Principle Investigator

Matthias Wolf
matthias dot wolf at

Career History and Education

Associate Professor, Okinawa Institute of Science and Technology
Assistant Professor, Okinawa Institute of Science and Technology
Post-doctoral Scholar, Harvard Medical School
PhD Biophysics, Brandeis University
Mag.Pharmacy, University of Innsbruck, Austria


Current Members


Hideyuki Matsunami - Staff Scientist
hideyuki dot matsunami at

Hideyuki has worked on structural studies of macromolecular assemblies such as bacterial flagellum or metabolic enzymes by X-ray crystallography since he started his academic career at Osaka University, where he received his PhD degree in Biochemistry. Hideyuki become a member of the Wolf unit in 2018 after a stint at RIKEN. Hideyuki is interested in understanding of molecular mechanisms underlying protein DNA/RNA complexes or membrane proteins by Cryo-EM.

Tae Gyun Kim - Staff Scientist
taegyun dot kim at

As part of Tae Gyun's Ph.D. studies on structural biology at the Pohang University of Science and Technology in South Korea, he receive an in-depth education based on X-ray crystallography. After a post-doc in the US and South Korea, Tae Gyun joined the Wolf Unit at the OIST as a staff scientist, where he continued his research to investigate the molecular assemblies of mitochondrial calcium channel complex using cryo-electron microscopy. Out of the lab, he is a father with a broad mind and a devoted husband.

Jaekyung Hyun - Staff Scientist
jaekyung dot hyun at

Jaekyung worked on the structures and assembly mechanisms of virus capsid proteins through his MSc and PhD studies at University of Auckland, New Zealand. He then worked as a senior researcher at Korea Basic Science Institute, where he was involved in running the cryo-electron microscopy facility and helped various structural biology projects using cryo-EM single particle analysis. Jaekyung joined Wolf unit in January 2019. He is aiming to further refine his microscopy and image processing skills, and also looking forward to continue on structural analysis of virus capsids using cryo-EM.

Satoshi Shibata - Staff Scientist
satoshi dot shibata at

Satoshi has worked on a variety of projects involving supermolecule structure in bacteria, such as flagella, gliding machinery, and pili structure. After a long and productive week in the lab, you can sometimes find Satoshi fishing off one of the many fishing docks around Okinawa.

Melissa Matthews - Post-doctoral Scholar
melissa dot matthews at

Melissa began her career doing protein crystallography at the University of California-Davis, where she got her PhD studying enzymes involved in RNA editing and carbohydrate synthesis. Since joining the Wolf Lab in 2017, Melissa continues to study protein:RNA complexes, seeking to understand the mechanisms by which proteins discriminate between "target" and "non-target" RNA. When she's not in lab, Melissa enjoys traveling and loves spending time outdoors.

Nadishka Jayawardena - Post-doctoral Scholar
gimshan dot jayawardena at

Nadishka has mainly worked on cancer therapeutics during his postgraduate studies in New Zealand. He obtained his PhD from University of Otago (New Zealand) in 2020, where his research was focused on understanding the architecture and receptor interactions of an oncolytic virus, Seneca Valley virus (SVV) using cryo-EM. At present, Nadishka is interested in understanding the molecular architecture of viruses ranging from bacteriophage to nucleocytoplasmic large DNA viruses, while still continuing his work on SVV. In his leisure time, he loves to capture photographs of wildlife and scenic landscapes.

Makoto Schreiber - Graduate Student
makoto dot schreiber at

Makoto joined the Wolf Lab in 2015 to work towards his Ph.D. He enjoys using methods developed for biological TEM in materials science problems and vice-versa. His main focus is on the development of techniques for the characterization of amorphous materials. He has also been working on several Cryo-EM techniques and the investigation of charging processes occurring during image acquisition.

Rika Yoshizawa - Research Unit Administrator
rika dot yoshizawa at

Although Rika originally came to Okinawa as a human resource professional for an international hotel, life is full of magic, and in September 2012 she joined the new and interesting world of OIST as a research unit administrator. Rika loves chocolate, champagne brunch and, most of all, 3-year old Halo, her sometimes stubborn but loyal miniature dachshund, known to be the cutest in the world!

Former Lab Members


Yoshimasa Takizawa - Staff Scientist
2018: Assistant Professor at Tokyo University


Yukihiko Sugita - Post-doctoral Scholar
2018: Institute for Protein Research, Osaka University

Alan Maigné - Staff Scientist
2017: Senior Science Manager at the Quantum Matter Electron Microscopy Center at the University of British Columbia

Jacob Shun-Jen Yang - Staff Scientist
2015: Group Leader at Development Center for Biotechnology, Taipei

Vladimir Meshcheryakov - Staff Scientist
2015: Staff Scientist with Prof. Vivien Wang, University of Macau