Membranology Unit (Keiko Kono)

Cellular wounding and repair of local plasma membranes occur constantly in our bodies. Plasma membrane damage can be induced by various triggers ranging from physical disruption and pathogen invasion to physiological cellular activities, such as muscle contraction. Accumulating evidence suggests the involvement of cellular wound healing in various diseases, including Duchenne muscular dystrophy. However, the molecular mechanisms and physiological consequences of plasma membrane repair are poorly understood. Our unit tackles these issues using cell biology, biochemistry and genetics in multiple systems, including yeast and human cultured cells. We previously discovered two key mechanisms: 1) proteasomal degradation triggers repair responses (Kono et al., Cell, 2012), and 2) a cell cycle checkpoint in G1 monitors plasma membrane damage (Kono et al., PNAS, 2016). A long-term scientific goal will be to reveal the link between cancer/senescence and a plasma membrane.

 

 

Latest Posts

  • 12/25/2019, Munissa, Jan and Masato Farewell Lunch

    Lab lunch at the Orange, Kafuu hotel, to say good-bye to the rotation students. Munissa, Jan and Masato, you guys were exceptionally productive! We really enjoyed working with you. Thank you!!

     

     

  • 10/18/2019, Munissa, Jan and Masato Welcome Lunch

    We went out to have welcome lunch at Moon beach hotel. This term, we host three talented and highly motivated rotation students, Munissa, Jan and Masato. The lab is full of energy!

  • 8/8/2019, Allyson Intern Last Day

    Today is Allyson's last day. She showed her talent not only as an experimentalist but as an illustrator! She made pretty bookmarks for us. Thank you Allyson, we will follow up your beautiful results to finish up a paper. Best of the luck with your Ph.D. life!