Science Talk by Prof. Svante Pääbo, 2022 Nobel Prize in Physiology or Medicine

Science Talk by Prof. Svante Pääbo, 2022 Nobel Prize in Physiology or Medicine

Speaker: Prof. Joshua Shaevitz, Princeton University

Language: English (no interpretation). Target audience: General audience / everyone at OIST and beyond. Freely accessible to all OIST members and guests without registration (also via Zoom).

Language: English (no interpretation). Target audience: General audience / everyone at OIST and beyond. Freely accessible to all OIST members and guests without registration (also via Zoom).

Dr. Mog Stapleton, East China Normal University. Language: English (no interpretation). Target audience: General audience / everyone at OIST and beyond. Freely accessible to all OIST members and guests without registration (also via Zoom).

Dr. Mark Wildon, University of London. Language: English (no interpretation). Target audience: General audience / everyone at OIST and beyond. Freely accessible to all OIST members and guests without registration (also via Zoom).

Online Lecture series "The quest for mathematical understanding of artificial intelligence" by Professor Sanjeev Arora, Computer Science at Princeton University.

Dr. Kyoji Saito, University of Tokyo / Kyoto University. Language: English (no interpretation). Target audience: General audience / everyone at OIST and beyond. Freely accessible to all OIST members and guests without registration (also via Zoom).

Title: Dynamic Nature of Memory Representation and the Hippocampal Network

Abstract:

Memories are encoded through long-lasting changes in the network of the brain. These memory traces can interfere with each other and therefore lead to instability of the representations. Indeed, a previous study discovered that instability is preferentially embedded within spatial maps in memory engram cells in the hippocampus even though their activity is still functionally linked to memory-relevant behaviors (Tanaka et al., 2018). Notably, higher instability of place cells is often observed in aberrant network states caused by various factors, including aging, stress, or epileptic seizure, which cause memory impairments (e.g., Yan et al., 2003; Kim et al., 2007; Karnam et al., 2009). These studies highlight two distinct types of instability leading to the opposite outcomes of hippocampal memory. In my talk, I will introduce our unpublished studies aiming at 1) elucidation of neuronal underpinning that survives extreme plasticity yet supports memory and 2) development of a novel approach to reset the aberrant network state. These studies will provide fundamental insight into physiological and pathological instability in the neuronal network.

This seminar is open to the OIST community. Visit https://groups.oist.jp/faculty-lunch

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