Past Events
OIST Workshop "Principles of Synapse Organization and Neural Network Regulation Gained Through Evolution"
2024年11月5日 (火) (All day) 〜 2024年11月7日 (木) (All day)OIST Workshop | Main organizer: Yukiko Goda (Synapse Biology Unit) | OIST members are welcome to attend all scientific sessions. Meals are closed sessions for registered participants only.
[Seminar] A kinase and a phosphatase: molecular basis of inherited Parkinson’s disease by Prof. Suzanne Pfeffer
2023年6月23日 (金) 10:00 〜 11:00June 23, 2023 10:00 - 11: 00 at C700, Lab 3
Prof. Suzanne Pfeffer, Biochemistry at Stanford University School of Medicine
A kinase and a phosphatase: molecular basis of inherited Parkinson’s disease
Activating mutations in LRRK2 kinase cause Parkinson’s disease and activated LRRK2 phosphorylates a subset of Rab GTPases. We have discovered that Rab phosphorylation blocks primary cilia formation in specific neurons and astrocytes in the nigrostriatal circuit that are important for dopaminergic signaling in Parkinson's disease. This lecture will provide an update on our studies using purified LRRK2 and its counteracting PPM1H phosphatase to understand how the proteins become localized and activated on membrane surfaces. In addition, work will be presented related to the consequences of LRRK2 mutation for neurons and astrocytes in the dorsal striatum of mice and humans.
[Seminar] Transcriptional heterogeneity arising from a signal transduction-transcription factor network by Prof. Mariko Okada, Osaka University
2023年4月24日 (月) 11:00 〜 12:00Transcriptional heterogeneity arising from a signal transduction-transcription factor network
Prof. Mariko Okada
Laboratory for Cell Systems, Institute for Protein Research, Osaka University
[Hybrid Seminar] "Differential glial control of parallel memory formation" by Prof. Ko Matsui, Tohoku University
2022年12月21日 (水) 11:00 〜 12:00"Differential glial control of parallel memory formation" by Prof. Ko Matsui,
Super-network Brain Physiology, Graduate School of Life Sciences, Tohoku University
[Hybrid Seminar] "Improved models for Alzheimer’s disease; plaques, synapses and a protective role for microglia" by Prof. Frances A. Edwards, UCL
2022年9月26日 (月) 16:00 〜 17:00"Improved models for Alzheimer’s disease; plaques, synapses and a protective role for microglia"
by Prof. Frances A. Edwards, Dept Neuroscience Physiology & Pharmacology, University College London