Publications
Peer-reviewed Publications
Jo J, Yang L, Tran HD, You WJ, Sun AX, Chang YY, Jung BC, Lee SJ, Saw TY, Xiao B, Khoo ATT, Yaw LP, Xie J, Lokman H, Ong WY, Lim GGY, Lim KL, Tan EK, Ng HH, Je HS. Lewy-body like inclusions in human midbrain organoid carrying glucocerebrosidase and alpha synuclein mutations. Annals of Neurology (JCR Impact Factor: 10.422), July 20, 2021, Accepted.
Kwak TH, Kang JH, Hali S, Kim J, Kim KP, Park C, Lee JH, Ryu HK, Jo J, Je HS, Ng HH, Kwon J, Kim NH, Hong KH, Sun W, Chung CH, Rhyu IJ, Han DW. Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson’s disease modeling. Stem Cells (JCR Impact Factor: 6.277), February 21, 2020;38(6):727-40.
Hong S*, Jo J*, Kim HJ, Lee JE, Shin DH, Lee SG, Baek A, SH Shim, Lee DR. RuvB-like protein 2 (Ruvbl2) has a role in directing the neuroectodermal differentiation of mouse embryonic stem cells. Stem Cells and Development (JCR Impact Factor: 3.272), September 15, 2016; 25(18):1376-85 (*co-first author).
Jo J, Xiao Y, Sun AX, Cukuroglu E, Tran HD, Göke J, Tan ZY, Saw TY, Tan CP, Lokman H, Lee Y, Kim D, Ko HS, Kim SO, Park JH, Cho NJ, Hyde TM, Kleinman JE, Shin JH, Weinberger DR, Tan EK, Je HS, Ng HH. Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin–producing neurons. Cell Stem Cell (JCR Impact Factor: 24.633), August 4, 2016; 19(2):248-57 (Previewed in Cell Stem Cell, 145-6).
Yang NJ, Seol DW, Jo J, Jang HM, Yoon SY, Lee WS, and Lee DR. Supplementation with cell-penetrating peptide-conjugated estrogen-related receptor β (CPP-ESRRB) improves the formation of the inner cell mass and the development of vitrified/warmed mouse embryos. Reproductive Sciences (JCR Impact Factor: 3.060), April 12, 2016; 23(11):1509-17.
Jo J, Hwang S, Kim HJ, Hong S, Lee JE, Lee SG, Baek A, Han H, Lee JI, Lee I, Lee DR. An integrated systems biology approach identifies positive cofactor 4 as a factor that increases reprogramming efficiency. Nucleic Acids Research (JCR Impact Factor: 16.971), February 18, 2016; 18; 44(3):1203-15.
Yang NJ, Seol DW, Jo J, Jang HM, Yoon SY, and Lee DR. Effect of cell-penetrating peptide-conjugated estrogen related receptor β (CPP-ESRRB) on the development of mouse embryos cultured in vitro. CERM (JCR Impact Factor: 0.620), March 31, 2014; 41(1):1-8.
Jo J, Hong S, Choi WY, Lee DR. Cell-penetrating peptide (CPP)-conjugated proteins is an efficient tool for manipulation of human mesenchymal stromal cells. Scientific Reports (JCR Impact Factor: 4.379), March 14, 2014; 14; 4:4378.
Choi S, Jo J, Seol DW, Cha SK, Lee JE, and Lee DR. Regulation of pluripotency-related genes and differentiation in mouse embryonic stem cells by direct delivery of cell-penetrating peptide-conjugated CARM1 recombinant protein. Dev Reprod, March 31, 2013; 17(1):9-16.
Jo J, Song H, Park SG, Lee SH, Ko JJ, Park JH, Jeong J, Cheon YP and Lee DR. Regulation of differentiation potential of human mesenchymal stem cells by intracytoplasmic delivery of coactivator-associated arginine methyltransferase 1 (CARM1) protein using cell-penetrating peptide (CPP). Stem Cells (JCR Impact Factor: 6.277), June 13, 2012; 30: 1703-1713.
Go YE, Kim HJ, Jo J, Lee HJ, Do JT, Ko JJ, and Lee DR. Comparative analysis for in vitro differentiation potential of induced pluripotent stem cells, embryonic stem cells, and multipotent spermatogonial stem cells into germ-lineage cells. Dev Reprod, March 31, 2011; 15(1): 41-52.
Jo J, Lee Y, Ko JJ, Oh MH, Cheon YP, and Lee DR. Up-regulation of pluripotency-related genes in human amniotic fluid-derived stem cells by ESRRB conjugated with cell-penetrating peptide. Dev Reprod, December 31, 2010; 14(4): 243-251.
Patents
Junghyun Jo, Huck-Hui Ng, Hyunsoo Shawn Je. Generation of midbrain-specific organoids from human pluripotent stem cells. Patent Application (No. 10201601965P), March 14 2016, Singapore / PCT application (No. PCT/SG2017/050126), March 14 2017 (EP17767082.5-1120; US16/085,553; SG10201913687VA; CN-201780029142.2), US20190169576.
Junghyun Jo, Hoang-Dai Tran, Gordon Arbuthnott. Methods and platforms for drug test of synucleinopathy using human brain organoids. In preparation of Provisional Patent Application.