TRAF6 maintains mammary stem cells and promotes pregnancy-induced epithelial cell expansion in mammary gland development

Dear All,

Cell Signal Unit (Yamamoto Unit) would like to inform you of a seminar by Dr. Jun-ichiro Inoue, Institute of Medical Science, The University of Tokyo.

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Date: Wednesday, February 10, 2021

Time: 11:00-12:00

Venue: L4F01 (Lab 4, Level F)

             or

             ZOOM: https://oist.zoom.us/j/92541889235?pwd=akYyNm5qTlJpcXUxcWtUSkl3SGQrZz09

             Meeting ID: 925 4188 9235

             *If you need the passcode, please contact "yuki.nakagawa[at]oist.jp".

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Speaker:

Dr. Jun-ichiro Inoue, Institute of Medical Science, The University of Tokyo

Title:

TRAF6 maintains mammary stem cells and promotes pregnancy-induced epithelial cell expansion in mammary gland development

Abstract:
RANK signaling promotes pregnancy-dependent epithelial cell differentiation and expansion for mammary gland development, which requires NF-kB pathway-dependent Cyclin D1 induction and Id2 pathway-dependent anti-apoptotic gene induction. However, the roles of tumor necrosis factor receptor-associated factor 6 (TRAF6) remain unclear despite its requirement in RANK signaling. We have recently demonstrated that TRAF6 is crucial for both mammary stem cell maintenance and pregnancy-induced epithelial cell expansion. TRAF6 deficiency impairs PI3K/AKT and canonical NF-kB pathways, whereas noncanonical NF-kB signaling remains functional. Therefore, we propose that TRAF6 promotes cell proliferation by activating PI3K/AKT signaling to induce RB phosphorylation in concert with noncanonical NF-kB pathway-dependent Cyclin D1 induction. Furthermore, TRAF6 inhibits apoptosis by activating canonical NF-kB signaling to induce anti-apoptotic genes with the Id2 pathway. Therefore, proper orchestration of TRAF6-dependent and -independent RANK signals likely establishes mammary gland formation

Host:
Prof. Tadashi Yamamoto

We hope to see many of you at the seminar.

Best regards,

Yuki Nakagawa

Research Unit Administrator

Cell Signal Unit