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Speaker: Dr. Maciej Zgirski, Institute of Physics, Polish Academy of
Sciences
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We are excited to have an online seminar by Prof. Gabrielle Girardeau from CRCN Inserm. Everyone is welcome to join the seminar!
Neural mechanisms for memory and emotional processing during sleep
The hippocampus and the amygdala are two structures required for emotional memory. While the hippocampus encodes the contextual part of the memory, the amygdala processes its emotional valence. During Non-REM sleep, the hippocampus displays high frequency oscillations called “ripples”. Our early work shows that the suppression of ripples during sleep impairs performance on a spatial task, underlying their crucial role in memory consolidation. We more recently showed that the joint amygdala-hippocampus activity linked to aversive learning is reinstated during the following Non-REM sleep epochs, specifically during ripples. This mechanism potentially sustains the consolidation of aversive associative memories during Non REM sleep. On the other hand, REM sleep is associated with regular 8 Hz theta oscillations, and is believed to play a role in the regulation of emotional reactions and the consolidation of emotional memories (emotional processing). Unraveling the fine neuronal dynamics related to REM sleep, Non-REM sleep and the transitions between states in the hippocampus-amygdala network will further our understanding of the implication of these sleep stages and related brain patterns in emotional processing.
You can join the seminar via ZOOM
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OIST - Osaka University: A Recipe for Scientific Synergy-Series 3 by Dr. Kazumasa Tanaka and Dr. Qingbo S. Wang
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Are you using environmental DNA (eDNA) in your research? Or are you just curious about eDNA and its potential applications? Please join us for this inter-unit meeting about eDNA research at OIST. Speakers from Ravasi, Husnik, N. Luscombe, Miller, and Satoh units will first briefly introduce their eDNA research projects and then we will have a roundtable discussion to share our expertise across units.
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Language: English
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Speaker: Dr. Yuko Harayama, Professor Emeritus, Tohoku University. Target audience: Everyone at OIST.
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Title:
Translational Supramolecular Chemistry
Abstract:
Supramolecular chemistry is about contacts between molecules. Translational supramolecular chemistry expects that offering new ways to get into contact on the molecular level will provide access to new structures and functions, which ultimately will allow us to tackle otherwise elusive challenges in science and society.
In this spirit, new interactions have been introduced to catalysis: Anion-π interactions in 2013, followed by chalcogen bonds in 2017 and pnictogen bonds in 2018. Several reactions and catalytic systems have been realized by now (foldamers, fullerenes, carbon nanotubes, artificial enzymes, electric fields, lipid bilayer membranes). Emergent properties include the breaking of the Baldwin rules and autocatalytic brevetoxin-like polyether cyclizations in π-acidic surfaces.
The same chalcogen bonds were the key to build mechanosensitive fluorescent probes that change color like lobsters during cooking. The resulting “fluorescent flippers” are the first small-molecule probes that can image physical forces in living cells. Mechanobiological changes in membrane tension can now be imaged throughout, from mitochondrial fission, endocytosis, secretory pathway, nuclear envelope to morphogenesis in early mammalian embryos. Addressing a current need in the life sciences, they had to be commercialized to assure distribution. Flipper probes are thus as an example for the direct translation of demanding supramolecular chemistry principles into products that do well on the market.
The third example for the spirit of translational supramolecular chemistry focuses on dynamic covalent exchange cascades to find new ways to enter into cells. The resulting thiol-mediated uptake emerges as complex network that encodes for cell penetration in the broadest sense, working from genome editing in live animals to general cytosolic delivery into deep tissue, explaining the mystery of FDA-approved antisense oligonucleotide phosphorothioates, affording inhibitors for the cellular entry of pathogens, including SARS-CoV-2 – but how does it really work?
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Andrew Mathas, University of Sydney
Title: Content systems and KLR algebras
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[Neuroscience Club] Dr. Terufumi Fujiwara, Postdoctoral Fellow, Champalimaud Foundation, Portugal. Language: English.
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Target audience: Interns, Students, PostDocs, and those who are interested in the same research field.
Language: English