Vincent Laudet

Vincent Laudet
Vincent Laudet
Professor (Adjunct)
‘Habilitation’ to direct research, University of Lille I, France, 1996
Ph.D. in Life and Health Sciences, University of Lille I, France, 1992
Research performed at the Institut Pasteur de Lille, Molecular Oncology lab
Mentor: Dominique Stéhelin
Title: Structure and evolution of nuclear hormone receptors
vincent.laudet
France

Short Bio

Vincent Laudet has performed the first evolutionary analysis of the nuclear hormone receptor (NR) superfamily focusing on: (i) the study of retinoids and thyroid hormone receptors in the evolutionary process through Evo/Devo studies using amphioxus as a model organisms; (ii) the study of the evolution of ligand-binding abilities of various NRs and the origin of NR ligands; (iii) the effects of environmental pollutants such as bisphenol A or chlorpyrifos acting via nuclear receptors.

Since 2014 he developed coral reef fish as a marine model organism for Eco/Evo/Devo studies. His group focuses on the evolution of life history strategies, in particular the recruitment of fish larvae to the reef and the role that hormones played in that process.

Vincent Laudet was successively Professor at the Ecole Normale Supérieure de Lyon in France from 1997 to 2015 where he was the director of the Institut de Génomique Fonctionnelle de Lyon (IGFL) and then Director of the Observatoire Océanologique de Banyuls-sur-Mer.

Vincent Laudet’s laboratory has contributed to more than 220 scientific papers and 40 reviews (h-index: 74) including two books in molecular endocrinology, molecular evolution, genomics and developmental biology.

Professional Experience

  • Professor Exceptional Class at Sorbonne Université. Director of the Oceanologic Observatory of Banyuls-sur-Mer and Group Leader of the team "Eco/Evo/Devo" at the BIOM unit, 2015-2019
  • Professor Exceptional Class at the Ecole Normale Supérieure de Lyon. Director of the IGFL and Group Leader of the team “Molecular Zoology” at the IGFL, 2007-2015
  • Professor at the Ecole Normale Supérieure de Lyon and Group Leader of the team “Structure and Evolution of Nuclear Hormone Receptors ” in the Laboratory of Molecular and Cellular Biology, 1997-2007
  • CNRS Staff Scientist at the Institut Pasteur de Lille, Molecular Oncology lab, 1994-1997

Awards

  • Faculty of 1000 -, Marletaz et al., Nature 2018
  • Senior Member of the Institut Universitaire de France 2010 – 2015
  • Faculty of 1000 Abad et al., Nature Biotech 2008
  • Faculty of 1000 Paris et al., Current Biol. 2008
  • Faculty of 1000 Schubert et al., Dev. Biol. 2006    
  • Finalist of the EU Descartes Prize in the project Pathfinder coordinated by Pr. Jan-Ake Gustafsson 2005    
  • Faculty of 1000 Jaillon et al., Nature 2004
  • Junior Member of the Institut Universitaire de France 2000 - 2005

Select Publications

  • Roux N, Lami R, Salis P, Magré, K, Romans P, Masanet P, Lecchini D and Laudet V. Sea anemone and clownfish microbiota diversity and variation at the initial steps of the symbiosis. Scientific Reports. 2019, 9: 19491.
  • Roux N, Salis P, Lambert A, Logeux V, Soulat O, Frederich B, Lecchini D and Laudet V. Staging and normal table of post-embryonic development of the clownfish (Amphiprion ocellaris). Developmental Dynamics, 2019, 248: 545-568.
  • Gibert Y, Samarut E, Ellis MK, Jackman WR and Laudet V. The first formed tooth serves as a signalling center to induce the formation of the dental row in zebrafish. Proceedings of the Royal Society B. 2019, 286: 20190401.
  • Salis P, Lorin T, Laudet V, Frédérich B. Magic Traits in Magic Fish: Understanding Color Pattern Evolution Using Reef Fish. Trends in Genetics. 2019, 35: 265-278
  • Salis P, Roux N, Soulat O, Lecchini D, Laudet V. Frederich B. (2018) Ontogenetic and phylogenetic simplification during white stripe evolution in clownfishes. BMC Biology, 16(1): 90.
  • Handberg-Thorsager M*, Gutierrez-Mazariegos J*, Nadendla EK, Bertucci P, Arold ST, Tomançak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V*, Arendt D*, Schubert M*. (2018) The ancestral retinoic acid receptor (RAR) was a low-affinity sensor triggering neuronal differentiation, Science Advances, 4: eaao1261. . (* equal first/last authors).
  • Holzer G, Besson M, Lambert A, François L, Barth P, Gillet B, Hughes S, Piganeau G, Leulier F, Viriot L, Lecchini D Laudet V. (2017) Larval fish recruitment to reefs is a thyroid hormone-mediated metamorphosis sensitive to the pesticide chlorpyrifos. eLife, 30;6. pii: e27595.
  • Markov GV, Gutierrez-Mazariegos J, Pitrat D, Billas IM, Bonneton F, Moras D, Hasserodt J, Lecointre G, Laudet V. (2017) Origin of an ancient Hormone/Receptor couple revealed by resurrection of an ancestral Estrogen Science Advances, 3: e1601778.