Identification of small molecule inhibitors of stromal fibroblast cell migration accelerated by cancer cells

Dear All,

Cell Signal Unit (Yamamoto Unit) would like to inform you of a seminar by Dr. Nobumoto Watanabe from RIKEN Center for Sustainable Resource Science.

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Date: Wednesday, March 7, 2018

Time: 14:00-15:00

Venue: C016, Level C, Lab 1

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Speaker:

Dr. Nobumoto Watanabe, RIKEN Center for Sustainable Resource Science

Title:
Identification of small molecule inhibitors of stromal fibroblast cell migration accelerated by cancer cells

Abstract:
Stromal fibroblasts, which occupy a major portion of the tumor microenvironment, play an important role in cancer metastasis. Thus, targeting of these fibroblasts activated by cancer cells (carcinoma associated fibroblasts; CAFs) might aid in the improved treatment of cancer metastasis. NIH3T3 fibroblasts co-cultured with MCF7 cells displayed enhanced migration compared to NIH3T3 fibroblasts cultured alone. We used this system to identify the small molecule inhibitors responsible for their enhanced migration, a characteristic of CAFs using chemical biology technique. Some example of identified inhibitors and their mechanism of action will be presented.

Host:
Prof. Tadashi Yamamoto

We hope to see many of you at the seminar.

Best regards,

Yuki Nakagawa

Research Unit Administrator

Cell Signal Unit