Mechanisms and Consequences of Cellular Wound Healing, Keiko Kono

Date

Friday, May 17, 2019 - 16:30 to 17:00

Location

Lab3 C700

Description

Speaker: Keiko Kono, Membranology Unit

Title: Mechanisms and Consequences of Cellular Wound Healing

Abstract: Cellular wounding and repair of local plasma membranes occur constantly in our bodies. Plasma membrane damage can be induced by various triggers ranging from physical disruption and pathogen invasion to physiological cellular activities, such as muscle contraction. Accumulating evidence suggests the involvement of cellular wound healing in various diseases, including Duchenne muscular dystrophy. However, the molecular mechanisms and physiological consequences of plasma membrane repair are poorly understood. Our unit tackles these issues using cell biology, biochemistry and genetics in multiple systems, including yeast and human cultured cells. We previously discovered two key mechanisms: 1) proteasomal degradation triggers repair responses (Kono et al., Cell, 2012), and 2) a cell cycle checkpoint in G1 monitors plasma membrane damage (Kono et al., PNAS, 2016). In this seminar, I will present our unpublished results and discuss its future directions.

All-OIST Category: 

Import this Event: Right-click to download, then open in your calendar application.

Subscribe to the OIST Calendar: Right-click to download, then open in your calendar application.