Seminar by Prof. Tomohiro Kurosaki. "Cellular and molecular mechanisms for rapid responsiveness of humoral memory responses"

Dear all,

Cell Signal Unit(Yamamoto Unit) would like to invite you to a seminar by Prof. Tomohiro KUROSAKI.

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Date: Friday, May 24th

Time: 16:00 – 17:00

Venue: C016, Lab1

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Speaker: Prof. Tomohiro KUROSAKI

Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University,

Laboratory for Lymphocyte Differentiation, RIKEN RCAI

Title: Cellular and molecular mechanisms for rapid responsiveness of humoral memory responses

Abstract: One striking feature of humoral memory response is quick generation of neutralizing antibodies (Abs) upon re-invasion of pathogenic micro-organisms and eliminating them from our body. However, it is still unclear about cellular and molecular mechanisms underlying such quick humoral responses.

By using model T-dependent antigens, we propose that the following three mechanisms synergistically operate. First, IgG type memory B cells are pre-localized in the place where they can gain easy access to the antigen. Second, Tfh type memory T cells, which reside near to the memory IgG B cells. These memory T cells are promptly activated by antigen-presentation on IgG memory B cells and re-express Bcl6, which in turn activates IgG memory B cells. Finally, IgG memory B cells undergo repression of the Bach2 transcription factor (one of the BCR-extrinsic changes) during primary immune responses, which in turn, contributes to rapid differentiation towards plasma cells.

Host: 

Tadashi Yamamoto, Cell Signal Unit

We look forward to seeing many of you.

Sincerely,

Kaori Yamashiro

Cell Signal Unit (Yamamoto Unit)