Membranology Unit (Keiko Kono)
Cellular wounding and repair of local plasma membranes occur constantly in our bodies. Plasma membrane damage can be induced by various triggers ranging from physical disruption and pathogen invasion to physiological cellular activities, such as muscle contraction. Accumulating evidence suggests the involvement of cellular wound healing in various diseases, including Duchenne muscular dystrophy. However, the molecular mechanisms and physiological consequences of plasma membrane repair are poorly understood. Our unit tackles these issues using cell biology, biochemistry and genetics in multiple systems, including yeast and human cultured cells. We previously discovered two key mechanisms: 1) proteasomal degradation triggers repair responses (Kono et al., Cell, 2012), and 2) a cell cycle checkpoint in G1 monitors plasma membrane damage (Kono et al., PNAS, 2016). A long-term scientific goal will be to reveal the link between cancer/senescence and a plasma membrane.
Today is Allyson's last day. She showed her talent not only as an experimentalist but as an illustrator! She made pretty bookmarks for us. Thank you Allyson, we will follow up your beautiful results to finish up a paper. Best of the luck with your Ph.D. life!
We went out to have a welcome lunch for intern student Allyson and postdoc Shinju. It was all you can eat sushi. Fantastic!
Dr. Yohsuke Moriyama is awarded the Kakenhi grant, Grant-in-Aid for Challenging Research (Exploratory). Congrats Yohsuke!