FY2017 Annual Report

Full Unit Name
Assistant Associate Professor First Last

Abstract

Hydrogels are soft materials with distinct three-dimensional (3D) networks capturing large water content. The similarity of hydrogels to natural tissue has made them the most promising biomaterials for use in human bodies. During the past several decades, hydrogels have attracted considerable attention from scientists in different research fields. With their contributions, the research in this field has experienced significant advances both in content and in style. Organometallic hydrogels, one special category of hydrogels in which metal ions participate in the 3D network, have become one of the pioneering types of soft materials. Endowed with the unique properties of metal ions and coordination chemistry’s structural diversity, this type of material has shown great potential for intelligent materials as part of a smart future.

1. Staff

  • Dr. Guanying Li, Postdoctoral Fellow
  • Dr. Enming Du, Postdoctoral Fellow
  • Dr. Yunhui Zheng, Postdoctoral Fellow
  • Dr. Weiji, Postdoctoral Fellow
  • Dr. Dingze Mang, Postdoctoral Fellow
  • Sona Roy, Graduate Student
  • Shijin Zhang, Graduate Student
  • Xunwu Hu, Rotation Student
  • Sachie Yukawa, Rotation Student
  • Swathie, Rotation Student
  • Xia Wu, Intern Student
  • Hitomi Shinzato, Administrative Assistant

2. Collaborations

2.1 The Title or Name or Topic of the Collaboration

  • Description: Details and description of the collaboration, if necessary.
  • Type of collaboration: Joint research
  • Researchers:
    • Professor First Last, Some University
    • Dr. First Last, Another University

2.2 The Title or Name or Topic of the Collaboration

  • Description: Details and description of the collaboration, if necessary.
  • Type of collaboration: Joint research
  • Researchers:
    • Professor First Last, Some University
    • Dr. First Last, Another University

3. Activities and Findings

3.1 Subsection Title If Necessary

The extracellular matrix (ECM) is the natural fibrous scaffold that regulates cell behavior in a hierarchical manner. By mimicking the dynamic and reciprocal interactions between ECM and cells, higher‐order molecular self‐assembly (SA), mediated through the dynamic growth of scaffold‐like nanostructures assembled by different molecular components, was developed. Designed and synthesized were two self‐sorted coumarin‐based gelators, a peptide molecule and a benzoate molecule, which self‐assemble into nanofibers and nanobelts, respectively, with different dynamic profiles. Upon the dynamic growth of the fibrous scaffold assembled from peptide gelators, nanobelts assembled from benzoate gelators transform into a layer‐by‐layer nanosheet, reaching ninefold increase in height. By using light and an enzyme, the spatial–temporal growth of the scaffold can be modified, leading to in situ height regulation of the higher‐order architecture.

Figure 1: A) SEM and B) TEM images of SA of 1 in H2O/DMSO (v/v=9:1) at concentration of 0.8 wt %. C) SEM and D) TEM images of SA of 2 in H2O/DMSO (v/v=9:1) at concentration of 0.8 wt %. E)–G) CD spectra of E) 1 (0.05 wt %), F) 2 (0.05 wt %), and G) a 1/2 mixture ([1]=0.05 wt %, [2]=0.05 wt %) in H2O/DMSO (v/v=9:1). Exp. and Theor. represent experimental and theoretical CD spectra, respectively. H) CD spectra of a 1/2 mixture at various ratios in H2O/DMSO (v/v=9:1). I) Plots of CD intensities of the 1/2 mixture at 231 nm and 255 nm versus mixing ratios from H. Theoretical lines were calculated from the CD intensities of each component at various concentrations. Data represent mean±standard deviation of the mean (n=3).

Figure 2: SEM images and the correlated AFM images with height profiles of A) SCSA of 1and B)–F) a mixture of 1 (8 mg mL−1) with 2 at various concentrations, from B) 2 mg mL−1, C) 4 mg mL−1, D) 8 mg mL−1, E) 16 mg mL−1, to F) 32 mg mL−1 in H2O/DMSO (v/v=9:1). The inset SEM image in (D) is the section structure of layer‐by‐layer nanosheet.

The third image, Figure 3, is a single image with the caption below it.

Figure 3Illustration of higher‐order organization through the synergy of two types of self‐sorted assembly with molecular structures of gelators 1 and 2.

4. Publications

4.1 Journals

  1. Enming Du, Xunwu Hu, Sona Roy, Peng Wang, Kieran Deasy, Toshiaki Mochizuki and Ye Zhang.* "Taurine-Modified Ru(II)-Complex Targets Cancerous Brain Cells for Photodynamic Therapy" Chem. Commun. 2017, 53, 6033-6036
  2. Wei Ji, Shijin Zhang, Sachie Yukawa, Shogo Onomura, Toshio Sasaki, Kun'ichi Miyazawa, and Ye Zhang.* "Regulate  Higher-order Organization through the Synergy of Two Self-sorted Assemblies" Angew. Chem. Int. Ed. 2018, 57, 3636-3640

4.2 Books and other one-time publications

Nothing to report

4.3 Oral and Poster Presentations

([NOTE] *Seminars and workshops by OIST faculty/unit members (either with or without other speakers), either at OIST or at other institutions than OIST, should be included in the 4.3 Oral and Poster Presentations.

  1. Efghijk, S., Uxyaabc, E., Defgh, K., Cdefg, HI. Article Title Here as It Appears in the Publication. Poster or Presentation Title in Italics, Event 2010, City Name, Country, FromDate-ToDate (2011).
  2. Efghijk, S., Uxyaabc, E., Defgh, K., Cdefg, HI. Article Title Here as It Appears in the Publication. Poster or Presentation Title in Italics, Event 2010, City Name, Country, FromDate-ToDate (2011).

5. Intellectual Property Rights and Other Specific Achievements

Nothing to report

6. Meetings and Events

6.1 Design and Functionalization of Supramolecular Assemblies, Liquid Crystals, and Macromolecules

  • Date: June 06, 2017
  • Venue: OIST Campus Centre Building C209
  • Speaker: Prof. Takashi Kato (Tokyo University)

6.2 Triplet Energy Migration and Photon Upconversion in Molecular Self-Assemblies

  • July 03, 2017
  • Venue: OIST Campus Lab3 C700
  • Speaker: Prof. Nobuo Kimizuka (Kyushu University)

Nothing to report.