Past Events

[Seminar] "Rejuvenated MSC-derived extracellular vesicles from aged donors show enhanced potency in macrophage immunomodulation and wound healing" by Prof. Tomas Skutella

2026-10-23
Center building C209
Speaker: Prof. Dr. Thomas Skutella
 
Talk Title: Rejuvenated MSC-derived extracellular vesicles from aged donors show enhanced potency in macrophage immunomodulation and wound healing
 
Affiliation: Head of the Department of Neuroanatomy in the Institute for Anatomy and Cell Biology, Heidelberg University, Germany.
 
Abstract: 
Mesenchymal stromal cells (MSCs) from aging donors lose regenerative and immunomodulatory potency, and there are no validated measures to distinguish rejuvenated from residual senescence. We reprogrammed bone-marrow MSCs from four adult donors to induced pluripotent stem cells and re-differentiated them under two conditions. iMSCs clustered with MSCs, showed promoter methylation inversely coupled to gene expression, retained residual senescence and desmosome signatures, and their EVs suppressed LPS-induced IL-6 and TNF-α, outperforming EVs from aged MSCs and hiPSCs. iMSC-EVs also promoted endothelial wound closure and gained a distinct protein- and small-RNA cargo signature, including NF-κB-targeting miRNAs and reproducibly reduced piRNAs. The same potency and rejuvenation framework was assessed in vivo in a diabetic wound model. These quality and potency metrics may support release testing and mechanism-guided product development of rejuvenated MSC-derived therapeutics.
 

 

[Seminar] "Molecular functions of the nuclear lamina in cell aging & senescence" by Dr. Oliver Dreesen

2026-02-12
Center building C210

Speaker: Dr.  Oliver Dreesen, Senior Principal Investigator, Cell Aging Laboratory,  A*STAR Skin Research Laboratories (A*SRL)

Talk Title:  Molecular functions of the nuclear lamina in cell aging & senescence

 

[Seminar for the OIST Community] Prof. Naoko Ohtani & Prof. Akiko Takahashi on Senescence and Cancer

2026-01-23
Auditorium

Join us for a special seminar at OIST, part of the A3 Foresight Meeting, presented by Prof. Ohtani and Prof. Takahashi.

Prof. Naoko Ohtani, Osaka Metropolitan University

Prof. Akiko Takahashi, Japanese Foundation for Cancer Research

[Seminar] "TORC1-containing signaling endosomes: Discovery and characterization of a cellular signaling centre" by Dr. Riko Hatakeyama

2025-12-08
Center building C210

Speaker: Dr. Riko Hatakeyama, University of Aberdeen, Scotland, UK

Title: TORC1-containing signaling endosomes: Discovery and characterization of a cellular signaling centre.

 

[Seminar] "NcRNA in neural development, degeneration, and aging" by Dr. Jun-An Chen

2025-03-10
Lab3, C700

[Affiliation]  Research Fellow: Principal Investigator, Institute of Molecular Biology, Academia Sinica, Taiwan.

[Seminar Title] NcRNA in neural development, degeneration, and aging
 

[Seminar] "Dissecting the senescence regulatory network" by Dr. Chanhee Kang

2025-02-17
Lab3, C700

[Affiliation] Associate Professor, SSTF Investigator, SUHF Young Investigator
School of Biological Sciences, Seoul National University

[Seminar Title] Dissecting the senescence regulatory network 

 

 

[Seminar] Dr. Junichi Ikenouchi "How are tight junctions different from other cell adhesion structures?"

2024-03-01
Seminar Room L5D23

Dr. Junichi Ikenouchi

Department of Biology, Faculty of Sciences, Kyushu University

[Seminar] Dr. Misato Ohtani "Active mRNA metabolism is a key for the plastic regulation of cell potency in plants

2022-07-05
Lab3 C700

Membranology Unit (Kono Unit) would like to invite you to the seminar by Dr. Misato Ohtani.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo

Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology

RIKEN, Center for Sustainable Resource Sciences

 

[Seminar] Dr. Takaomi Sanda "Lineage- and stage-specific oncogenicity of master transcription factors in cancers"

2022-07-04
Lab3 C700

Membranology Unit (Kono Unit) would like to invite you to the seminar by Dr. Takaomi Sanda.

Associate Director and Principal Investigator in Cancer Science Institute of Singapore; Associate Professor in Department of Medicine, National University of Singapore