Seminar "JMJ24 may antagonize IBM1 function for gene regulation" by Dr.Laure Audonnet

Dear All,

Plant Epigenetics Unit (Saze unit) would like to invite you to a seminar by Dr. Laure Audonnet.

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Date: Monday, April 11th, 2016

Time:10:00-11:00

Venue: Seminar Room C016, Lab1

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Speaker: Laure Audonnet, Ph.D, Institute of Plant Biology, Paris-Sud University 

Title: " JMJ24 may antagonize IBM1 function for gene regulation. "

Abstract:

Histone H3 lysine 9 dimethylation (H3K9me2) is a heterochromatic mark linked to DNA methylation and gene repression. Removal of H3K9me2 from gene bodies by the jmjC histone demethylase IBM1/JMJ25 inhibits DNA methylation and derepresses gene expression. In this work, the function of the jmjC gene JMJ24 that are closely related to IBM1/JMJ25 was analyzed. We show that jmj24 mutations produced a number of subtle developmental defects, while affecting only a relatively small number of genes at the vegetative stage. Interestingly, jmj24 mutation could complement plant growth defects and expression changes caused by the ibm1 mutation. Further analysis suggested that JMJ24 might counteract IBM1/JMJ25 for H3K9 demethylation at a few protein coding genes. In addition, we show that JMJ24 may synergistically interact with the RNAi pathways involving siRNAs. The present data suggest that JMJ24 may have a function to counteract IBM1/JMJ25 in gene expression and may cooperate with RNAi pathways for gene silencing.
 

We look forward to seeing many of you at the seminar.

Sincerely,
Yoko Fujitomi
Plant Epigenetics Unit (Saze unit)