) "New variations for strategy set-shifting in the rat." JoVE (Journal of visualized Experiments).

Nakano, T., Mackay, S.M., Wui, T-E., Dani, K.M., Wickens, J.R., 2016, Interfacing with neural activity via femtosecond laser stimulation of drug-encapsulating liposomal nanostructures. eNeuro: Volume 3, Issue 6.

Nagai, T., Nakamuta, S., Kuroda, K., Nakauchi, S., Nishioka, T., Takano, T., Zhang, X-J., Tsuboi, D., Funahashi, Y., Nakano, T., Yoshimoto, J., Kobayashi, K., Uchigashima, M., Watanabe, M., Miura, M., Nishi, Al, Kobayashi, K., Yamada, K., Amano, M., Kibuchi, K. (2016). "Phosphoproteomics of the dopamine pathway enables discovery of Rap1 activation as a reward signal in vivo. Neuron 89(3): 550-565.

Nakano, T., Otsuka, M., Yoshimoto, J., Doya, K. (2015). "A spiking neural network model of model-free reinforcement learning with high-dimensional sensory input and perceptual ambiguity." PLoS One 10(3): e0115620.

Aoki S, Liu AW, Zucca A, Zucca S, Wickens JR., 2015. Role of striatal cholinergic interneurons in set-shifting in the rat. Journal of Neuroscience. 24; 35:9424-31.

Perk, C.G., Wickens, J.R., Hyland, B.I., 2015. Differing properties of putative fast-spiking interneurons in the striatum of two rat strains. Neuroscience 294:215-26.

Nakano, T., Chin, C., Myint, D.M.A., Tan, E.W., Hale, P.J., M., K.M.B., Reynolds, J.N.J., Wickens, J., Dani, K.M., 2014. Mimicking subsecond neurotransmitter dynamics with femtosecond laser stimulated nanosystems. Scientific Reports 4, 1-6.

Furukawa, E., Bado, P., Tripp, G., Mattos, P., Wickens, J.R., Bramati, I.E., Alsop, B., Ferreira, F.M., Lima, D., Tovar-Moll, F., Sergeant, J.A., Moll, J., 2014. Abnormal striatal BOLD responses to reward anticipation and reward delivery in ADHD. PLoS One 9, e89129.

Aquili, L., Liu, A.W., Shindou, M., Shindou, T., Wickens, J.R., 2014. Behavioral flexibility is increased by optogenetic inhibition of neurons in the nucleus accumbens shell during specific time segments. Learning & Memory 21, 223-231.

Oorschot, D.E., Lin, N., Cooper, B.H., Reynolds, J.N., Sun, H., Wickens, J.R., 2013. Synaptic connectivity between rat striatal spiny projection neurons in vivo: Unexpected multiple somatic innervation in the context of overall sparse somatic connectivity. Basal Ganglia 3, 93-108

Li, Y.-T., Wickens, J.R., Huang, Y.-L., Pan, W.H.T., Chen, F.-Y.B., Chen, J.-J.J., 2013. Integrated wireless fast-scan cyclic voltammetry recording and electrical stimulation for reward-predictive learning in awake, freely moving rats. Journal of Neural Engineering 10, 04600

Ponzi, A., Wickens, J.R., 2013. Input dependent variability in a model of the striatal medium spiny neuron network, in: Yamaguchi, Y.E. (Ed.), Advances in Cognitive Neurodynamics (III). Springer, pp. 139-145.

Ponzi, A., & Wickens, J. R. (2013). The inhibitory network of the striatum at the edge of chaos. BMC Neuroscience, 14(Suppl 1), O19. http://doi.org/10.1186/1471-2202-14-S1-O19

Ponzi A, Wickens JR (2013) Optimal Balance of the Striatal Medium Spiny Neuron Network. PLoS Comput Biol 9(4): e1002954. doi:10.1371/ journal.pcbi.1002954 

Tripp, G. and J. R. Wickens (2012). "Reinforcement, dopamine and rodent models in drug development for ADHD." Neurotherapeutics 9(3): 622-634.

Aggarwal, M., Hyland, B.I. and Wickens, J.R. (2012) Neural control of dopamine release: implications for reinforcement learning. European Journal of Neuroscience 35: 1115-1123.

Ponzi, A., and Wickens, J.R. (2012) Input dependent cell assembly dynamics in a model of the striatal medium spiny neuron network. Frontiers in Systems Neuroscience 6: 1-14.

Aggarwal, M. and Wickens, J.R. (2011) A role for phasic dopamine neuron firing in habit learning. [Preview] Neuron, 72, 892-894 

Shindou, T., Ochi-Shindou, M. and Wickens, J.R. (2011) A Ca2+ threshold for induction of spike-timing dependent depression in the mouse striatum. Journal of Neuroscience 31: 13015-22.  

Schulz, J.M., Pitcher, T.L., Savanthrapadian, S. Wickens, J.R., Oswald, M.J. and Reynolds, J.R. (2011) In vivo membrane potential and spike dynamics in projection neurons and interneurons of the striatum show distinct frequency-dependence. Journal of Physiology 589: 4365-81.

Dejean, C., Arbuthnott, G., Wickens, J. R., Le Moine, C., Boraud, T. and Hyland, B. I. (2011) Power fluctuations in beta and gamma frequencies in rat globus pallidus: association with specific phases of slow oscillations and differential modulation by dopamine D1 and D2 receptors. Journal of Neuroscience 31: 6098-6107. 

Wickens, J.R., Hyland, B.I. and Tripp, G. (2011) Animal models to guide clinical drug development in ADHD: Lost in translation? British Journal of Pharmacology 164: 1107–1128. 

Ponzi, A., and Wickens, J.R. (2010) Sequentially switching cell assemblies in random inhibitory networks of spiking neurons in the striatum. Journal of Neuroscience, 30, 5894-5911. 

Pawlak, V., Wickens, J.R., Kirkwood, A., and Kerr, J.N. (2010) Timing is not everything: Neuromodulation opens the STDP gate. Frontiers in Synaptic Neuroscience 2, 146.

Schulz, J.M., Redgrave, P., Mehring, C., Aertsen, A., Clements, K.M., Wickens, J.R., and Reynolds, J.N. (2009). Short-latency activation of striatal spiny neurons via subcortical visual pathways. Journal of Neuroscience 29, 6336-6347. 

Tripp, G. and Wickens, J.R., Neurobiology of ADHD. Neuropharmacology 57, 579-589 (2009). 

Sutherland, K.R., Alsop, B., McNaughton, N., Hyland, B.I., Tripp, G., and Wickens, J.R. (2009) Sensitivity to delay of reinforcement in two animal models of attention deficit hyperactivity disorder (ADHD). Behavioral Brain Research 205, 372-376. 

Johansen, E.B., Killeen, P.R., Russell, V.A., Tripp, G., Wickens, J.R., Tannock, R., Williams, J. and Sagvolden, T. (2009) Origins of altered reinforcement effects in ADHD. Behavior and Brain Function 5: 7. 

Voon, V., Fernagut, P.O., Wickens, J., Baunez, C., Rodriguez, M., Pavon, N., Juncos, J.L., Obeso, J.A. and Bezard, E. (2009) Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders. Lancet Neurology 8:1140-1149. 

Ponzi, A. and Wickens, J. (2009) Cell assemblies in large sparse biologically realistic networks of spiking neurons. Advances in Neural Information Processing 21:1273-1281.

Joshua, M, Adler, A.,  Prut, Y, Vaadia, E., Wickens, J.R. and Bergman, H. (2009) Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events. Neuron, 62: 695-704.

Wickens, J.R. (2009) Synaptic plasticity in the basal ganglia. [Invited Review] Behavioural Brain Research 199: 119-128. 

Wickens, J.R. (2008) Toward an anatomy of disappointment: reward-related signals from the globus pallidus. [Invited Preview] Neuron 60, 530-1. 

Pan, W. X., Schmidt, R., Wickens, J. R. and Hyland, B. I. (2008) Tripartite mechanism of extinction suggested by dopamine neuron activity and temporal difference model. Journal of Neuroscience 28, 9619-31. 

Shindou, T., Arbuthnott, G.W. and Wickens, J.R. (2008) Actions of adenosine A2A receptors on synaptic connections of spiny projection neurons in the neostriatal inhibitory network. Journal of Neurophysiology 99, 1884-9. 

Tripp, G. and Wickens, J.R.  (2008) Dopamine transfer deficit: A neurobiological hypothesis of altered reinforcement mechanisms in ADHD. Journal of Child Psychology and Psychiatry 49, 691-704.

Pitcher, T.L., Wickens, J.R., and Reynolds, J.N.J. (2007) Differences in striatal action potentials between two behaviorally distinct rat strains. Neuroscience 146, 135-142. 

Wickens, J.R., Arbuthnott, G.W., Shindou, T. (2007) Simulation of GABA function in the basal ganglia: Computational models of GABAergic mechanisms in basal ganglia function. Progress in Brain Research 160, 313-329. 

Wickens, J.R., Horvitz, J.C., Costa, R.M., Killcross, S. (2007) Dopaminergic mechanisms in actions and habits. Journal of Neuroscience 27, 8181-3. 

Wickens, J.R., Budd, C.S., Hyland, B.I., and Arbuthnott, G.W. (2007) Striatal contributions to reward and decision-making: making sense of regional variations in a reiterated processing matrix. Annals of the New York Academy of Sciences, USA 1104, 192-212. 

Arbuthnott, G.W., and Wickens, J.R. Space, time and dopamine. Trends in Neuroscience 30, 62 - 69 (2007)

Pan, W-X., Schmidt, R., Wickens, J.R. and Hyland, B.I. Dopamine cells respond to predicted events during classical conditioning: evidence for eligibility traces in the reward-learning network. Journal of Neuroscience 25, 6235-6242 (2005)

Jordan, K., Hyland, B.I., Wickens, J.R. and Anson, J.G. Motor preparation in a memorised delay task. Experimental Brain Research 166, 102-108 (2005)

Reynolds, J.N.J., Hyland, B.I. and Wickens, J.R. Modulation of an afterhyperpolarisation by the substantia nigra  induces pauses in the tonic firing of striatal cholinergic interneurons. Journal of Neuroscience 24, 9870-9877 (2004)

Gurney, K., Prescott, T.J., Wickens, J.R. and Redgrave, P. Computational models of the basal ganglia: from membranes to robots. Trends in Neurosciences 27, 453-9 (2004).

Reynolds, J.N.J. and Wickens, J.R. The corticostriatal input to giant aspiny interneurons in the rat: a candidate pathway for synchronising the response to  reward-related cues. Brain Research, 1011, 115-128 (2004).

Wickens, J.R., Booker, C. McFarlane, J. and McNaughton, N. Dissociation of hypertension and fixed interval responding in two separate strains of genetically hypertensive rat. Behavioural Brain Research 152, 393-401 (2004).

Wickens, J.R., Reynolds, J.N.J. and Hyland, B.I. Neural mechanisms of reward-related motor learning, Current Opinion in Neurobiology 13, 685-90 (2003) [Invited article].

Reynolds, J.N.J. and Wickens, J.R. A state-dependent trigger for electrophysiological recording at predetermined membrane potentials. Journal of Neuroscience Methods,13, 111-119 (2003).

McNaughton, N. and Wickens, J.R. Hebb, pandemonium and catastrophic hypermnesia: the hippocampus as a suppressor of inappropriate associations. Cortex, 39, 1139-1163 (2003).

Tunstall, M.J., Oorschot, D.E., Kean, A.J. & Wickens, J.R. Inhibitory interactions between spiny projection neurons in the rat striatum. Journal of Neurophysiology 88: 1263-1269 (2002).

Reynolds, J.N.J. and Wickens, J.R. Dopamine-dependent plasticity of corticostriatal synapses. Neural Networks 15: 507-521 (2002).

Kerr, J.N.D. and Wickens, J.R. Dopamine D-1/D-5 receptor activation is required for long-term potentiation in the rat neostriatum, in-vitro. Journal of Neurophysiology  85, 117-124 (2001)

Reynolds, J., Hyland, B.I. and Wickens, J.R. A cellular mechanism of reward-related learning. Nature 413, 67-70 (2001).

Anson, J.G., Hyland, B.I., Kotter, R. and Wickens, J.R. Parameter precuing and motor preparation. Motor Control 4, 221-231 (2000).

Arbuthnott, G.W., Ingham, C.A. and Wickens J.R. Dopamine and synaptic plasticity in the neostriatum. Journal of Anatomy 196, 587-596 (2000).

Reynolds, J. and Wickens, J.R. Substantia nigra dopamine regulates synaptic plasticity and membrane potential fluctuations in the rat neostriatum, in vivo. Neuroscience 99, 199-203 (2000).

Arbuthnott, G.W., Ingham, CA. and Wickens, J.R. Modulation by dopamine of rat corticostriatal input. Advances in Pharmacology 42, 733-736 (1998).

Kötter, R. and Wickens, J.R. Striatal mechanisms in Parkinson's disease: New insights from computer modelling. Artificial Intelligence in Medicine 13, 37-55 (1998).

Wickens, J.R. and Wilson, C.J. Regulation of action potential firing in spiny neurons of the rat neostriatum in vivo. Journal of Neurophysiology 79, 2358-2364 (1998).

Wickens, J.R., Mckenzie, D., Costanzo, E. and Arbuthnott, G.W. Effects of potassium channel blockers on synaptic plasticity in the corticostriatal pathway. Neuropharmacology 37, 523-533 (1998).

Mohagheghi, A.A., Anson, J.G., Hyland, B.I., Parr-Brownlie, L. and Wickens, J.R. Foreperiod length, but not memory, affects human reaction time in a precued delayed response. Motor Control 2, 133-141 (1998).

Parr-Brownlie, L., Wickens, J.R., Anson, J.G. and Hyland, B.I. Does having to remember the position of a target improve reaction time? Motor Control 2, 142-147 (1998).

Wickens, J.R. and Miller, R. A formalisation of the neural assembly concept 1. Constraints on neural assembly size. Biological Cybernetics 77, 351-358 (1997).

Wickens, J.R. Basal ganglia: Structure and computations. Network, Computation in Neural Systems 8, 77-109 (1997).

Wickens, J.R., Begg, A.J. and Arbuthnott, G.W. Dopamine reverses the depression of rat cortico-striatal synapses which normally follows high frequency stimulation of cortex in vitro. Neuroscience 70, 1-5 (1996).

Wickens, J.R., Kötter, R. and Alexander, M.E. Effects of local connectivity on striatal function: Simulation and analysis of a model. Synapse 20, 281-298 (1995).

Kötter, R. and Wickens, J.R.  Interactions of glutamate and dopamine in a computational model of the striatum: Relevance to Parkinson's disease. Journal of Computational Neuroscience 2, 195-214 (1995).

Wickens, J.R., Hyland, B. and Anson, G. Cortical cell assemblies: A possible mechanism for motor programs. Journal of Motor Behaviour 26, 66-82 (1994).

Wickens, J.R.  Corticostriatal interactions in neuromotor programming. Human Movement Science 12, 17-35 (1993).

Wickens, J.R. and Arbuthnott, G.W.  The  corticostriatal system on computer simulation: An intermediate mechanism for sequencing of actions. Progress in Brain Research 99, 325-339 (1993).

Alexander, M.E. and Wickens, J.R.  Analysis of striatal dynamics: The existence of two modes of behaviour. Journal of Theoretical Biology 163, 413-438 (1993).

Wickens, J.R., Alexander, M.E. and Miller, R. Two dynamic modes of striatal function under dopaminergic-cholinergic control:  simulation and analysis of a model. Synapse 8, 1-12  (1991).

Abraham, W.C. and Wickens, J.R. Heterosynaptic long-term depression is facilitated by blockade of inhibition in area CA1 of the hippocampus. Brain Research 546, 336-340 (1991).

Wickens, J. and Abraham, W.C. The involvement of L-type calcium channels in heterosynaptic long-term depression in the hippocampus. Neuroscience Letters 130, 128-132 (1991).

Miller, R. and Wickens, J.R. Corticostriatal cell assemblies in selective attention and in representation of predictable and controllable events. Concepts in Neuroscience 2, 65-95 (1991).

Wickens, J.R. Striatal dopamine in motor activation and reward-mediated learning. Steps towards a unifying model. Journal of Neural Transmission 80, 9-31 (1990).

Miller, R., Wickens, J.R. and Beninger, R. Dopamine D-1 and D-2 receptors in relation to reward and performance: a case for the D-1 receptor as a primary site of therapeutic action of neuroleptic drugs. Progress in Neurobiology  34, 143-183 (1990).

Wickens, J.R. Electrically coupled but chemically isolated  synapses: dendritic spines and calcium in a rule for synaptic  modification. Progress in Neurobiology  31, 507-528 (1988).

Book chapters

Wickens, J. R., Arbuthnott, G. W., 2010. Gating of cortical input to the striatum. In: Steiner, H., Tseng, K. Y., (Eds), Handbook of Basal Ganglia Structure and Function. AP. ISBN 978-0-12-374767-9 pp341-352

Plenz, D., Wickens, J. R., 2010. The striatal skeleton: Medium spiny projection neurons and their lateral connections. In: Steiner, H., Tseng, K. Y., (Eds), Handbook of Basal Ganglia Structure and Function. AP. In Press ISBN 978-0-12-374767-9 pp99-112

Shindou, T. and Wickens, J. (2009) Drugs for Motor Disorders, in Encyclopedia of Neuroscience, Vol. 4,  Marc D. Binder, Nobutaka Hirokawa, Uwe Windhorst (Eds) Springer, DOI 10.1007/978-3-540-29678-2_1625.

Shindou, T., Arbuthnott, G.W. and Wickens, J.R. Neuromodulation and neurodynamics of striatal inhibitory networks: implications for Parkinson's disease. In Cortico-subcortical dynamics in Parkinson’s Disease. Editor: Kuei Y. Tseng. Humana Press & Springer Editorials. 2009, In Press.

Bolam, J.P,. Bergman, H., Graybiel, A., Kimura, M., Plenz, D.,Seung, H.S., Surmeier, D.J. and Wickens, J.R. Molecules, microcircuits and motivated behaviour: Microcircuits in the striatum; in: S. Grillner and A.M. Graybiel (eds) Microcircuits: the interface between neurons and global brain function. Dahlem Workshop Report 93. The MIT Press, Cambridge, MA: 2006, p 165-190.

Bergman, H., Kimura, M. and Wickens, J.R. Modulation of striatal circuits by dopamine and acetylcholine; in:  S. Grillner and A.M. Graybiel (eds) Microcircuits: the interface between neurons and global brain function. Dahlem Workshop Report 93. The MIT Press, Cambridge, MA: 2006, p 149-164.

Wickens, J. R. Hyland, B. I., and Tripp, G. Frontostriatal mechanisms in reinforcement: implications for ADHD. in Recent breakthroughs in basal ganglia research. Ed. E. Bezard, Nova Science Publishers, Inc., NY. 2006 pp 65-80.

Wickens, J.R. and Arbuthnott, G.W. Structural and functional interactions in the striatum at the receptor level, in Dunnett, Bentivoglio, Björklund & Hökfelt (eds) Handbook of Chemical Neuroanatomy, Volume 21, Chapter 5, pp 199-236 (2004).

Reynolds, J.N.J. and Wickens, J.R. Self-stimulation and synaptic plasticity, in The Basal Ganglia VII, L. Nicholson, and R.L.M. Faull, eds, New York, Plenum Press (2002), 299-312 [ISBN 0-306-47284-8].

Oorschot, D.E., Tunstall, M.J. and Wickens, J.R. Local connectivity between striatal spiny projection neurons: A re-evaluation, in The Basal Ganglia VII, L. Nicholson and R.L.M. Faull, eds, New York, Plenum Press (2002), pp 421-434 [ISBN 0-306-47284-8].

Wickens, J.R. Surround inhibition in the basal ganglia, in: The Basal Ganglia VI, A.M. Graybiel, M. R. DeLong and S.T. Kitai, eds, Plenum Press, New York (2002) 187-196 [ISBN 0-306-47499-9].

Wickens, J.R. Dopamine regulation of synaptic plasticity in the neostriatum: A cellular model of reinforcement. In: Brain dynamics and the Striatal Complex. R. Miller and J. Wickens, eds,  Harwood Academic, Amsterdam, 65-76 (2000) [ISBN 90-5702-478-0].

Wickens, J.R. and Oorschot, D.E. Neural dynamics and surround inhibition in the neostriatum: A possible connection. In: Brain Dynamics and the Striatal Complex. R. Miller and J. Wickens eds, Harwood Academic, Amsterdam, 141-150 (2000) [ISBN 90-5702-478-0].

Plenz, D., Wickens, J.R. and Kitai, S.T. Basal ganglia control of sequential activity in cerebral cortex: A model. In Computational Neuroscience. J.M. Bower, ed., Academic Press, San Diego. 397-402 (1996) [ISBN 0-7923-9543-3].

Kötter, R. and Wickens, J.R. Effects of an excitatory synaptic conductance and a slow membrane potassium conductance in an inhibitory striatal network model. In: Supercomputing in Brain Research: From Tomography to Neural Network, H.J. Herrmann, D.E. Wolf and E. Poppel, eds, World Scientific, Singapore. 257-263 (1995).

Wickens, J.R. and Kötter, R. Cellular models of reinforcement. In: Models of Information Processing in the Basal Ganglia. J. C. Houk, J. L. Davis and D. G. Beiser, eds, M.I.T. Press. Boson. 187-214 (1995) [ISBN 0-262-08234-9]

Borisyuk, R.M., Wickens, J.R. and Kötter, R. Reinforcement learning in a network model of the basal ganglia. In: Cybernetics and Systems, R. Trappl, ed., Singapore, World Scientific Press  1681-1686 (1994).

Kötter, R., Alexander, M.E. and Wickens, J.R. Effects of asymmetric neuronal connectivity and dopamine on striatal function: Simulation and analysis of a model for Huntington's disease. In: The Neurobiology of Computation. J.M. Bower, ed., Kluwer, 239-244 (1994) [ISBN 0-7923-9543-3].

Wickens, J.R. The contribution of the striatum to cortical function. In: Information Processing in the Cortex. A. Aertsen and V. Braitenberg eds., Berlin, Springer. 271-284 (1992) [ISBN 3-540-55391-6].

 

Books

Miller, R. and Wickens, J.R. (eds) Brain Dynamics and the Striatal Complex, in the series Conceptual Advances in Brain Research, Harwood Academic, Amsterdam (2000) 311pp [ISBN 90-5702-478-0] 

Wickens, J.R. A Theory of the Striatum. Oxford, Pergamon Press (1993) 182pp [ISBN 0-08-042278-0].