物理生物学ユニット（ジョナサン・ミラー）

研究概要

物理生物学ユニットでは、主に生物系の研究を対象とした物理科学ベースのツールを開発しています。ゲノム進化および集団ゲノム科学などを主な対象とし、遺伝的変異が自然選択と進化とを結合する仕組みに関する新たな知見を得ようとしています。

参考

  1. B. Kammandel et al. (1999). Developmental Biology 205, 79–97.
  2. G. Bejerano et al. (2004). Science 304(5675), 1321-5.
  3. J. Miller and P. Havlak (2005). CSHL Genome Informatics Meeting.  
  4. The author is deeply grateful to Sydney Brenner for asserting the application of the term “linkage” to these observations.
  5. W. Salerno et al. (2006). Proc Natl Acad Sci USA, 103(35), 13121-5.
  6. J. Miller (2007). Genomic_Imprint_of_the_Interactome-_University_of_Genome_Evolution [PDF]
  7. J. Miller (2007). First annual q-bio conference on cellular information processing Santa Fe, NM (2007) [PDF]
  8. J. Miller (2009). IEICE technical report, Neurocomputing, 109(53) (20090518) [PDF]
  9. K. Gao, J. Miller (2011) Algebraic Distribution of Segmental Duplication Lengths in Whole-Genome Sequence Self-Alignments. PLoS ONE 6(7): e18464. doi:10.1371/journal.pone.001846 [PLoSone]
  10. M.V. Koroteev and J. Miller. Scale-free duplication dynamics: a model for ultraduplication. Phys. Rev. E. [PDF] (Supporting Materials )
  11. E.Taillefer, J.Miller. Algebraic length-distribution of sequence duplications in whole genomes. In Proc. of International conf. on natural computation, v. 3, p. 1454-1460, Shanghai, China, Jul. 2011. [PDF] (IEEE Explore)
  12. Eddy Taillefer and Jonathan Miller. Exhaustive computation of exact sequence duplications in whole genomes via super and local maximal repeats. In International Conference on Computer Engineering and Bioinformatics, Vol. 21, pp. 22–29, Cairo, Egypt, Oct. 2011. Excellent paper award. [PDF]