"Screening of phosphorylation dependent protein-protein interaction inhibitors"

Dear all,

Cell Signal Unit (Yamamoto Unit) would like to invite you to a seminar by Dr. Nobumoto WATANABE.

Speaker: Dr. Nobumoto WATANABE.

Unit leader, Bio-Active Compounds Discovery Research Unit, RIKEN CSRS, Wako, Saitama, 351-0198

Title: Screening of phosphorylation dependent protein-protein interaction inhibitors

Abstract: Protein phosphorylation is a key event in signal transduction pathways. When upstream signals are stimulated, protein kinases are activated and phosphorylate their substrates, modulating their localization, conformation, and activity. In some cases, phosphorylated substrates become recognizable to other proteins; such interactions transduce and propel the signal onward. Certain domains specifically recognize phosphorylated residues of proteins, regulating cell growth and differentiation. Because the proteins that contain these domains also mediate diseases that are caused by deregulated signal transduction, small molecules that inhibit such motifs are attractive candidates for the treatment of diseases, such as cancer. In this seminar, we summarize the domains that recognize phosphorylated proteins, particularly serine, threonine-phosphorylated sequences in target proteins. In addition, we introduce a high-throughput screen that we developed to identify small-molecule inhibitors of phosphorylation-dependent protein-protein interactions. Several examples of small molecule, which inhibit the cell cycle progression, will be presented, and the potential uses of this system are discussed.

Host:

Tadashi Yamamoto, Cell Signal Unit

We look forward to seeing many of you there.