Neural coordination in (mal)adaptive memory (ONOS)

 

Memories shape everyday behaviour, typically informing effective responses but sometimes driving maladaptive ones. This process engages complex patterns of neuronal activity distributed across brain networks, including the hippocampus. What features of neural activity underlie memory-guided behaviour? By considering spatio-temporally organised neuronal spiking and rhythmic fluctuations of the local field potentials, I will discuss in this talk recent findings that describe population-level patterns supporting internal processing of mnemonic information. I will show how leveraging these findings allow implementing cell type-selective and network pattern-informed interventions to draw causal involvement of neural dynamics at the nexus of brain and behaviour, and prevent the expression of unwanted memories. Altogether, these data will highlight how fine-grained neural dynamics distributed across the hippocampus and partner circuits promote memory-guided behaviour, for better or worse.