A303
Course Coordinator:
Ichiro Masai
Developmental Biology
Description:
This course introduces fundamental principles and key concepts in the developmental processes of animal organisms, by focusing on Drosophila embryonic development and vertebrate neural development as models, and will facilitate graduate students to reach a professional level of understanding of developmental biology. Furthermore, genetic tools for live imaging of fluorescence-labeled cells using Drosophila and zebrafish embryos will be introduced as practical exercises. The course also includes debate on specific topics in developmental biology by students and a writing exercise of mock-grant application. Some lecturers outside OIST will be invited to present particular special topics.
Aim:
This lecture series will introduce fundamental principles governing development of animal organisms and current research topics
Course Content:
- Basic concepts of developmental biology, and introduction of model systems
- Development of the Drosophila embryonic body plan
- Organogenesis
- Patterning of vertebrate body plan
- Morphogenesis
- Cell fate decision in the vertebrate nervous system
- Current topics of neuronal specification and multipotency of neural stem cells
- Axon guidance, target recognition
- Synaptogenesis
- A model for neurodegeneration in Drosophila
- Debate of topics of developmental biology by students
- Debate of topics of developmental biology by students
- Debate of topics of developmental biology by students
- Genetic tools for live imaging of fluorescence-labeled cells using Drosophila
- Genetic tools for live imaging of fluorescence-labeled cells using zebrafish
Course Type:
Elective
Credits:
2
Assessment:
Participation 20%; Written Report 40%; Presentation 40%
Text Book:
- Development of the Nervous System 3 edn, Sanes, Reh, Harris (2011) Academic Express
- Developmental Biology 9 edn, Scott F. Gilbert (2010) Sinauer
- Principles of Development 2 edn, Lewis Wolpert (2010) Oxford University Press
Reference Book:
Prior Knowledge:
Notes: