High throughput screening systems for inhibitors of phosphorylation dependent signaling molecules using fluorescent proteins

Dear All,

Cell Signal Unit (Yamamoto Unit) would like to inform you of a seminar by Dr. Nobumoto Watanabe from RIKEN.

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Date: Wednesday, January 29, 2020

Time: 13:00-14:00

Venue: D015, Level D, Lab 1

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Speaker:

Dr. Nobumoto Watanabe, RIKEN

Title:
High throughput screening systems for inhibitors of phosphorylation dependent signaling molecules using fluorescent proteins

Abstract:
Protein phosphorylation is a key event in signal transduction pathways. When upstream signals are stimulated, protein kinases are activated and phosphorylate their substrates, modulating their localization, conformation, and activity. In some cases, phosphorylated substrates become recognizable to other proteins; such interactions transduce and propel the signal onward. Certain domains specifically recognize phosphorylated residues of proteins, regulating cell growth and differentiation. Because the proteins that contain these domains also mediate diseases that are caused by deregulated signal transduction, small molecules that inhibit such motifs are attractive candidates for the treatment of diseases, such as cancer. In this seminar, I will introduce several high-throughput screening systems using fluorescent protein, which were developed in our group to identify small-molecule inhibitors of phosphorylation-dependent signaling. Several examples of small molecule will be presented and the potential uses of this system are discussed.

Host:
Prof. Tadashi Yamamoto

We hope to see many of you at the seminar.

Best regards,

Yuki Nakagawa

Research Unit Administrator

Cell Signal Unit