OIST-UT Joint talk series for future science-Season 4: Nano- and Micro-fabrication Enabled Lab-on-a-chip Platforms for Biotechnology Applications and Beyond


Wednesday, July 14, 2021 - 17:30 to 18:30





Nano- and micro-fabrication enabled lab-on-a-chip platforms for biotechnology applications and beyond


Micro/nanofluidics has emerged as a powerful tool in biotechnology research and for modeling various aspects of biological systems. I will showcase two examples.

・An optomicrofluidic sensing platform is developed to detect antibodies against the SARS-CoV-2 spike protein in diluted human plasma within 30 minutes, at the limit of detection of 0.5 pM. The sensing principle is based on localized surface plasmon resonance involving gold nanospikes in a microfluidic device, coupled with an optical probe. This lab-on-a-chip platform complements existing serological assays for vaccine development and disease diagnostics.

・To model synchronized motions of motile objects (e.g., cilia) translating in biological fluids, we present the first example of viscoelastic fluid-structure interaction in a glass microfluidic device containing free-standing circular cylinders based on a subtractive 3D-printing technique. Our studies demonstrate that slender bodies in viscoelastic flow can exhibit complex highly correlated dynamics, which sheds insight on the analogous processes in biological systems.


Dr. Amy Shen, Professor, Micro/Bio/Nanofluidics Unit, OIST


Amy Shen is a professor in Micro/Bio/Nanofluidics Unit at Okinawa Institute of Science and Technology Graduate University in Japan. Her research is focused on microfluidics and complex fluids at the bio/nano-interface, with applications in biotechnology and various industrial processes. She received the Ralph E. Powe Junior Faculty Enhancement Award in 2003 and the National Science Foundation's CAREER Award in 2007. Amy was a Fulbright Scholar in 2013. She is a Fellow of the Royal Society of Chemistry, and an associate editor for Soft Matter, Micromachines, and Biomedical Microdevices.




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