Hiroshi Watanabe
M.S. (Tokyo Institute of Technology)
B.S. (Tokai University)
Professional Experience
- Tokyo Metropolitan Institute of Medical Science, 2002-2005
- Heidelberg Institute of Zoology, 2005-2009
- Centre for Organismal Studies (COS), University of Heidelberg, 2009-2015
Awards
- Tokai University, Makino Fujio Award, 1997
- TOYOBO Biotechnology Foundation, Post-doctoral Fellowship, 2005-2006
- Alexander von Humboldt Foundation, Post-doctoral Fellowship, 2006-2008
- Top Cited Article Award 2009-2011, Developmental Biology, 2011
Publications
Hongo, Y., Fukuyama, D., Chen, LC., Sekimoto, K., Watanabe, H. Ghost peaks of aromatic metabolites induced by corona discharge artifacts in LC-ESI-MS/MS. J. Mass Spec. 2024. https://doi.org/10.1002/jms.5102
Mbogo, I., Kawano, C., Nakamura, R., Tsuchiya, Y., Villar-Briones, A., Hirao, Y., Hayakawa, E., Tomii, K., Watanabe, H. A transphyletic study of metazoan β-catenin protein complexes. Zool. Lett. 10, 20, 2024. https://doi.org/10.1186/s40851-024-00243-y
Sheloukhova, L., Watanabe, H. Evolution of glial cells: a non-bilaterian perspective, Neural Dev. 19, 10, 2024. doi: 10.1186/s13064-024-00184-4
Guzman, C., Mohri, K., Nakamura, R., Miyake, M., Tsuchiya, Y., Tomii, K., Watanabe, H. Neuronal and non-neuronal functions of the synaptic cell adhesion molecule neurexin in Nematostella vectensis. Nat. Commun. 15, 6495, 2024. doi: 10.1038/s41467-024-50818-8
Sheloukhova, L., Watanabe, H. Analysis of cnidarian Gcm suggests a neuronal origin of glial EAAT1 function. Sci. Rep. 13, 14790, 2023. doi: 10.1038/s41598-023-42046-9
Nakamura, R., Nakamura, R., Watanabe, H. Cnidarian pharyngeal nervous system illustrates prebilaterian neurosecretory regulation of feeding. BioRxiv 2023. doi: https://doi.org/10.1101/2023.04.05.535675
Mohri, K., Watanabe, H. Neuromuscular organization of the benthic ctenophore, Vallicula multiformis. Zool. Lett. 10, 3, 2023. doi: 10.1186/s40851-024-00225-0
Hayakawa, E., Guzman, C., Horiguchi, O., Kawano, C., Shiraishi, A., Mohri, K., Lin, M. H., Nakamura, R., Nakamura, R., Kawai, E., Komoto, S., Jokura, K., Shiba, K., Shigenobu, S., Satake, H., Inaba, K., & Watanabe, H. Mass spectrometry of short peptides reveals common features of metazoan peptidergic neurons. Nat. Ecol. Evo. 6, 1438–1448, 2022. doi: 10.1038/s41559-022-01835-7
Masuda-Ozawa, T., Fujita, S., Nakamura, R., Watanabe, H., Kuranaga, E., & Nakajima, Y. siRNA-mediated gene knockdown via electroporation in hydrozoan jellyfish embryos. Sci. Rep. 12, 16049, 2022. doi: 10.1038/s41598-022-20476-1
Watanabe H. "Back through time: how cnidarians and basal metazoans shed light on ancient nervous systems." Brain Evolution by Design (Eds.: Shigeo S, Murakami Y, Nomura T) Springer, 2017. Review https://doi.org/10.1007/978-4-431-56469-0_3
Watanabe H**, Kuhn A, Fushiki M, Agata K, Özbek S, Fujisawa T, Holstein TW** “Sequential actions of β-Catenin and Bmp pattern the oral nerve net in Nematostella vectensis.” Nat. Commun. 5, 5536, 2014. **Co-corresponding authors.
Watanabe H**, Schmidt HA, Kuhn A, Höger SK, Kocagöz Y, Laumann-Lipp N, Özbek S, Holstein TW** “Nodal signalling determines biradial asymmetry in Hydra.” Nature 112-115, 515, 2014. **Co-corresponding authors.
Holstein TW, Watanabe H, Özbek S "Signaling pathways and axis formation in the lower metazoa." Curr. Top. Dev. Biol. 137-177, 97, 2011. Review
Watanabe H*, Hongu T*, Yamazaki M, Kanaho Y "Phospholipase D2 activation by p38 MAP kinase is involved in neurite outgrowth." Biochem. Biophys. Res. Commun. 288-293, 413, 2011. *equal authorship.
Suzuki A, Arikawa C, Kuwahara Y, Itoh K, Watanabe M, Watanabe H, Suzuki T, Funakoshi Y, Hasegawa H, Kanaho Y "The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons." FEBS Lett. 2801-2806, 584, 2010.
Chapman JA, Kirkness EF, Simakov O, Hampson SE, Mitros T, Weinmaier T, Rattei T, Balasubramanian PG, Borman J, Busam JD, Disbennett K, Pfannkoch C, Sumin N, Sutton GG, Viswanathan LD, Walenz B, Goodstein DM, Hellsten U, Kawashima T, Prochnik SE, Putnam NH, Shu S, Blumberg B, Dana CE, Gee L, Kibler DF, Law L, Lindgens D, Martinez DE, Peng J, Wigge PA, Bertulat B, Guder C, Nakamura Y, Özbek S, Watanabe H, Khalturin K, Hemmrich G, Franke A, Augustin R, Fraune S, Hayakawa E, Hayakawa S, Hirose M, Hwang JS, Ikeo K, Nishimiya-Fujisawa C, Ogura A, Takahashi T, Steinmetz PR, Zhang X, Aufschnaiter R, Eder MK, Gorny AK, Salvenmoser W, Heimberg AM, Wheeler BM, Peterson KJ, Böttger A, Tischler P, Wolf A, Gojobori T, Remington KA, Strausberg RL, Venter JC, Technau U, Hobmayer B, Bosch TC, Holstein TW, Fujisawa T, Bode HR, David CN, Rokhsar DS, Steele RE “The dynamic genome of Hydra.” Nature 592-596, 464, 2010.
Watanabe H, Hoang VT, Mättner R, Holstein TW “Immortality and the base of multicellular life: Lessons from cnidarian stem cells.” Semin. Cell Dev. Biol. 1114-1125, 20, 2009. Review
Watanabe H, Fujisawa T, Holstein TW “Cnidarians and the evolutionary origin of the nervous system.” Dev. Growth Differ. 167-183, 51, 2009.
Philipp I, Aufschnaiter R, Özbek S, Pontasch S, Jenewein M, Watanabe H, Rentzsch F, Holstein TW, Hobmayer B “Wnt/beta-catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra.” Proc. Natl. Acad. Sci. U. S. A. 4290-4295, 106, 2009.
Lengfeld T*, Watanabe H*, Simakov O, Lindgens D, Gee L, Law L, Schmidt HA, Özbek S, Bode H, Holstein TW “Multiple Wnts are involved in Hydra organizer formation and regeneration.“ Dev. Biol. 186-199, 330, 2009. *equal authorship.
Nishio M, Watanabe K, Sasaki J, Taya C, Takasuga S, Iizuka R, Balla T, Yamazaki M, Watanabe H, Itoh R, Kuroda S, Horie Y, Forster I, Mak TW, Yonekawa H, Penninger JM, Kanaho Y, Suzuki A, Sasaki T "Control of cell polarity and motility by the PtdIns(3,4,5)P(3) phosphatase SHIP1." Nat. Cell Biol. 36-44, 9, 2007.
Guder C, Philipp I, Lengfeld T, Watanabe H, Hobmayer B, Holstein TW "The Wnt code: cnidarians signal the way." Oncogene 7450-7460, 25, 2006 Review
Miyazaki H, Yamazaki M, Watanabe H, Maehama T, Yokozeki T, Kanaho Y "The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation." FEBS Lett. 6834-6838, 579, 2005.
Sasaki J, Sasaki T, Yamazaki M, Matsuoka K, Taya C, Shitara H, Takasuga S, Nishio M, Mizuno K, Wada T, Miyazaki H, Watanabe H, Iizuka R, Kubo S, Murata S, Chiba T, Maehama T, Hamada K, Kishimoto H, Frohman MA, Tanaka K, Penninger JM, Yonekawa H, Suzuki A, Kanaho Y "Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}." J. Exp. Med. 859-870, 201, 2005.
Kanaho Y and Watanabe H. "Measurement of Phospholipase D Activity." Methods for Intracellular Signal Transduction Studies (Ed.: Y. Fukui) Center for Academic Publications Japan, 115-122, Review, Japanese
Watanabe H, Yokozeki T, Yamazaki M, Miyazaki H, Sasaki T, Maehama T, Itoh K, Frohman MA, Kanaho Y “Essential role for phospholipase D2 activation downstream of ERK MAP kinase in NGF-stimulated neurite outgrowth from PC12 cells.” J. Biol. Chem. 37870-37877, 279, 2004.
Watanabe H, Yamazaki M, Miyazaki H, Arikawa C, Itoh K, Sasaki T, Maehama T, Frohman MA, Kanaho Y “Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons.” J. Neurochem. 142-151, 89, 2004.
Nogami M, Yamazaki M, Watanabe H, Okabayashi Y, Kido Y, Kasuga M, Sasaki T, Maehama T, Kanaho Y "Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase C gamma 1 for membrane ruffle formation." FEBS Lett. 71-76, 536, 2003.
Yamazaki M, Miyazaki H, Watanabe H, Sasaki T, Maehama T, Frohman MA, Kanaho Y "Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling." J. Biol. Chem. 17226-17230, 277, 2002.
Watanabe H, Kanaho Y “Inhibition of Phosphatidylinositol 4,5-Bisphosphate-Stimulated Phospholipase D2 Activity by Ser/Thr Phosphorylation.” Biochim. Biophys. Acta –Mol. Cell Res. 121-124, 1495, 2000.
Honda A, Nogami M, Yokozeki T, Yamazaki M, Nakamura H, Watanabe H, Kawamoto K, Nakayama K, Morris AJ, Frohman MA, Kanaho Y "Phosphatidylinositol 4-phosphate 5-kinase a is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation." Cell 521-532, 99, 1999.
Yamazaki M, Zhang Y, Watanabe H, Yokozeki T, Ohno S, Kaibuchi K, Shibata H, Mukai H, Ono Y, Frohman MA, Kanaho Y "Interaction of the Small G Protein RhoA with the C Terminus of Human Phospholipase D1" J. Biol. Chem. 6035-6038, 274, 1999.
Matsuhashi M, Pankrushina AN, Takeuchi S, Ohshima H, Miyoi H, Endoh K, Murayama K, Watanabe H, Endo S, Tobi M, Mano Y, Hyodo M, Kobayashi T, Kaneko T, Otani S, Yoshimura S, Harata A, Sawada T "Production of sound waves by bacterial cells and the response of bacterial cells to sound." J. Gen. Appl. Microbiol. 49-55, 44, 1998.
Matsuhashi M, Takeuchi S, Pankrushina AN, Endoh K, Watanabe H, Endo S, Hiraoka N, Tobi M, Ohshima H, Miyoi H, Murayama K, Yamamura H, Kanoke T, Otani S "From Carbon to Biosonics." Supercarbon (Eds.: Yoshimura S, Chang RPH) 227-233, 33, 1998. Review
Matsuhashi M, Pankrushina AN, Endoh K, Watanabe H "Cellular sonic signals BIOSONICS inducing propagation of neighboring cells." Bioscience and Industry 9-10, 29-31, 55, 1997. Review, Japanese
Matsuhashi M, Shindo A, Endoh K, Watanabe H, Tobi M, Endo S, Ohshima H, Otani S "b-Lactams and other innovative new approaches for controlling bacterial populations." Antibiotic Therapy – Achievements, Problems and Future Perspectives. (Eds.: Busse DW, Zeiler HJ, Labischinski H) Springer Verlag, Berlin, Heidelberg, New York, 17-26, 1997, Review
Matsuhashi M, Endoh K, Pankrushina AN, Watanabe H, Yamamura H, Komiyama M, Endo S, Tobi M, Ohshima H, Mano Y, Hyodo M, Kaneko T, Otani S "Growth-promoting effect of carbon material upon bacterial cells propagating through a distance." J. Gen. Appl. Microbiol. 225-230, 43, 1997.
Matsuhashi M, Pankrushina AN, Endoh K, Watanabe H, Ohshima H, Tobi M, Endo S, Mano Y, Hyodo M, Kaneko T, Otani S, Yoshimura S "Bacillus Carboniphilus cells respond to growth-promoting physical signals from cells of homologous and heterologous bacteria." J. Gen. Appl. Microbiol. 315-323, 42, 1996.
Matsuhashi M, Shindo S, Ohshima H, Tobi M, Endo S, Watanabe H, Endoh K, Pankrushina AN "Cellular signals regulating antibiotic sensitivities of bacteria." Microb. Drug Resist. 91-93, 2, 1996.
Matsuhashi M, Pankrushina AN, Endoh K, Watanabe H, Mano Y, Hyodo M, Fujita T, Kunugita K, Kaneko T, Otani S "Studies on carbon material requirements for bacterial proliferation and spore germination under stress conditions: a new mechanism involving transmission of physical signals." J. Bacteriol. 688-693, 177, 1995.