Date
Title:
Translational Supramolecular Chemistry
Abstract:
Supramolecular chemistry is about contacts between molecules. Translational supramolecular chemistry expects that offering new ways to get into contact on the molecular level will provide access to new structures and functions, which ultimately will allow us to tackle otherwise elusive challenges in science and society.
In this spirit, new interactions have been introduced to catalysis: Anion-π interactions in 2013, followed by chalcogen bonds in 2017 and pnictogen bonds in 2018. Several reactions and catalytic systems have been realized by now (foldamers, fullerenes, carbon nanotubes, artificial enzymes, electric fields, lipid bilayer membranes). Emergent properties include the breaking of the Baldwin rules and autocatalytic brevetoxin-like polyether cyclizations in π-acidic surfaces.
The same chalcogen bonds were the key to build mechanosensitive fluorescent probes that change color like lobsters during cooking. The resulting “fluorescent flippers” are the first small-molecule probes that can image physical forces in living cells. Mechanobiological changes in membrane tension can now be imaged throughout, from mitochondrial fission, endocytosis, secretory pathway, nuclear envelope to morphogenesis in early mammalian embryos. Addressing a current need in the life sciences, they had to be commercialized to assure distribution. Flipper probes are thus as an example for the direct translation of demanding supramolecular chemistry principles into products that do well on the market.
The third example for the spirit of translational supramolecular chemistry focuses on dynamic covalent exchange cascades to find new ways to enter into cells. The resulting thiol-mediated uptake emerges as complex network that encodes for cell penetration in the broadest sense, working from genome editing in live animals to general cytosolic delivery into deep tissue, explaining the mystery of FDA-approved antisense oligonucleotide phosphorothioates, affording inhibitors for the cellular entry of pathogens, including SARS-CoV-2 – but how does it really work?
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Andrew Mathas, University of Sydney
Title: Content systems and KLR algebras
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[Neuroscience Club] Dr. Terufumi Fujiwara, Postdoctoral Fellow, Champalimaud Foundation, Portugal. Language: English.
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Target audience: Interns, Students, PostDocs, and those who are interested in the same research field.
Language: English
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Speaker: Yeon Ui Lee, Ph. D
Assistant Professor, Department of Physics, Chungbuk National University, Republic of Korea
JSPS Invitational Fellowships for Research in Japan: 22 July - 20 August 2022
Title: Super Resolution Imaging with Metamaterials
Date
Embodied Rationality through Game Theoretic Glasses: an Empirical Point of Contact.
Sébastien Lerique, Postdoctoral Scholar at the Embodied Cognitive Science Unit.
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Language: English
Date
Seminar by Haruka Osaki, Postdoc at Kyoto University
Date: August 5th
Time: 3pm - (30-40 mins Lecture and 10-20mins QA session)
Zoom: Meeting:
https://us04web.zoom.us/j/
For questions please contact: egu@oist.jp
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[Seminar] Dr. Valentina Basoli "Prospective in cartilage regeneration: development of in vitro osteoarthritis model for testing drugs and sensors"
Date
Title: Are black holes and particles the same thing?
Abstract: I'll discuss the similarities between fundamental particles, thermal systems and black holes. We will play some quantitative games to see exactly how black holes are different from particles in the real world.
Having paid the real world our respects, we will talk about how black holes and fundamental particles *are* the same in string theory - a story rarely covered in popular propaganda, but central to the second superstring revolution. Funny enough, it allows for the "discovery" of new particles through writing down new black hole solutions.
I will then advertise my current work, in which I'm doing exactly that for string theory's wonky cousin, Higher-Spin Gravity.
By Faculty Affairs Office/ Faculty Lunchtime Seminar Coordinators