A hepatic post-transcriptional control of whole body metabolic homeostasis through FGF21 regulation by CCR4-NOT deadenylase

Dear All,

Cell Signal Unit (Yamamoto Unit) would like to inform you of a seminar by Dr. Sakie Katsumura from the University of Texas.

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Date: Wednesday, December 11, 2019

Time: 16:00-17:00

Venue: D015, Level C, Lab 1

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Speaker:

Dr. Sakie Katsumura from the University of Texas

Title:
A hepatic post-transcriptional control of whole body metabolic homeostasis through FGF21 regulation by CCR4-NOT deadenylase

Abstract:
Whole-body metabolic homeostasis is tightly controlled by hormone-like proteins, which are derived from non-endocrine organs, including adipose tissue and liver, with systemic or paracrine effects. Fibroblast growth factor 21 (FGF21) is a hormone-like protein, which is emerging as a major regulator of whole-body metabolism and has therapeutic potential for treating metabolic syndrome. Here, we uncovered that Fgf21 is a target mRNA of the CCR4-NOT deadenylase complex that controls mRNA expression encoding metabolic factors by destabilizing mRNAs. The disruption of CCR4-NOT deadenylase activity in the liver, by targeting its catalytic subunit CNOT6L, leads to an increase in FGF21 levels and improves metabolic disorders, such as obesity and insulin resistance. Overall, our findings describe a new paradigm in regulation of whole body metabolism whereby a post-transcriptional network in the liver governs systemic metabolic homeostasis via FGF21.

Host:
Prof. Tadashi Yamamoto

We hope to see many of you at the seminar.

Best regards,

Yuki Nakagawa

Research Unit Administrator

Cell Signal Unit